Prime Medicine, Inc. (PRME) vs Zevra Therapeutics, Inc. (ZVRA)
A side-by-side comparison of Prime Medicine, Inc. and Zevra Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
PRME
Prime Medicine, Inc.
$3.50HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
ZVRA
Zevra Therapeutics, Inc.
$10.73HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT
Total return — PRME vs ZVRA
growth of $100 · dividends reinvested · last 4yPRME -79.1% (-32.4%/yr)ZVRA +95.6% (+18.3%/yr)ZVRA compounded faster over this window
Log scale — wide-divergence pair
PRME ZVRA
PRME vs ZVRA: by the numbers
- •ZVRA is the larger company ($634M vs $632M market cap).
- •ZVRA is profitable (42.82% net margin) while PRME runs a net loss (-4613.11%).
- •ZVRA grew revenue faster over the past five years (36.81% vs -2.32% CAGR).
Metrics side by side
Valuation
| Metric | PRME | ZVRA |
|---|---|---|
| P/E ratio | N/A | 11.53 |
| Forward P/E | N/A | 9.68 |
| P/S ratio | 155.21 | 4.66 |
| P/B ratio | 15.88 | 2.91 |
| EV / EBITDA | N/A | 12.11 |
| FCF yield | N/A | 5.13% |
Profitability
| Metric | PRME | ZVRA |
|---|---|---|
| Gross margin | -58.05% | 84.52% |
| Operating margin | -4498.06% | -3.98% |
| Net margin | -4613.11% | 42.82% |
| ROE | -471.98% | 26.77% |
| ROIC | -90.42% | 12.93% |
Growth (annualized)
| Metric | PRME | ZVRA |
|---|---|---|
| Revenue CAGR (5Y) | -2.32% | 36.81% |
| Total return CAGR (5Y) | N/A | 3.75% |
Frequently asked
- Which has grown faster, PRME or ZVRA?
- Over the past five years, ZVRA grew revenue faster — PRME at a -2.32% CAGR versus ZVRA at 36.81%.
- Is PRME or ZVRA more profitable?
- ZVRA runs the higher net margin — PRME at -4613.11% versus ZVRA at 42.82%.
Go deeper
Dig into the metrics
Zevra Therapeutics P/E ratioPrime Medicine ROEZevra Therapeutics ROEPrime Medicine operating marginZevra Therapeutics operating marginPrime Medicine revenue growthZevra Therapeutics revenue growthPrime Medicine free cash flowZevra Therapeutics free cash flow
Prime Medicine & Zevra Therapeutics appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.