Which has grown faster, LGND or RYTM?

Over the past five years, RYTM grew revenue faster — LGND at a 2.92% CAGR versus RYTM at 278.53%.

Is LGND or RYTM more profitable?

LGND runs the higher net margin — LGND at 67.88% versus RYTM at -85.59%.

How have LGND and RYTM total returns compared?

Over the past 5 years, LGND delivered 30.72% and RYTM delivered 49.95% annualized total return. Past performance doesn't predict future results.

Ligand Pharmaceuticals Incorporated (LGND) vs Rhythm Pharmaceuticals, Inc. (RYTM)

A side-by-side comparison of Ligand Pharmaceuticals Incorporated and Rhythm Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

LGND

Ligand Pharmaceuticals Incorporated

$5.94B

$296.60HealthcareDelayed quote: Oct 6, 2026, 1:00 PM EDT

RYTM

Rhythm Pharmaceuticals, Inc.

$6.23B

$90.84HealthcareDelayed quote: Oct 6, 2026, 1:00 PM EDT

Total return — LGND vs RYTM

growth of $100 · dividends reinvested · last 9y

LGND +265.1% (+15.5%/yr)RYTM +208.2% (+13.3%/yr)LGND compounded faster over this window

LGND RYTM

LGND vs RYTM: by the numbers

•RYTM is the larger company ($6.23B vs $5.94B market cap).
•LGND is profitable (67.88% net margin) while RYTM runs a net loss (-85.59%).
•RYTM grew revenue faster over the past five years (278.53% vs 2.92% CAGR).

Metrics side by side

Valuation

Metric	LGND	RYTM
P/E ratio	31.72	N/A
Forward P/E	31.87	N/A
P/S ratio	20.46	25.97
P/B ratio	6.14	60.50
EV / EBITDA	44.97	N/A
FCF yield	2.21%	N/A

Profitability

Metric	LGND	RYTM
Gross margin	98.58%	89.00%
Operating margin	17.61%	-101.19%
Net margin	67.88%	-85.59%
ROE	20.38%	-94.50%
ROIC	3.91%	-63.96%

Growth (annualized)

Metric	LGND	RYTM
Revenue CAGR (5Y)	2.92%	278.53%
FCF CAGR (5Y)	-0.49%	N/A
Total return CAGR (5Y)	30.72%	49.95%

Frequently asked

Which has grown faster, LGND or RYTM?: Over the past five years, RYTM grew revenue faster — LGND at a 2.92% CAGR versus RYTM at 278.53%.
Is LGND or RYTM more profitable?: LGND runs the higher net margin — LGND at 67.88% versus RYTM at -85.59%.
How have LGND and RYTM total returns compared?: Over the past 5 years, LGND delivered 30.72% and RYTM delivered 49.95% annualized total return. Past performance doesn't predict future results.

Go deeper

Full LGND analysis Full RYTM analysis Interactive comparison tool

Dig into the metrics

Ligand Pharmaceuticals P/E ratio Ligand Pharmaceuticals ROE Rhythm Pharmaceuticals ROE Ligand Pharmaceuticals operating margin Rhythm Pharmaceuticals operating margin Ligand Pharmaceuticals revenue growth Rhythm Pharmaceuticals revenue growth Ligand Pharmaceuticals free cash flow Rhythm Pharmaceuticals free cash flow

Ligand Pharmaceuticals & Rhythm Pharmaceuticals appear in these rankings

Fastest Revenue Growth Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.