Which has grown faster, ALKS or IONS?

Over the past five years, ALKS grew revenue faster — ALKS at a 8.68% CAGR versus IONS at 4.91%.

Is ALKS or IONS more profitable?

ALKS runs the higher net margin — ALKS at 3.97% versus IONS at -64.64%.

How have ALKS and IONS total returns compared?

Over the past 10 years, ALKS delivered -0.82% and IONS delivered 1.80% annualized total return. Past performance doesn't predict future results.

Alkermes plc (ALKS) vs Ionis Pharmaceuticals, Inc. (IONS)

A side-by-side comparison of Alkermes plc and Ionis Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ALKS

Alkermes plc

$6.99B

$41.65HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

IONS

Ionis Pharmaceuticals, Inc.

$7.31B

$44.00HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — ALKS vs IONS

growth of $100 · dividends reinvested · last 10y

ALKS +1.1% (+0.1%/yr)IONS +50.0% (+4.1%/yr)IONS compounded faster over this window

ALKS IONS

ALKS vs IONS: by the numbers

•IONS is the larger company ($7.31B vs $6.99B market cap).
•ALKS is profitable (3.97% net margin) while IONS runs a net loss (-64.64%).
•ALKS grew revenue faster over the past five years (8.68% vs 4.91% CAGR).

Metrics side by side

Valuation

Metric	ALKS	IONS
P/E ratio	108.75	N/A
P/S ratio	4.19	8.37
P/B ratio	3.86	16.63
EV / EBITDA	44.98	2.21
FCF yield	3.17%	N/A

Profitability

Metric	ALKS	IONS
Gross margin	84.56%	98.16%
Operating margin	17.21%	-40.47%
Net margin	3.97%	-64.64%
ROE	3.66%	-128.44%
ROIC	2.12%	-20.37%

Growth (annualized)

Metric	ALKS	IONS
Revenue CAGR (5Y)	8.68%	4.91%
FCF CAGR (5Y)	20.00%	N/A
Total return CAGR (5Y)	6.73%	5.82%

Frequently asked

Which has grown faster, ALKS or IONS?: Over the past five years, ALKS grew revenue faster — ALKS at a 8.68% CAGR versus IONS at 4.91%.
Is ALKS or IONS more profitable?: ALKS runs the higher net margin — ALKS at 3.97% versus IONS at -64.64%.
How have ALKS and IONS total returns compared?: Over the past 10 years, ALKS delivered -0.82% and IONS delivered 1.80% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ALKS analysis Full IONS analysis Interactive comparison tool

Dig into the metrics

Alkermes P/E ratio Alkermes ROE Ionis Pharmaceuticals ROE Alkermes operating margin Ionis Pharmaceuticals operating margin Alkermes revenue growth Ionis Pharmaceuticals revenue growth Alkermes free cash flow Ionis Pharmaceuticals free cash flow

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.