Is AXSM or PTGX more profitable?

PTGX runs the higher net margin — AXSM at -24.68% versus PTGX at 29.40%.

How have AXSM and PTGX total returns compared?

Over the past 10 years, AXSM delivered 35.76% and PTGX delivered 20.54% annualized total return. Past performance doesn't predict future results.

Axsome Therapeutics, Inc. (AXSM) vs Protagonist Therapeutics, Inc. (PTGX)

A side-by-side comparison of Axsome Therapeutics, Inc. and Protagonist Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

AXSM

Axsome Therapeutics, Inc.

$9.00B

$174.95HealthcareDelayed quote: Oct 6, 2026, 1:55 PM EDT

PTGX

Protagonist Therapeutics, Inc.

$8.79B

$136.63HealthcareDelayed quote: Oct 6, 2026, 1:55 PM EDT

Total return — AXSM vs PTGX

growth of $100 · dividends reinvested · last 10y

AXSM +2067.4% (+36.0%/yr)PTGX +574.2% (+21.0%/yr)AXSM compounded faster over this window

AXSM PTGX

AXSM vs PTGX: by the numbers

•AXSM is the larger company ($9.00B vs $8.79B market cap).
•PTGX is profitable (29.40% net margin) while AXSM runs a net loss (-24.68%).

Metrics side by side

Valuation

Metric	AXSM	PTGX
P/E ratio	N/A	132.18
P/S ratio	11.59	31.16
P/B ratio	108.07	10.44
EV / EBITDA	N/A	139.87
FCF yield	N/A	1.49%

Profitability

Metric	AXSM	PTGX
Gross margin	93.24%	99.86%
Operating margin	-24.28%	-343.63%
Net margin	-24.68%	29.40%
ROE	-230.05%	9.85%
ROIC	-50.82%	6.74%

Growth (annualized)

Metric	AXSM	PTGX
Revenue CAGR (5Y)	N/A	59.63%
Total return CAGR (5Y)	41.40%	50.88%

Frequently asked

Is AXSM or PTGX more profitable?: PTGX runs the higher net margin — AXSM at -24.68% versus PTGX at 29.40%.
How have AXSM and PTGX total returns compared?: Over the past 10 years, AXSM delivered 35.76% and PTGX delivered 20.54% annualized total return. Past performance doesn't predict future results.

Go deeper

Full AXSM analysis Full PTGX analysis Interactive comparison tool

Dig into the metrics

Protagonist Therapeutics P/E ratio Axsome Therapeutics ROE Protagonist Therapeutics ROE Axsome Therapeutics operating margin Protagonist Therapeutics operating margin Axsome Therapeutics revenue growth Protagonist Therapeutics revenue growth Axsome Therapeutics free cash flow Protagonist Therapeutics free cash flow

Axsome Therapeutics & Protagonist Therapeutics appear in these rankings

Fastest Revenue Growth Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.