Which has grown faster, ARWR or PTGX?

Over the past five years, PTGX grew revenue faster — ARWR at a 44.14% CAGR versus PTGX at 59.63%.

Is ARWR or PTGX more profitable?

PTGX runs the higher net margin — ARWR at -47.79% versus PTGX at 29.40%.

How have ARWR and PTGX total returns compared?

Over the past 10 years, ARWR delivered 23.56% and PTGX delivered 20.54% annualized total return. Past performance doesn't predict future results.

Arrowhead Pharmaceuticals, Inc. (ARWR) vs Protagonist Therapeutics, Inc. (PTGX)

A side-by-side comparison of Arrowhead Pharmaceuticals, Inc. and Protagonist Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ARWR

Arrowhead Pharmaceuticals, Inc.

$8.63B

$61.30HealthcareDelayed quote: Oct 6, 2026, 3:40 PM EDT

PTGX

Protagonist Therapeutics, Inc.

$8.88B

$138.03HealthcareDelayed quote: Oct 6, 2026, 3:35 PM EDT

Total return — ARWR vs PTGX

growth of $100 · dividends reinvested · last 10y

ARWR +755.3% (+23.9%/yr)PTGX +574.2% (+21.0%/yr)ARWR compounded faster over this window

ARWR PTGX

ARWR vs PTGX: by the numbers

•PTGX is the larger company ($8.88B vs $8.63B market cap).
•PTGX is profitable (29.40% net margin) while ARWR runs a net loss (-47.79%).
•PTGX grew revenue faster over the past five years (59.63% vs 44.14% CAGR).

Metrics side by side

Valuation

Metric	ARWR	PTGX
P/E ratio	N/A	133.53
P/S ratio	12.90	31.48
P/B ratio	18.55	10.55
EV / EBITDA	N/A	141.38
FCF yield	N/A	1.47%

Profitability

Metric	ARWR	PTGX
Gross margin	100.00%	99.86%
Operating margin	11.86%	-343.63%
Net margin	-47.79%	29.40%
ROE	-68.73%	9.85%
ROIC	-12.12%	6.74%

Growth (annualized)

Metric	ARWR	PTGX
Revenue CAGR (5Y)	44.14%	59.63%
Total return CAGR (5Y)	0.75%	50.88%

Frequently asked

Which has grown faster, ARWR or PTGX?: Over the past five years, PTGX grew revenue faster — ARWR at a 44.14% CAGR versus PTGX at 59.63%.
Is ARWR or PTGX more profitable?: PTGX runs the higher net margin — ARWR at -47.79% versus PTGX at 29.40%.
How have ARWR and PTGX total returns compared?: Over the past 10 years, ARWR delivered 23.56% and PTGX delivered 20.54% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ARWR analysis Full PTGX analysis Interactive comparison tool

Dig into the metrics

Protagonist Therapeutics P/E ratio Arrowhead Pharmaceuticals ROE Protagonist Therapeutics ROE Arrowhead Pharmaceuticals operating margin Protagonist Therapeutics operating margin Arrowhead Pharmaceuticals revenue growth Protagonist Therapeutics revenue growth Arrowhead Pharmaceuticals free cash flow Protagonist Therapeutics free cash flow

Arrowhead Pharmaceuticals & Protagonist Therapeutics appear in these rankings

Fastest Revenue Growth Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.