Which has grown faster, KNSA or RYTM?

Over the past five years, RYTM grew revenue faster — KNSA at a 155.66% CAGR versus RYTM at 278.53%.

Is KNSA or RYTM more profitable?

KNSA runs the higher net margin — KNSA at 9.59% versus RYTM at -85.59%.

How have KNSA and RYTM total returns compared?

Over the past 5 years, KNSA delivered 47.48% and RYTM delivered 49.95% annualized total return. Past performance doesn't predict future results.

Kiniksa Pharmaceuticals International, plc (KNSA) vs Rhythm Pharmaceuticals, Inc. (RYTM)

A side-by-side comparison of Kiniksa Pharmaceuticals International, plc and Rhythm Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

KNSA

Kiniksa Pharmaceuticals International, plc

$5.88B

$77.19HealthcareDelayed quote: Oct 6, 2026, 3:20 PM EDT

RYTM

Rhythm Pharmaceuticals, Inc.

$6.20B

$90.37HealthcareDelayed quote: Oct 6, 2026, 3:20 PM EDT

Total return — KNSA vs RYTM

growth of $100 · dividends reinvested · last 8y

KNSA +291.9% (+18.6%/yr)RYTM +205.3% (+15.0%/yr)KNSA compounded faster over this window

KNSA RYTM

KNSA vs RYTM: by the numbers

•RYTM is the larger company ($6.20B vs $5.88B market cap).
•KNSA is profitable (9.59% net margin) while RYTM runs a net loss (-85.59%).
•RYTM grew revenue faster over the past five years (278.53% vs 155.66% CAGR).

Metrics side by side

Valuation

Metric	KNSA	RYTM
P/E ratio	78.77	N/A
Forward P/E	55.42	N/A
P/S ratio	7.00	25.84
P/B ratio	8.99	60.19
EV / EBITDA	56.01	N/A
FCF yield	3.11%	N/A

Profitability

Metric	KNSA	RYTM
Gross margin	54.49%	89.00%
Operating margin	11.92%	-101.19%
Net margin	9.59%	-85.59%
ROE	12.33%	-94.50%
ROIC	9.76%	-63.96%

Growth (annualized)

Metric	KNSA	RYTM
Revenue CAGR (5Y)	155.66%	278.53%
Total return CAGR (5Y)	47.48%	49.95%

Frequently asked

Which has grown faster, KNSA or RYTM?: Over the past five years, RYTM grew revenue faster — KNSA at a 155.66% CAGR versus RYTM at 278.53%.
Is KNSA or RYTM more profitable?: KNSA runs the higher net margin — KNSA at 9.59% versus RYTM at -85.59%.
How have KNSA and RYTM total returns compared?: Over the past 5 years, KNSA delivered 47.48% and RYTM delivered 49.95% annualized total return. Past performance doesn't predict future results.

Go deeper

Full KNSA analysis Full RYTM analysis Interactive comparison tool

Dig into the metrics

Kiniksa Pharmaceuticals International P/E ratio Kiniksa Pharmaceuticals International ROE Rhythm Pharmaceuticals ROE Kiniksa Pharmaceuticals International operating margin Rhythm Pharmaceuticals operating margin Kiniksa Pharmaceuticals International revenue growth Rhythm Pharmaceuticals revenue growth Kiniksa Pharmaceuticals International free cash flow Rhythm Pharmaceuticals free cash flow

Kiniksa Pharmaceuticals International & Rhythm Pharmaceuticals appear in these rankings

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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.