Basis: Trailing twelve months (TTM net income over TTM revenue). Source: stored company filings and market data; unavailable inputs remain N/A.
Is the net profit margin high or low?
The net profit margin of -418.24% is 48% above its 5-year average of -809.52%, around the middle of its 5-year range (-11391.11%–10574.69%).
29.02% above its 12-month average of -589.27%.
Reported quarterly profit margin; no daily interpolation. Q2 FY2026 (2026-06-30): -225.06%.
NET PROFIT MARGIN
-418.24%
NET PROFIT MARGIN AVG TTM
-589.27%
NET PROFIT MARGIN AVG 3Y
-901.19%
NET PROFIT MARGIN AVG 5Y
-809.52%
NET PROFIT MARGIN AVG 10Y
-581.66%
NET PROFIT MARGIN AVG 15Y
-459.82%
NET PROFIT MARGIN AVG 20Y
N/A
CURRENT VS TTM AVG
+29.02%
CURRENT VS 3Y AVG
+53.59%
CURRENT VS 5Y AVG
+48.33%
CURRENT VS 10Y AVG
+28.10%
CURRENT VS 15Y AVG
+9.04%
CURRENT VS 20Y AVG
N/A
SECTOR MEDIAN · HEALTHCARE
0.00%
median of 455 covered companies
CURRENT VS SECTOR MEDIAN
N/A
vs the sector median at left
Agios Pharmaceuticals, Inc.
Market Cap
$1.87B
Net Profit Margin
-418.24%
TTM Avg
-589.27%
3Y Avg
-901.19%
5Y Avg
-809.52%
Market Cap
$1.89B
Net Profit Margin
49.06%
TTM Avg
-18.57%
3Y Avg
-80.13%
5Y Avg
-53.74%
Market Cap
$1.83B
Net Profit Margin
1.05%
TTM Avg
1.42%
3Y Avg
2.79%
5Y Avg
2.28%
Market Cap
$1.78B
Net Profit Margin
-636.99%
TTM Avg
-743.17%
3Y Avg
-743.17%
5Y Avg
-743.17%
Market Cap
$1.78B
Net Profit Margin
-672.16%
TTM Avg
-753.31%
3Y Avg
-935.73%
5Y Avg
-797.48%
Market Cap
$1.95B
Net Profit Margin
-7756.37%
TTM Avg
-3193.87%
3Y Avg
-2536.69%
5Y Avg
-2093.05%
Market Cap
$1.96B
Net Profit Margin
-15.82%
TTM Avg
-37.57%
3Y Avg
-42.30%
5Y Avg
-41.11%
Market Cap
$1.76B
Net Profit Margin
0.89%
TTM Avg
-2.38%
3Y Avg
-5.83%
5Y Avg
-7.07%
Market Cap
$1.97B
Net Profit Margin
-20.02%
TTM Avg
-19.08%
3Y Avg
-29.38%
5Y Avg
-13.21%
| NAME | MARKET CAP | NET PROFIT MARGIN | TTM | 3Y | 5Y |
|---|---|---|---|---|---|
| Agios Pharmaceuticals, Inc. (AGIO) | $1.87B | -418.24% | -589.27% | -901.19% | -809.52% |
| BioLife Solutions, Inc. (BLFS)vs › | $1.89B | 49.06% | -18.57% | -80.13% | -53.74% |
| Astrana Health, Inc. (ASTH)vs › | $1.83B | 1.05% | 1.42% | 2.79% | 2.28% |
| Generate Biomedicines, Inc. (GENB)vs › | $1.78B | -636.99% | -743.17% | -743.17% | -743.17% |
| Intellia Therapeutics, Inc. (NTLA)vs › | $1.78B | -672.16% | -753.31% | -935.73% | -797.48% |
| Absci Corporation (ABSI)vs › | $1.95B | -7756.37% | -3193.87% | -2536.69% | -2093.05% |
| Establishment Labs Holdings Inc. (ESTA)vs › | $1.96B | -15.82% | -37.57% | -42.30% | -41.11% |
| Alignment Healthcare, Inc. (ALHC)vs › | $1.76B | 0.89% | -2.38% | -5.83% | -7.07% |
| Azenta, Inc. (AZTA)vs › | $1.97B | -20.02% | -19.08% | -29.38% | -13.21% |
| AxoGen, Inc. (AXGN)vs › | $2.00B | -13.36% | -6.14% | -11.71% | -14.87% |
Operating Margin
-873.9%
Net Profit Margin
-418.2%
Net Profit Margin = Net Income / Revenue
Net profit margin is the percentage of revenue that becomes net income after all expenses, taxes, and interest.
Expanded definitions: Investopedia, Wikipedia, Corporate Finance Institute
| DATE | NET PROFIT MARGIN |
|---|---|
| 2026-06-30 | -225.06% |
| 2026-03-31 | -477.74% |
| 2025-12-31 | -541.09% |
| 2025-09-30 | -803.05% |
| 2025-06-30 | -899.40% |
| 2025-03-31 | -1023.25% |
| 2024-12-31 | -899.56% |
| 2024-09-30 | 10574.69% |
| 2024-06-30 | -1115.71% |
| 2024-03-31 | -995.84% |
| 2023-12-31 | -1350.70% |
| 2023-09-30 | -1234.27% |
| 2023-06-30 | -1248.60% |
| 2023-03-31 | -1444.43% |
| 2022-12-31 | 847.47% |
| 2022-09-30 | -2325.00% |
| 2022-06-30 | -1644.68% |
| 2022-03-31 | -11391.11% |
| 2021-12-31 | 0.00% |
| 2021-09-30 | 0.00% |
| 2021-06-30 | 0.00% |
| 2021-03-31 | 0.00% |
| 2020-12-31 | -221.72% |
| 2020-09-30 | -285.19% |
| 2020-06-30 | -242.26% |
| 2020-03-31 | -46.22% |
| 2019-12-31 | -288.80% |
| 2019-09-30 | -407.98% |
| 2019-06-30 | -419.02% |
| 2019-03-31 | -307.93% |
| 2018-12-31 | -305.85% |
| 2018-09-30 | -622.87% |
| 2018-06-30 | -170.10% |
| 2018-03-31 | -1036.58% |
| 2017-12-31 | -900.96% |
| 2017-09-30 | -679.14% |
| 2017-06-30 | -732.26% |
| 2017-03-31 | -629.67% |
| 2016-12-31 | -249.41% |
| 2016-09-30 | -699.32% |
| 2016-06-30 | -801.85% |
| 2016-03-31 | -74.16% |
| 2015-12-31 | -653.28% |
| 2015-09-30 | -734.62% |
| 2015-06-30 | -241.30% |
| 2015-03-31 | -14.49% |
| 2014-12-31 | -182.18% |
| 2014-09-30 | 10.93% |
| 2014-06-30 | -217.52% |
| 2014-03-31 | -145.62% |
| 2013-12-31 | -183.60% |
| 2013-09-30 | -178.32% |
| 2013-06-30 | -137.52% |
| 2013-03-31 | -115.32% |
| 2012-12-31 | -84.57% |
| 2012-09-30 | -74.11% |
| 2012-06-30 | -87.67% |
| 2012-03-31 | -73.88% |
