Which has grown faster, IRWD or PRME?

Neither grew: over the past five years both shrank revenue, with IRWD's decline the smaller — IRWD at a -1.18% CAGR versus PRME at -2.32%.

Is IRWD or PRME more profitable?

IRWD runs the higher net margin — IRWD at 33.36% versus PRME at -4613.11%.

Ironwood Pharmaceuticals, Inc. (IRWD) vs Prime Medicine, Inc. (PRME)

A side-by-side comparison of Ironwood Pharmaceuticals, Inc. and Prime Medicine, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

IRWD

Ironwood Pharmaceuticals, Inc.

$600M

$3.65HealthcareDelayed quote: Oct 6, 2026, 1:50 PM EDT

PRME

Prime Medicine, Inc.

$628M

$3.48HealthcareDelayed quote: Oct 6, 2026, 1:50 PM EDT

Total return — IRWD vs PRME

growth of $100 · dividends reinvested · last 4y

IRWD -63.6% (-22.3%/yr)PRME -79.1% (-32.4%/yr)IRWD compounded faster over this window

IRWD PRME

IRWD vs PRME: by the numbers

•PRME is the larger company ($628M vs $600M market cap).
•IRWD is profitable (33.36% net margin) while PRME runs a net loss (-4613.11%).
•Both shrank revenue over the past five years; IRWD's decline was smaller (-1.18% vs -2.32% CAGR).

Metrics side by side

Valuation

Metric	IRWD	PRME
P/E ratio	4.75	N/A
Forward P/E	2.98	N/A
P/S ratio	1.54	154.30
P/B ratio	N/A	15.79
EV / EBITDA	3.86	N/A
FCF yield	30.92%	N/A

Profitability

Metric	IRWD	PRME
Gross margin	99.76%	-58.05%
Operating margin	40.10%	-4498.06%
Net margin	33.36%	-4613.11%
ROE	N/A	-471.98%
ROIC	58.60%	-90.42%

Growth (annualized)

Metric	IRWD	PRME
Revenue CAGR (5Y)	-1.18%	-2.32%
EPS CAGR (5Y)	-25.87%	N/A
FCF CAGR (5Y)	-3.98%	N/A
Total return CAGR (5Y)	-22.82%	N/A

Frequently asked

Which has grown faster, IRWD or PRME?: Neither grew: over the past five years both shrank revenue, with IRWD's decline the smaller — IRWD at a -1.18% CAGR versus PRME at -2.32%.
Is IRWD or PRME more profitable?: IRWD runs the higher net margin — IRWD at 33.36% versus PRME at -4613.11%.

Go deeper

Full IRWD analysis Full PRME analysis Interactive comparison tool

Dig into the metrics

Ironwood Pharmaceuticals P/E ratio Ironwood Pharmaceuticals ROE Prime Medicine ROE Ironwood Pharmaceuticals operating margin Prime Medicine operating margin Ironwood Pharmaceuticals revenue growth Prime Medicine revenue growth Ironwood Pharmaceuticals free cash flow Prime Medicine free cash flow

Ironwood Pharmaceuticals & Prime Medicine appear in these rankings

Highest ROIC Stocks Highest Operating Margin Stocks Highest FCF Yield Stocks Lowest P/E Ratio Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.