Which has grown faster, AGIO or ASTH?

Over the past five years, ASTH grew revenue faster — AGIO at a 4.54% CAGR versus ASTH at 53.77%.

Is AGIO or ASTH more profitable?

ASTH runs the higher net margin — AGIO at -418.24% versus ASTH at 1.05%.

How have AGIO and ASTH total returns compared?

Over the past 10 years, AGIO delivered -5.39% and ASTH delivered 25.17% annualized total return. Past performance doesn't predict future results.

Agios Pharmaceuticals, Inc. (AGIO) vs Astrana Health, Inc. (ASTH)

A side-by-side comparison of Agios Pharmaceuticals, Inc. and Astrana Health, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

AGIO

Agios Pharmaceuticals, Inc.

$1.86B

$31.19HealthcareDelayed quote: Oct 6, 2026, 10:05 AM EDT

ASTH

Astrana Health, Inc.

$1.85B

$37.29HealthcareDelayed quote: Oct 6, 2026, 10:05 AM EDT

Total return — AGIO vs ASTH

growth of $100 · dividends reinvested · last 10y

AGIO -41.9% (-5.3%/yr)ASTH +824.9% (+24.9%/yr)ASTH compounded faster over this window

Log scale — wide-divergence pair

AGIO ASTH

AGIO vs ASTH: by the numbers

•AGIO is the larger company ($1.86B vs $1.85B market cap).
•ASTH is profitable (1.05% net margin) while AGIO runs a net loss (-418.24%).
•ASTH grew revenue faster over the past five years (53.77% vs 4.54% CAGR).

Metrics side by side

Valuation

Metric	AGIO	ASTH
P/E ratio	N/A	45.61
Forward P/E	N/A	26.68
P/S ratio	18.94	0.48
P/B ratio	1.81	2.23
EV / EBITDA	N/A	13.57
FCF yield	N/A	8.57%

Profitability

Metric	AGIO	ASTH
Gross margin	78.67%	9.22%
Operating margin	-873.87%	2.61%
Net margin	-418.24%	1.05%
ROE	-40.09%	4.88%
ROIC	-44.21%	4.13%

Growth (annualized)

Metric	AGIO	ASTH
Revenue CAGR (5Y)	4.54%	53.77%
EPS CAGR (5Y)	N/A	-15.06%
FCF CAGR (5Y)	N/A	18.35%
Total return CAGR (5Y)	-6.59%	-16.52%

Frequently asked

Which has grown faster, AGIO or ASTH?: Over the past five years, ASTH grew revenue faster — AGIO at a 4.54% CAGR versus ASTH at 53.77%.
Is AGIO or ASTH more profitable?: ASTH runs the higher net margin — AGIO at -418.24% versus ASTH at 1.05%.
How have AGIO and ASTH total returns compared?: Over the past 10 years, AGIO delivered -5.39% and ASTH delivered 25.17% annualized total return. Past performance doesn't predict future results.

Go deeper

Full AGIO analysis Full ASTH analysis Interactive comparison tool

Dig into the metrics

Astrana Health P/E ratio Agios Pharmaceuticals ROE Astrana Health ROE Agios Pharmaceuticals operating margin Astrana Health operating margin Agios Pharmaceuticals revenue growth Astrana Health revenue growth Agios Pharmaceuticals free cash flow Astrana Health free cash flow

Agios Pharmaceuticals & Astrana Health appear in these rankings

Fastest Revenue Growth Stocks Highest FCF Yield Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.