Basis: Current FMP quote-based enterprise value / four-quarter operating income plus matched D&A. Source: stored company filings and market data; unavailable inputs remain N/A.
Is the EV/EBITDA ratio high or low?
The EV/EBITDA ratio of 141.66x is 50% above its estimated 2-year average of 94.19x, around the middle of its estimated 2-year range (8.77x–292.34x).
As of 2026-10-06T18:52:50.321Z. 35.33% below its estimated 12-month average of 219.04x.
Calculation as of: 2026-10-06T18:52:50.321Z.
Quote observation: 2026-10-06T18:50:02.000Z. Amounts in USD. The price header may show a later quote.
FMP input reference: 03323db2775440637d437753bcbe4752de1aa38160fb89fba54e51888a6c5dc1
Historical values estimate market capitalization from statement-period weighted shares. Comparisons with the current quote-based value are approximate. Only filing versions delivered by FMP are available for the historical calculation. Historical series through 2026-10-05.
Historical values estimate market capitalization from statement-period weighted shares. Comparisons with the current quote-based value are approximate. Only filing versions delivered by FMP are available for the historical calculation.
EV/EBITDA RATIO
141.66x
EV/EBITDA RATIO AVG TTM
219.04x
EV/EBITDA RATIO AVG 3Y
N/A
EV/EBITDA RATIO AVG 5Y
N/A
EV/EBITDA RATIO AVG 10Y
N/A
EV/EBITDA RATIO AVG 15Y
N/A
EV/EBITDA RATIO AVG 20Y
N/A
CURRENT VS TTM AVG
-35.33%
CURRENT VS 3Y AVG
N/A
CURRENT VS 5Y AVG
N/A
CURRENT VS 10Y AVG
N/A
CURRENT VS 15Y AVG
N/A
CURRENT VS 20Y AVG
N/A
SECTOR MEDIAN · HEALTHCARE
15.76x
median of 217 covered companies
CURRENT VS SECTOR MEDIAN
+798.86%
vs the sector median at left
Protagonist Therapeutics, Inc.
Market Cap
$8.89B
EV/EBITDA Ratio
141.66x
TTM Avg
219.04x
3Y Avg
N/A
5Y Avg
N/A
Market Cap
$8.79B
EV/EBITDA Ratio
N/A
TTM Avg
48.39x
3Y Avg
48.39x
5Y Avg
48.39x
Market Cap
$8.91B
EV/EBITDA Ratio
29.85x
TTM Avg
147.75x
3Y Avg
144.67x
5Y Avg
144.67x
Market Cap
$9.21B
EV/EBITDA Ratio
30.69x
TTM Avg
23.19x
3Y Avg
21.87x
5Y Avg
21.39x
Market Cap
$8.41B
EV/EBITDA Ratio
7.30x
TTM Avg
74.89x
3Y Avg
49.56x
5Y Avg
49.56x
| NAME | MARKET CAP | EV/EBITDA RATIO | TTM | 3Y | 5Y |
|---|---|---|---|---|---|
| Protagonist Therapeutics, Inc. (PTGX) | $8.89B | 141.66x | 219.04x | N/A | N/A |
| Arrowhead Pharmaceuticals, Inc. (ARWR)vs › | $8.79B | N/A | 48.39x | 48.39x | 48.39x |
| Bruker Corporation (BRKRP)vs › | $8.91B | 29.85x | 147.75x | 144.67x | 144.67x |
| Axsome Therapeutics, Inc. (AXSM)vs › | $9.01B | N/A | N/A | N/A | N/A |
| Kymera Therapeutics, Inc. (KYMR)vs › | $8.69B | N/A | N/A | N/A | N/A |
| Bruker Corporation (BRKR)vs › | $9.21B | 30.69x | 23.19x | 21.87x | 21.39x |
| Oscar Health, Inc. (OSCR)vs › | $8.41B | 7.30x | 74.89x | 49.56x | 49.56x |
| Insulet Corp. (PODD)vs › | $9.37B | 15.74x | 28.49x | 45.32x | 85.61x |
| Vaxcyte, Inc. (PCVX)vs › | $9.42B | N/A | N/A | N/A | N/A |
| Krystal Biotech, Inc. (KRYS)vs › | $9.62B | 45.03x | 45.64x | 58.48x | 58.48x |
At 141.7, EV/EBITDA is above its estimated 2-year median — higher than 69% of readings in its estimated 2-year history.
Historical values estimate market capitalization from statement-period weighted shares. Comparisons with the current quote-based value are approximate. Only filing versions delivered by FMP are available for the historical calculation.
estimated 2-year low
8.8
median
18.0
estimated 2-year high
292.3
EV/EBITDA = Enterprise Value / EBITDA (TTM)
Enterprise value to EBITDA is a capital-structure-neutral valuation multiple, useful for comparing companies with different debt levels and tax rates.
Expanded definitions: Investopedia, Wikipedia, Corporate Finance Institute
| DATE | EV/EBITDA RATIO |
|---|---|
| 2026-10-05 | 159.89x |
| 2026-10-02 | 159.22x |
| 2026-10-01 | 158.19x |
| 2026-09-30 | 160.20x |
| 2026-09-29 | 160.30x |
| 2026-09-28 | 162.04x |
| 2026-09-25 | 161.35x |
| 2026-09-24 | 155.99x |
| 2026-09-23 | 157.60x |
| 2026-09-22 | 165.16x |
| 2026-09-21 | 165.05x |
| 2026-09-18 | 162.70x |
| 2026-09-17 | 163.53x |
| 2026-09-16 | 162.51x |
| 2026-09-15 | 163.18x |
| 2026-09-14 | 168.37x |
| 2026-09-11 | 168.85x |
| 2026-09-10 | 165.26x |
| 2026-09-09 | 165.18x |
| 2026-09-08 | 166.19x |
| 2026-09-04 | 165.93x |
| 2026-09-03 | 169.58x |
| 2026-09-02 | 166.36x |
| 2026-09-01 | 166.84x |
| 2026-08-31 | 168.34x |
| 2026-08-28 | 164.28x |
| 2026-08-27 | 170.41x |
| 2026-08-26 | 172.78x |
| 2026-08-25 | 171.70x |
| 2026-08-24 | 176.60x |
| 2026-08-21 | 176.13x |
| 2026-08-20 | 171.82x |
| 2026-08-19 | 176.86x |
| 2026-08-18 | 179.71x |
| 2026-08-17 | 181.22x |
| 2026-08-14 | 177.05x |
| 2026-08-13 | 172.69x |
| 2026-08-12 | 173.39x |
| 2026-08-11 | 168.98x |
| 2026-08-10 | 171.00x |
| 2026-08-07 | 166.11x |
| 2026-08-06 | 166.47x |
| 2026-02-25 | 266.61x |
| 2026-02-24 | 267.51x |
| 2026-02-23 | 265.02x |
| 2026-02-20 | 253.07x |
| 2026-02-19 | 254.10x |
| 2026-02-18 | 253.79x |
| 2026-02-17 | 252.14x |
| 2026-02-13 | 249.11x |
| 2026-02-12 | 250.48x |
| 2026-02-11 | 255.35x |
| 2026-02-10 | 256.57x |
| 2026-02-09 | 254.82x |
| 2026-02-06 | 258.47x |
| 2026-02-05 | 246.55x |
| 2026-02-04 | 254.76x |
| 2026-02-03 | 261.90x |
| 2026-02-02 | 253.98x |
| 2026-01-30 | 250.08x |
| 2026-01-29 | 243.62x |
| 2026-01-28 | 249.95x |
| 2026-01-27 | 254.07x |
| 2026-01-26 | 251.64x |
| 2026-01-23 | 254.13x |
| 2026-01-22 | 259.40x |
| 2026-01-21 | 256.60x |
| 2026-01-20 | 255.13x |
| 2026-01-16 | 250.67x |
| 2026-01-15 | 259.28x |
| 2026-01-14 | 260.78x |
| 2026-01-13 | 248.71x |
| 2026-01-12 | 245.24x |
| 2026-01-09 | 245.15x |
| 2026-01-08 | 245.09x |
| 2026-01-07 | 251.76x |
| 2026-01-06 | 251.54x |
| 2026-01-05 | 257.50x |
| 2026-01-02 | 266.86x |
| 2025-12-31 | 267.36x |
| 2025-12-30 | 267.11x |
| 2025-12-29 | 269.20x |
| 2025-12-26 | 271.85x |
| 2025-12-24 | 272.03x |
| 2025-12-23 | 271.69x |
| 2025-12-22 | 267.58x |
| 2025-12-19 | 263.33x |
| 2025-12-18 | 262.52x |
| 2025-12-17 | 273.59x |
| 2025-12-16 | 280.46x |
| 2025-12-15 | 290.59x |
| 2025-12-12 | 292.34x |
| 2025-12-11 | 282.67x |
| 2025-12-10 | 279.96x |
| 2025-12-09 | 271.16x |
| 2025-12-08 | 276.43x |
| 2025-12-05 | 274.56x |
| 2025-12-04 | 267.33x |
| 2025-12-03 | 263.40x |
| 2025-12-02 | 258.97x |
| 2025-12-01 | 262.05x |
| 2025-11-28 | 275.65x |
| 2025-11-26 | 275.87x |
| 2025-11-25 | 275.22x |
| 2025-11-24 | 268.45x |
| 2025-11-21 | 261.31x |
| 2025-11-20 | 257.56x |
| 2025-11-19 | 260.46x |
| 2025-11-18 | 258.16x |
| 2025-11-17 | 259.34x |
| 2025-11-14 | 258.84x |
| 2025-11-13 | 254.57x |
| 2025-11-12 | 259.59x |
| 2025-11-11 | 261.81x |
| 2025-11-10 | 254.54x |
| 2025-11-07 | 243.03x |
| 2025-11-06 | 191.02x |
| 2025-11-05 | 186.33x |
| 2025-11-04 | 182.92x |
| 2025-11-03 | 181.56x |
| 2025-10-31 | 188.16x |
| 2025-10-30 | 186.25x |
| 2025-10-29 | 183.39x |
| 2025-10-28 | 187.88x |
| 2025-10-27 | 179.83x |
| 2025-10-24 | 178.86x |
| 2025-10-23 | 176.71x |
| 2025-10-22 | 175.50x |
| 2025-10-21 | 179.21x |
| 2025-10-20 | 183.46x |
| 2025-10-17 | 185.39x |
| 2025-10-16 | 181.01x |
| 2025-10-15 | 185.83x |
| 2025-10-14 | 184.00x |
| 2025-10-13 | 189.51x |
| 2025-10-10 | 208.86x |
| 2025-10-09 | 159.54x |
| 2025-10-08 | 155.24x |
| 2025-10-07 | 155.66x |
| 2025-10-06 | 152.37x |
| 2025-10-03 | 154.08x |
| 2025-10-02 | 154.45x |
| 2025-10-01 | 152.03x |
| 2025-09-30 | 158.03x |
| 2025-09-29 | 154.85x |
| 2025-09-26 | 160.48x |
| 2025-09-25 | 153.76x |
| 2025-09-24 | 156.85x |
| 2025-09-23 | 154.65x |
| 2025-09-22 | 153.29x |
| 2025-09-19 | 147.58x |
| 2025-09-18 | 147.43x |
| 2025-09-17 | 140.22x |
| 2025-09-16 | 138.66x |
| 2025-09-15 | 138.14x |
| 2025-09-12 | 139.33x |
| 2025-09-11 | 141.35x |
| 2025-09-10 | 136.56x |
| 2025-09-09 | 138.09x |
| 2025-09-08 | 132.73x |
| 2025-09-05 | 143.45x |
| 2025-09-04 | 141.16x |
| 2025-09-03 | 137.47x |
| 2025-09-02 | 139.30x |
| 2025-08-29 | 139.80x |
| 2025-08-28 | 137.55x |
| 2025-08-27 | 145.68x |
| 2025-08-26 | 134.71x |
| 2025-08-25 | 134.43x |
| 2025-08-22 | 135.92x |
| 2025-08-21 | 132.36x |
| 2025-08-20 | 132.83x |
| 2025-08-19 | 132.88x |
| 2025-08-18 | 132.78x |
| 2025-08-15 | 132.43x |
| 2025-08-14 | 129.76x |
| 2025-08-13 | 134.04x |
| 2025-08-12 | 128.63x |
| 2025-08-11 | 126.70x |
| 2025-08-08 | 120.08x |
| 2025-08-07 | 119.81x |
| 2025-08-06 | 108.35x |
| 2025-08-05 | 108.41x |
| 2025-08-04 | 108.26x |
| 2025-08-01 | 108.26x |
| 2025-07-31 | 108.32x |
| 2025-07-30 | 109.91x |
| 2025-07-29 | 110.73x |
| 2025-07-28 | 113.34x |
| 2025-07-25 | 111.02x |
| 2025-07-24 | 108.07x |
| 2025-07-23 | 109.01x |
| 2025-07-22 | 110.69x |
| 2025-07-21 | 111.17x |
| 2025-07-18 | 111.71x |
| 2025-07-17 | 113.72x |
| 2025-07-16 | 114.14x |
| 2025-07-15 | 111.38x |
| 2025-07-14 | 111.19x |
| 2025-07-11 | 106.53x |
| 2025-07-10 | 106.17x |
| 2025-07-09 | 105.04x |
| 2025-07-08 | 99.63x |
| 2025-07-07 | 99.98x |
| 2025-07-03 | 102.45x |
| 2025-07-02 | 101.70x |
| 2025-07-01 | 100.69x |
| 2025-06-30 | 111.27x |
| 2025-06-27 | 112.15x |
| 2025-06-26 | 111.17x |
| 2025-06-25 | 109.54x |
| 2025-06-24 | 107.95x |
| 2025-06-23 | 107.28x |
| 2025-06-20 | 107.24x |
| 2025-06-18 | 108.45x |
| 2025-06-17 | 111.15x |
| 2025-06-16 | 110.00x |
| 2025-06-13 | 113.57x |
| 2025-06-12 | 113.47x |
| 2025-06-11 | 111.42x |
| 2025-06-10 | 113.57x |
| 2025-06-09 | 112.13x |
| 2025-06-06 | 109.41x |
| 2025-06-05 | 108.24x |
| 2025-06-04 | 103.45x |
| 2025-06-03 | 102.47x |
| 2025-06-02 | 100.57x |
| 2025-05-30 | 94.97x |
| 2025-05-29 | 95.20x |
| 2025-05-28 | 91.37x |
| 2025-05-27 | 92.79x |
| 2025-05-23 | 91.18x |
| 2025-05-22 | 91.71x |
| 2025-05-21 | 91.52x |
| 2025-05-20 | 93.17x |
| 2025-05-19 | 91.00x |
| 2025-05-16 | 88.74x |
| 2025-05-15 | 88.57x |
| 2025-05-14 | 87.23x |
| 2025-05-13 | 88.28x |
| 2025-05-12 | 90.37x |
| 2025-05-09 | 85.56x |
| 2025-05-08 | 87.55x |
| 2025-05-07 | 85.81x |
| 2025-05-06 | 10.57x |
| 2025-05-05 | 11.16x |
| 2025-05-02 | 11.48x |
| 2025-05-01 | 11.34x |
| 2025-04-30 | 11.56x |
| 2025-04-29 | 11.51x |
| 2025-04-28 | 11.19x |
| 2025-04-25 | 11.21x |
| 2025-04-24 | 11.31x |
| 2025-04-23 | 11.65x |
| 2025-04-22 | 11.57x |
| 2025-04-21 | 11.55x |
| 2025-04-17 | 11.68x |
| 2025-04-16 | 11.55x |
| 2025-04-15 | 11.85x |
| 2025-04-14 | 11.36x |
Showing the most recent 260 of 493 data points. The chart above shows the full history.
