Basis: Trailing twelve months (TTM). Source: stored company filings and market data; unavailable inputs remain N/A.
Is the operating margin high or low?
The operating margin of -40.47% is 33% above its 5-year average of -60.79%, around the middle of its 5-year range (-136.95%–50.14%).
23.09% above its 12-month average of -52.62%.
Reported quarterly operating margin; no daily interpolation. Q2 FY2026 (2026-06-30): -38.18%.
OPERATING MARGIN
-40.47%
OPERATING MARGIN AVG TTM
-52.62%
OPERATING MARGIN AVG 3Y
-64.48%
OPERATING MARGIN AVG 5Y
-60.79%
OPERATING MARGIN AVG 10Y
-36.47%
OPERATING MARGIN AVG 15Y
-46.46%
OPERATING MARGIN AVG 20Y
-43.54%
CURRENT VS TTM AVG
+23.09%
CURRENT VS 3Y AVG
+37.24%
CURRENT VS 5Y AVG
+33.42%
CURRENT VS 10Y AVG
-10.97%
CURRENT VS 15Y AVG
+12.89%
CURRENT VS 20Y AVG
+7.04%
SECTOR MEDIAN · HEALTHCARE
0.00%
median of 551 covered companies
CURRENT VS SECTOR MEDIAN
N/A
vs the sector median at left
Ionis Pharmaceuticals, Inc.
Market Cap
$7.30B
Operating Margin
-40.47%
TTM Avg
-52.62%
3Y Avg
-64.48%
5Y Avg
-60.79%
Market Cap
$6.74B
Operating Margin
-362.95%
TTM Avg
-1052.99%
3Y Avg
-3382.94%
5Y Avg
-3698.56%
Market Cap
$7.63B
Operating Margin
25.61%
TTM Avg
21.87%
3Y Avg
15.23%
5Y Avg
12.87%
Market Cap
$7.62B
Operating Margin
-92.94%
TTM Avg
-50.55%
3Y Avg
-48.57%
5Y Avg
-48.57%
Market Cap
$7.66B
Operating Margin
-695.44%
TTM Avg
-1799.08%
3Y Avg
-2632.66%
5Y Avg
-1827.24%
Market Cap
$6.68B
Operating Margin
13.46%
TTM Avg
14.22%
3Y Avg
14.89%
5Y Avg
15.72%
Market Cap
$6.55B
Operating Margin
4.50%
TTM Avg
4.35%
3Y Avg
-1.93%
5Y Avg
-10.04%
| NAME | MARKET CAP | OPERATING MARGIN | TTM | 3Y | 5Y |
|---|---|---|---|---|---|
| Ionis Pharmaceuticals, Inc. (IONS) | $7.30B | -40.47% | -52.62% | -64.48% | -60.79% |
| Alkermes plc (ALKS)vs › | $7.04B | 17.21% | 22.11% | 17.14% | 11.01% |
| GRAIL Inc. (GRAL)vs › | $6.74B | -362.95% | -1052.99% | -3382.94% | -3698.56% |
| HealthEquity, Inc. (HQY)vs › | $7.63B | 25.61% | 21.87% | 15.23% | 12.87% |
| Hinge Health, Inc. (HNGE)vs › | $7.62B | -92.94% | -50.55% | -48.57% | -48.57% |
| Cytokinetics, Incorporated (CYTK)vs › | $7.66B | -695.44% | -1799.08% | -2632.66% | -1827.24% |
| Immunovant, Inc. (IMVT)vs › | $6.75B | 0.00% | 0.00% | 0.00% | 0.00% |
| Chemed Corporation (CHE)vs › | $6.68B | 13.46% | 14.22% | 14.89% | 15.72% |
| Hims & Hers Health, Inc. (HIMS)vs › | $6.55B | 4.50% | 4.35% | -1.93% | -10.04% |
| Lantheus Holdings, Inc. (LNTH)vs › | $6.53B | 19.43% | 24.98% | 20.49% | 11.07% |
Gross Margin
98.2%
Operating Margin
-40.5%
Operating Margin = Operating Income / Revenue
Operating margin is the percentage of revenue remaining after operating expenses, reflecting operating efficiency.
Expanded definitions: Investopedia, Wikipedia, Corporate Finance Institute
| DATE | OPERATING MARGIN |
|---|---|
| 2026-06-30 | -38.18% |
| 2026-03-31 | -47.72% |
| 2025-12-31 | -105.91% |
| 2025-09-30 | -102.21% |
| 2025-06-30 | 30.93% |
| 2025-03-31 | -111.59% |
| 2024-12-31 | -48.91% |
| 2024-09-30 | -111.09% |
| 2024-06-30 | -29.34% |
| 2024-03-31 | -125.12% |
| 2023-12-31 | -1.89% |
| 2023-09-30 | -99.35% |
| 2023-06-30 | -47.87% |
| 2023-03-31 | -87.45% |
| 2022-12-31 | -136.95% |
| 2022-09-30 | -37.03% |
| 2022-06-30 | -63.92% |
| 2022-03-31 | -40.52% |
| 2021-12-31 | 50.14% |
| 2021-09-30 | -64.50% |
| 2021-06-30 | -58.03% |
| 2021-03-31 | -82.41% |
| 2020-12-31 | -7.81% |
| 2020-09-30 | -22.82% |
| 2020-06-30 | -35.56% |
| 2020-03-31 | -45.83% |
| 2019-12-31 | 52.80% |
| 2019-09-30 | 1.50% |
| 2019-06-30 | -11.49% |
| 2019-03-31 | 40.89% |
| 2018-12-31 | 5.61% |
| 2018-09-30 | -12.77% |
| 2018-06-30 | -42.70% |
| 2018-03-31 | -2.29% |
| 2017-12-31 | -0.98% |
| 2017-09-30 | 9.56% |
| 2017-06-30 | 5.74% |
| 2017-03-31 | 16.83% |
| 2016-12-31 | 25.67% |
| 2016-09-30 | 14.52% |
| 2016-06-30 | -127.18% |
| 2016-03-31 | -148.21% |
| 2015-12-31 | -122.05% |
| 2015-09-30 | -98.00% |
| 2015-06-30 | 37.07% |
| 2015-03-31 | -14.91% |
| 2014-12-31 | 11.88% |
| 2014-09-30 | -48.78% |
| 2014-06-30 | -11.65% |
| 2014-03-31 | -105.35% |
| 2013-12-31 | -47.00% |
| 2013-09-30 | -108.14% |
| 2013-06-30 | -20.81% |
| 2013-03-31 | 3.75% |
| 2012-12-31 | -131.43% |
| 2012-09-30 | -241.76% |
| 2012-06-30 | 7.81% |
| 2012-03-31 | -79.43% |
| 2011-12-31 | -57.45% |
| 2011-09-30 | -107.74% |
| 2011-06-30 | -56.64% |
| 2011-03-31 | -76.17% |
| 2010-12-31 | -60.02% |
| 2010-09-30 | -31.26% |
| 2010-06-30 | -79.45% |
| 2010-03-31 | -16.31% |
| 2009-12-31 | -36.18% |
| 2009-09-30 | -38.83% |
| 2009-06-30 | -15.57% |
| 2009-03-31 | -2.03% |
| 2008-12-31 | 15.62% |
| 2008-09-30 | 0.60% |
| 2008-06-30 | 3.64% |
| 2008-03-31 | -33.96% |
| 2007-12-31 | -34.14% |
| 2007-09-30 | 26.03% |
| 2007-06-30 | -515.60% |
| 2007-03-31 | -853.10% |
| 2006-12-31 | -140.11% |
| 2006-09-30 | -561.45% |
| 2006-06-30 | -390.90% |
| 2006-03-31 | -323.03% |
| 2005-12-31 | -58.79% |
| 2005-09-30 | -162.83% |
| 2005-06-30 | -122.01% |
| 2005-03-31 | -315.87% |
| 2004-12-31 | -454.97% |
| 2004-09-30 | -246.12% |
| 2004-06-30 | -216.80% |
| 2004-03-31 | -181.54% |
| 2003-12-31 | -221.47% |
| 2003-09-30 | -168.82% |
| 2003-06-30 | -129.99% |
| 2003-03-31 | -135.28% |
| 2002-12-31 | -51.45% |
| 2002-09-30 | -86.25% |
