Agios Pharmaceuticals, Inc. (AGIO) vs Establishment Labs Holdings Inc. (ESTA)
A side-by-side comparison of Agios Pharmaceuticals, Inc. and Establishment Labs Holdings Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
AGIO
Agios Pharmaceuticals, Inc.
$31.76HealthcareDelayed quote: Oct 6, 2026, 12:55 PM EDT
ESTA
Establishment Labs Holdings Inc.
$64.88HealthcareDelayed quote: Oct 6, 2026, 12:55 PM EDT
Total return — AGIO vs ESTA
growth of $100 · dividends reinvested · last 8yAGIO -65.7% (-12.5%/yr)ESTA +168.6% (+13.1%/yr)ESTA compounded faster over this window
Log scale — wide-divergence pair
AGIO ESTA
AGIO vs ESTA: by the numbers
- •ESTA is the larger company ($1.91B vs $1.90B market cap).
- •Both run net losses; ESTA's is the smaller (-15.82% vs -418.24% net margin).
- •ESTA grew revenue faster over the past five years (17.02% vs 4.54% CAGR).
Metrics side by side
Valuation
| Metric | AGIO | ESTA |
|---|---|---|
| P/S ratio | 19.28 | 7.77 |
| P/B ratio | 1.85 | 88.37 |
Profitability
| Metric | AGIO | ESTA |
|---|---|---|
| Gross margin | 78.67% | 70.49% |
| Operating margin | -873.87% | -18.48% |
| Net margin | -418.24% | -15.82% |
| ROE | -40.09% | -179.99% |
| ROIC | -44.21% | -6.53% |
Growth (annualized)
| Metric | AGIO | ESTA |
|---|---|---|
| Revenue CAGR (5Y) | 4.54% | 17.02% |
| Total return CAGR (5Y) | -6.59% | -1.56% |
Frequently asked
- Which has grown faster, AGIO or ESTA?
- Over the past five years, ESTA grew revenue faster — AGIO at a 4.54% CAGR versus ESTA at 17.02%.
- How have AGIO and ESTA total returns compared?
- Over the past 5 years, AGIO delivered -6.59% and ESTA delivered -1.56% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Agios Pharmaceuticals ROEEstablishment Labs ROEAgios Pharmaceuticals operating marginEstablishment Labs operating marginAgios Pharmaceuticals revenue growthEstablishment Labs revenue growthAgios Pharmaceuticals free cash flowEstablishment Labs free cash flow
Agios Pharmaceuticals & Establishment Labs appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.