Iovance Biotherapeutics, Inc. (IOVA) vs Rhythm Pharmaceuticals, Inc. (RYTM)
A side-by-side comparison of Iovance Biotherapeutics, Inc. and Rhythm Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
IOVA
Iovance Biotherapeutics, Inc.
$12.96HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
RYTM
Rhythm Pharmaceuticals, Inc.
$90.77HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
Total return — IOVA vs RYTM
growth of $100 · dividends reinvested · last 9yIOVA +78.0% (+6.6%/yr)RYTM +208.2% (+13.3%/yr)RYTM compounded faster over this window
IOVA RYTM
IOVA vs RYTM: by the numbers
- •RYTM is the larger company ($6.23B vs $5.79B market cap).
- •Both run net losses; RYTM's is the smaller (-85.59% vs -89.09% net margin).
Metrics side by side
Valuation
| Metric | IOVA | RYTM |
|---|---|---|
| P/S ratio | 17.81 | 25.95 |
| P/B ratio | 7.86 | 60.46 |
Profitability
| Metric | IOVA | RYTM |
|---|---|---|
| Gross margin | 97.23% | 89.00% |
| Operating margin | -153.08% | -101.19% |
| Net margin | -89.09% | -85.59% |
| ROE | -39.33% | -94.50% |
| ROIC | -37.26% | -63.96% |
Growth (annualized)
| Metric | IOVA | RYTM |
|---|---|---|
| Revenue CAGR (5Y) | N/A | 278.53% |
| Total return CAGR (5Y) | -11.55% | 49.95% |
Frequently asked
- How have IOVA and RYTM total returns compared?
- Over the past 5 years, IOVA delivered -11.55% and RYTM delivered 49.95% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Iovance Biotherapeutics ROERhythm Pharmaceuticals ROEIovance Biotherapeutics operating marginRhythm Pharmaceuticals operating marginIovance Biotherapeutics revenue growthRhythm Pharmaceuticals revenue growthIovance Biotherapeutics free cash flowRhythm Pharmaceuticals free cash flow
Iovance Biotherapeutics & Rhythm Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.