Basis: Trailing twelve months (TTM). Source: stored company filings and market data; unavailable inputs remain N/A.
Is the operating margin high or low?
The operating margin of -4498.06% is 134% below its 5-year average of -1923.53%, near the high end of its 5-year range (-25948.33%–0.00%).
8.81% above its 12-month average of -4932.40%.
Reported quarterly operating margin; no daily interpolation. Q2 FY2026 (2026-06-30): -3750.87%.
OPERATING MARGIN
-4498.06%
OPERATING MARGIN AVG TTM
-4932.40%
OPERATING MARGIN AVG 3Y
-3205.88%
OPERATING MARGIN AVG 5Y
-1923.53%
OPERATING MARGIN AVG 10Y
N/A
OPERATING MARGIN AVG 15Y
N/A
OPERATING MARGIN AVG 20Y
N/A
CURRENT VS TTM AVG
+8.81%
CURRENT VS 3Y AVG
-40.31%
CURRENT VS 5Y AVG
-133.84%
CURRENT VS 10Y AVG
N/A
CURRENT VS 15Y AVG
N/A
CURRENT VS 20Y AVG
N/A
SECTOR MEDIAN · HEALTHCARE
0.00%
median of 863 covered companies
CURRENT VS SECTOR MEDIAN
N/A
vs the sector median at left
Prime Medicine, Inc.
Market Cap
$632.16M
Operating Margin
-4498.06%
TTM Avg
-4932.40%
3Y Avg
-3205.88%
5Y Avg
-1923.53%
Market Cap
$630.63M
Operating Margin
-383.15%
TTM Avg
-332.73%
3Y Avg
-228.44%
5Y Avg
-187.72%
Market Cap
$634.30M
Operating Margin
-3.98%
TTM Avg
-186.23%
3Y Avg
-243.00%
5Y Avg
-164.54%
Market Cap
$638.20M
Operating Margin
0.00%
TTM Avg
0.00%
3Y Avg
0.00%
5Y Avg
0.00%
Market Cap
$619.15M
Operating Margin
-85.01%
TTM Avg
-96.97%
3Y Avg
-124.64%
5Y Avg
-134.49%
Market Cap
$656.59M
Operating Margin
-187.24%
TTM Avg
-253932.81%
3Y Avg
-127981.70%
5Y Avg
-85456.42%
Market Cap
$657.89M
Operating Margin
-4.44%
TTM Avg
-7.18%
3Y Avg
-7.18%
5Y Avg
-7.18%
| NAME | MARKET CAP | OPERATING MARGIN | TTM | 3Y | 5Y |
|---|---|---|---|---|---|
| Prime Medicine, Inc. (PRME) | $632.16M | -4498.06% | -4932.40% | -3205.88% | -1923.53% |
| OmniAb, Inc. (OABI)vs › | $630.63M | -383.15% | -332.73% | -228.44% | -187.72% |
| Zevra Therapeutics, Inc. (ZVRA)vs › | $634.30M | -3.98% | -186.23% | -243.00% | -164.54% |
| Aura Biosciences, Inc. (AURA)vs › | $638.20M | 0.00% | 0.00% | 0.00% | 0.00% |
| SOPHiA GENETICS S.A. (SOPH)vs › | $619.15M | -85.01% | -96.97% | -124.64% | -134.49% |
| Climb Bio, Inc. (CLYM)vs › | $611.57M | 0.00% | 0.00% | 0.00% | 0.00% |
| 4D Molecular Therapeutics, Inc. (FDMT)vs › | $656.59M | -187.24% | -253932.81% | -127981.70% | -85456.42% |
| Starling Oncology, Inc. (STLN)vs › | $657.89M | -4.44% | -7.18% | -7.18% | -7.18% |
| Annexon, Inc. (ANNX)vs › | $660.29M | 0.00% | 0.00% | 0.00% | 0.00% |
| Ironwood Pharmaceuticals, Inc. (IRWD)vs › | $597.55M | 40.10% | 33.30% | -21.49% | 1.14% |
Gross Margin
-58.0%
Operating Margin
-4498.1%
Operating Margin = Operating Income / Revenue
Operating margin is the percentage of revenue remaining after operating expenses, reflecting operating efficiency.
Expanded definitions: Investopedia, Wikipedia, Corporate Finance Institute
| DATE | OPERATING MARGIN |
|---|---|
| 2026-06-30 | -3750.87% |
| 2026-03-31 | -5917.52% |
| 2025-12-31 | -5800.48% |
| 2025-09-30 | -4405.96% |
| 2025-06-30 | -4787.17% |
| 2025-03-31 | -3603.30% |
| 2024-12-31 | -2025.74% |
| 2024-09-30 | -25948.33% |
| 2024-06-30 | 0.00% |
| 2024-03-31 | -8179.53% |
| 2023-12-31 | 0.00% |
| 2023-09-30 | 0.00% |
| 2023-06-30 | 0.00% |
| 2023-03-31 | 0.00% |
| 2022-12-31 | 0.00% |
| 2022-09-30 | 0.00% |
| 2022-06-30 | 0.00% |
| 2022-03-31 | 0.00% |
| 2021-12-31 | 0.00% |
| 2021-09-30 | 0.00% |
| 2021-06-30 | 0.00% |
| 2021-03-31 | 0.00% |
| 2020-12-31 | 0.00% |
| 2019-12-31 | 0.00% |
