Ionis Pharmaceuticals, Inc. (IONS) vs Lantheus Holdings, Inc. (LNTH)
A side-by-side comparison of Ionis Pharmaceuticals, Inc. and Lantheus Holdings, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
IONS
Ionis Pharmaceuticals, Inc.
$44.10HealthcareDelayed quote: Oct 6, 2026, 12:25 PM EDT
LNTH
Lantheus Holdings, Inc.
$99.95HealthcareDelayed quote: Oct 6, 2026, 12:25 PM EDT
Total return — IONS vs LNTH
growth of $100 · dividends reinvested · last 10yIONS +22.0% (+2.0%/yr)LNTH +1121.8% (+28.4%/yr)LNTH compounded faster over this window
Log scale — wide-divergence pair
IONS LNTH
IONS vs LNTH: by the numbers
- •IONS is the larger company ($7.33B vs $6.51B market cap).
- •LNTH is profitable (17.69% net margin) while IONS runs a net loss (-64.64%).
- •LNTH grew revenue faster over the past five years (32.84% vs 4.91% CAGR).
Metrics side by side
Valuation
| Metric | IONS | LNTH |
|---|---|---|
| P/E ratio | N/A | 24.14 |
| Forward P/E | N/A | 18.46 |
| P/S ratio | 8.39 | 4.18 |
| P/B ratio | 16.67 | 4.96 |
| EV / EBITDA | 2.22 | 16.99 |
| FCF yield | N/A | 5.96% |
Profitability
| Metric | IONS | LNTH |
|---|---|---|
| Gross margin | 98.16% | 60.14% |
| Operating margin | -40.47% | 19.43% |
| Net margin | -64.64% | 17.69% |
| ROE | -128.44% | 20.99% |
| ROIC | -20.37% | 11.03% |
Growth (annualized)
| Metric | IONS | LNTH |
|---|---|---|
| Revenue CAGR (5Y) | 4.91% | 32.84% |
| FCF CAGR (5Y) | N/A | 59.88% |
| Total return CAGR (5Y) | 5.82% | 31.73% |
Frequently asked
- Which has grown faster, IONS or LNTH?
- Over the past five years, LNTH grew revenue faster — IONS at a 4.91% CAGR versus LNTH at 32.84%.
- Is IONS or LNTH more profitable?
- LNTH runs the higher net margin — IONS at -64.64% versus LNTH at 17.69%.
- How have IONS and LNTH total returns compared?
- Over the past 10 years, IONS delivered 1.80% and LNTH delivered 28.40% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Lantheus P/E ratioIonis Pharmaceuticals ROELantheus ROEIonis Pharmaceuticals operating marginLantheus operating marginIonis Pharmaceuticals revenue growthLantheus revenue growthIonis Pharmaceuticals free cash flowLantheus free cash flow
Ionis Pharmaceuticals & Lantheus appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.