Agios Pharmaceuticals, Inc. (AGIO) vs Alignment Healthcare, Inc. (ALHC)
A side-by-side comparison of Agios Pharmaceuticals, Inc. and Alignment Healthcare, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
AGIO
Agios Pharmaceuticals, Inc.
$31.75HealthcareDelayed quote: Oct 6, 2026, 1:55 PM EDT
ALHC
Alignment Healthcare, Inc.
$8.41HealthcareDelayed quote: Oct 6, 2026, 1:55 PM EDT
Total return — AGIO vs ALHC
growth of $100 · dividends reinvested · last 6yAGIO -37.0% (-7.4%/yr)ALHC -50.9% (-11.2%/yr)AGIO compounded faster over this window
AGIO ALHC
AGIO vs ALHC: by the numbers
- •AGIO is the larger company ($1.90B vs $1.74B market cap).
- •ALHC is profitable (0.89% net margin) while AGIO runs a net loss (-418.24%).
- •ALHC grew revenue faster over the past five years (33.83% vs 4.54% CAGR).
Metrics side by side
Valuation
| Metric | AGIO | ALHC |
|---|---|---|
| P/E ratio | N/A | 45.05 |
| Forward P/E | N/A | 46.30 |
| P/S ratio | 19.28 | 0.38 |
| P/B ratio | 1.85 | 6.58 |
| EV / EBITDA | N/A | 15.96 |
Profitability
| Metric | AGIO | ALHC |
|---|---|---|
| Gross margin | 78.67% | 12.55% |
| Operating margin | -873.87% | 1.20% |
| Net margin | -418.24% | 0.89% |
| ROE | -40.09% | 15.35% |
| ROIC | -44.21% | 9.23% |
Growth (annualized)
| Metric | AGIO | ALHC |
|---|---|---|
| Revenue CAGR (5Y) | 4.54% | 33.83% |
| Total return CAGR (5Y) | -6.59% | -12.15% |
Frequently asked
- Which has grown faster, AGIO or ALHC?
- Over the past five years, ALHC grew revenue faster — AGIO at a 4.54% CAGR versus ALHC at 33.83%.
- Is AGIO or ALHC more profitable?
- ALHC runs the higher net margin — AGIO at -418.24% versus ALHC at 0.89%.
- How have AGIO and ALHC total returns compared?
- Over the past 5 years, AGIO delivered -6.59% and ALHC delivered -12.15% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Alignment Healthcare P/E ratioAgios Pharmaceuticals ROEAlignment Healthcare ROEAgios Pharmaceuticals operating marginAlignment Healthcare operating marginAgios Pharmaceuticals revenue growthAlignment Healthcare revenue growthAgios Pharmaceuticals free cash flowAlignment Healthcare free cash flow
Agios Pharmaceuticals & Alignment Healthcare appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.