Rhythm Pharmaceuticals (RYTM) EV/EBITDA: History & Chart

Rhythm Pharmaceuticals, Inc.(RYTM)

Biotechnology · Boston, MA

$90.20-2.25 (-2.43%)

Delayed quote: Oct 6, 2026, 1:55 PM EDT

About Rhythm Pharmaceuticals, Inc.

Rhythm Pharmaceuticals, Inc. is a biopharmaceutical company with commercial products, dedicated to the discovery, development, and market launch of therapies addressing rare genetic conditions that cause obesity. Its leading pharmaceutical, IMCIVREE, functions as a powerful agonist of the melanocortin-4 receptor (MC4R). This medication is indicated for treating obesity stemming from deficiencies in pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or the leptin receptor (LEPR), alongside its use in patients with Bardet-Biedl and Alström syndromes. Furthermore, the company is progressing setmelanotide (the active compound in IMCIVREE) through Phase II clinical trials. These studies are evaluating its potential for a broader spectrum of applications, including obesity caused by heterozygous POMC or LEPR deficiencies, steroid receptor coactivator 1 (SRC1) deficiency, SH2B1 deficiency, MC4 receptor deficiency, and obesity associated with Smith-Magenis syndrome, POMC epigenetic disorders, and other MC4R-related conditions. Rhythm Pharmaceuticals holds a collaborative research agreement with the Clinical Registry Investigating Bardet-Biedl Syndrome. The firm, headquartered in Boston, Massachusetts, was established in 2008 and changed its name from Rhythm Metabolic, Inc. to Rhythm Pharmaceuticals, Inc. in October 2015.

Boston, MA

414 employees

www.rhythmtx.com

Healthcare / Biotechnology

Sector: Healthcare
Industry: Biotechnology
CEO: David Meeker

View full financials

NAME	MARKET CAP	EV/EBITDA RATIO	TTM	3Y	5Y
Rhythm Pharmaceuticals, Inc. (RYTM)	$6.19B	N/A	N/A	N/A	N/A
GRAIL Inc. (GRAL)vs ›	$6.02B	N/A	N/A	N/A	N/A
Iovance Biotherapeutics, Inc. (IOVA)vs ›	$5.91B	N/A	N/A	N/A	N/A
Ligand Pharmaceuticals Incorporated (LGND)vs ›	$5.90B	44.67x	617.82x	545.60x	321.06x
Amneal Pharmaceuticals, Inc. (AMRX)vs ›	$6.49B	15.32x	12.72x	11.11x	13.30x
Immunovant, Inc. (IMVT)vs ›	$6.50B	N/A	N/A	N/A	N/A
Lantheus Holdings, Inc. (LNTH)vs ›	$6.51B	16.99x	14.43x	16.48x	56.22x
Hims & Hers Health, Inc. (HIMS)vs ›	$6.52B	N/A	64.66x	316.14x	316.14x
Kodiak Sciences Inc. (KOD)vs ›	$5.82B	N/A	N/A	N/A	N/A
Kiniksa Pharmaceuticals International, plc (KNSA)vs ›	$5.78B	54.98x	88.38x	133.43x	103.02x

NAME

MARKET CAP

EV/EBITDA RATIO

TTM

Rhythm Pharmaceuticals, Inc. (RYTM)

$6.19B

N/A

GRAIL Inc. (GRAL)vs ›

$6.02B

N/A

Iovance Biotherapeutics, Inc. (IOVA)vs ›

$5.91B