OPKO Health (OPK) ROIC: History & Chart

Name: OPKO Health, Inc. (OPK) Return on Invested Capital (ROIC) — historical time series
Creator: TGMCharts

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OPKO Health, Inc.(OPK)

Medical - Diagnostics & Research · Miami, FL

$1.46-0.11 (-7.01%)

Delayed quote: Oct 6, 2026, 4:00 PM EDT

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About OPKO Health, Inc.

OPKO Health, Inc. operates as a healthcare enterprise with a dual focus on diagnostics and pharmaceuticals. Its operations span the United States, Ireland, Chile, Spain, Israel, Mexico, and other international markets. The company's Diagnostics division encompasses BioReference Laboratories, which delivers a comprehensive suite of laboratory testing services. These services are crucial for disease detection, diagnosis, evaluation, monitoring, and treatment, covering areas such as esoteric testing, molecular diagnostics, anatomical pathology, genetics, women's health, and correctional healthcare. BioReference serves a diverse client base, including medical practices, clinics, hospitals, employers, and government entities. Additionally, this segment provides a cutting-edge diagnostic instrument system designed for immediate, point-of-care blood test results, alongside its specialized 4Kscore testing for prostate cancer. Within the Pharmaceutical segment, OPKO offers a range of therapeutic products and a robust development pipeline. Key offerings include Rayaldee, indicated for the management of secondary hyperparathyroidism in adults suffering from stage 3 or 4 chronic kidney disease and vitamin D insufficiency. The pipeline features OPK88004, an investigational orally administered selective androgen receptor modulator; OPK88003, a peptide administered once weekly currently in Phase IIb trials for the treatment of type 2 diabetes and obesity; and hGH-CTP, a once-weekly human growth hormone injection that has successfully completed Phase III clinical trials in collaboration with Pfizer, Inc. A core strategy for this segment involves the development and commercialization of proprietary, extended-release versions of existing therapeutic proteins. Furthermore, OPKO Health supplies specialty active pharmaceutical ingredients (APIs) and is involved in the development, manufacturing, marketing, and sale of pharmaceutical, nutraceutical, veterinary, and ophthalmic products. The company also commercializes food supplements and over-the-counter products, produces and sells items primarily within the generics market, and handles the import, marketing, distribution, and sales of pharmaceutical products across various therapeutic areas, including cardiovascular conditions, vaccines, antibiotics, gastro-intestinal ailments, and hormone-related treatments, among others. Its pharmaceutical operations are further bolstered by platforms situated in Ireland, Chile, Spain, and Mexico. Founded in 1991, OPKO Health, Inc. maintains its corporate headquarters in Miami, Florida.

Miami, FL

2,275 employees

www.opko.com

Healthcare / Medical - Diagnostics & Research

Sector: Healthcare
Industry: Medical - Diagnostics & Research
CEO: Phillip Frost

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OPK Return on Invested Capital (ROIC) Metrics

RETURN ON INVESTED CAPITAL (ROIC)

-8.86%

RETURN ON INVESTED CAPITAL (ROIC) AVG TTM

-10.49%

RETURN ON INVESTED CAPITAL (ROIC) AVG 3Y

-9.79%

RETURN ON INVESTED CAPITAL (ROIC) AVG 5Y

-9.38%

RETURN ON INVESTED CAPITAL (ROIC) AVG 10Y

-7.88%

RETURN ON INVESTED CAPITAL (ROIC) AVG 15Y

-8.23%

RETURN ON INVESTED CAPITAL (ROIC) AVG 20Y

-8.92%

CURRENT VS TTM AVG

+15.52%

CURRENT VS 3Y AVG

+9.48%

CURRENT VS 5Y AVG

+5.50%

CURRENT VS 10Y AVG

-12.53%

CURRENT VS 15Y AVG

-7.62%

CURRENT VS 20Y AVG

+0.59%

SECTOR MEDIAN · HEALTHCARE

-35.66%

median of 837 covered companies

CURRENT VS SECTOR MEDIAN

+75.15%

vs the sector median at left

NAME	MARKET CAP	RETURN ON INVESTED CAPITAL (ROIC)	TTM	3Y	5Y
OPKO Health, Inc. (OPK)	$1.09B	-8.86%	-10.49%	-9.79%	-9.38%
Bicara Therapeutics Inc. Common Stock (BCAX)vs ›	$1.09B	-42.98%	-26.82%	-23.95%	-23.95%
IRadimed Corporation (IRMD)vs ›	$1.08B	20.18%	20.20%	19.35%	14.75%
First Tracks Biotherapeutics Inc (TRAX)vs ›	$1.10B	-59.76%	-52.20%	-44.07%	-44.07%
STAAR Surgical Company (STAA)vs ›	$1.10B	4.80%	-11.69%	-3.45%	0.45%
Tandem Diabetes Care, Inc. (TNDM)vs ›	$1.11B	-4.77%	-12.63%	-16.63%	-10.82%
Replimune Group, Inc. (REPL)vs ›	$1.11B	-139.11%	-85.10%	-62.90%	-49.14%
Avalyn Pharma Inc. Common Stock (AVLN)vs ›	$1.13B	-67.73%	-67.73%	-67.73%	-67.73%
Teladoc Health, Inc. (TDOC)vs ›	$1.05B	-7.32%	-21.18%	-91.27%	-61.58%
Harrow Health, Inc. (HROW)vs ›	$1.13B	1.81%	7.83%	4.30%	3.30%

NAME

MARKET CAP

RETURN ON INVESTED CAPITAL (ROIC)

TTM

OPKO Health, Inc. (OPK)

$1.09B

-8.86%

-10.49%

-9.79%

-9.38%

Bicara Therapeutics Inc. Common Stock (BCAX)vs ›

$1.09B

-42.98%

-26.82%

-23.95%

IRadimed Corporation (IRMD)vs ›

$1.08B

20.18%

20.20%

19.35%

14.75%

First Tracks Biotherapeutics Inc (TRAX)vs ›

$1.10B

-59.76%

-52.20%

-44.07%

STAAR Surgical Company (STAA)vs ›

$1.10B

4.80%

-11.69%

-3.45%

0.45%

Tandem Diabetes Care, Inc. (TNDM)vs ›

$1.11B

-4.77%

-12.63%

-16.63%

-10.82%

Replimune Group, Inc. (REPL)vs ›

$1.11B

-139.11%

-85.10%

-62.90%

-49.14%

Avalyn Pharma Inc. Common Stock (AVLN)vs ›

$1.13B

-67.73%

Teladoc Health, Inc. (TDOC)vs ›

$1.05B

-7.32%

-21.18%

-91.27%

-61.58%

Harrow Health, Inc. (HROW)vs ›

$1.13B

1.81%

7.83%

4.30%

3.30%

Return on Invested Capital (ROIC) Formula & Definition

ROIC = NOPAT / Invested Capital, where NOPAT = Operating Income × (1 − effective tax rate) and Invested Capital = Total Assets − (Current Liabilities − Short-Term Debt)

Return on invested capital measures the after-tax operating return a company earns on the capital invested in the business. TGMCharts computes it from reported statements: trailing-twelve-month operating income after tax, over invested capital at the latest balance sheet — total assets less the non-interest-bearing current liabilities (payables, accruals, deferred revenue) that fund them; short-term debt stays in the capital base. The tax rate is the period's own effective rate (income tax ÷ pretax income), capped at 45%; when pretax income is zero or negative, or the tax line is a net benefit, no tax is deducted — the operating figure is shown untaxed rather than adjusted by an assumed rate. Not shown for banks, insurers or funds.

Return on Invested Capital (ROIC) FAQ

What is the return on invested capital (ROIC) for OPKO Health, Inc. (OPK)?

The return on invested capital (ROIC) for OPK stock is -8.86%.

Is OPKO Health, Inc.'s return on invested capital (ROIC) high or low?

The return on invested capital (ROIC) of -8.86% is in line with its 5-year average of -9.38%, around the middle of its 5-year range (-14.96%–4.75%).

What is the TTM average return on invested capital (ROIC) for OPKO Health, Inc. (OPK)?

The TTM average return on invested capital (ROIC) for OPK stock is -10.49%.

What is the 3Y average return on invested capital (ROIC) for OPKO Health, Inc. (OPK)?

The 3Y average return on invested capital (ROIC) for OPK stock is -9.79%.

What is the 5Y average return on invested capital (ROIC) for OPKO Health, Inc. (OPK)?

The 5Y average return on invested capital (ROIC) for OPK stock is -9.38%.

What is the 10Y average return on invested capital (ROIC) for OPKO Health, Inc. (OPK)?

The 10Y average return on invested capital (ROIC) for OPK stock is -7.88%.

What is the 15Y average return on invested capital (ROIC) for OPKO Health, Inc. (OPK)?

The 15Y average return on invested capital (ROIC) for OPK stock is -8.23%.

What is the 20Y average return on invested capital (ROIC) for OPKO Health, Inc. (OPK)?

The 20Y average return on invested capital (ROIC) for OPK stock is -8.92%.

DATE	RETURN ON INVESTED CAPITAL (ROIC)
2026-06-30	-8.86%
2026-03-31	-11.81%
2025-12-31	-12.11%
2025-09-30	-11.63%
2025-06-30	-8.04%
2025-03-31	-7.59%
2024-12-31	-7.52%
2024-09-30	-9.13%
2024-06-30	-14.96%
2024-03-31	-11.04%
2023-12-31	-8.54%
2023-09-30	-7.54%
2023-06-30	-8.50%
2023-03-31	-9.29%
2022-12-31	-11.29%
2022-09-30	-11.41%
2022-06-30	-4.99%
2022-03-31	-4.57%
2021-12-31	0.89%
2021-09-30	4.75%
2021-06-30	4.42%
2021-03-31	5.62%
2020-12-31	1.71%
2020-09-30	-5.05%
2020-06-30	-8.02%
2020-03-31	-11.97%
2019-12-31	-13.15%
2019-09-30	-11.94%
2019-06-30	-11.27%
2019-03-31	-8.90%
2018-12-31	-7.67%
2018-09-30	-10.67%
2018-06-30	-11.48%
2018-03-31	-12.05%
2017-12-31	-12.20%
2017-09-30	-7.11%
2017-06-30	-5.66%
2017-03-31	-3.49%
2016-12-31	-2.91%
2016-09-30	-1.20%
2016-06-30	-0.61%
2016-03-31	-2.72%
2015-12-31	-3.85%
2015-09-30	-4.49%
2015-06-30	-11.99%
2015-03-31	-12.84%
2014-12-31	-12.17%
2014-09-30	-12.12%
2014-06-30	-9.51%
2014-03-31	-8.04%
2013-12-31	-6.07%
2013-09-30	-4.03%
2013-06-30	-7.33%
2013-03-31	-5.71%
2012-12-31	-14.62%
2012-09-30	-16.30%
2012-06-30	-15.22%
2012-03-31	-12.91%
2011-12-31	-10.60%
2011-09-30	-10.94%
2011-06-30	-10.19%
2011-03-31	-9.87%
2010-12-31	-25.03%
2010-09-30	-42.28%
2010-06-30	-41.55%
2010-03-31	-31.87%
2009-12-31	-35.59%
2009-09-30	-36.53%
2009-06-30	-58.12%
2009-03-31	-382.14%
2008-12-31	-272.55%
2008-09-30	-182.37%
2008-06-30	-207.61%
2008-03-31	-126.95%
2007-12-31	-55.41%
2007-09-30	-122.13%
2007-06-30	-126.64%
2007-03-31	-6.63%
2006-12-31	-11.54%
2006-09-30	-10.48%
2006-06-30	-9.28%
2006-03-31	-12.82%
2005-12-31	-9.07%
2005-09-30	-14.62%
2005-06-30	-16.73%
2005-03-31	-17.07%
2004-12-31	-20.86%
2004-09-30	-11.11%
2004-06-30	-23.01%
2004-03-31	-35.64%
2003-12-31	-36.22%
2003-09-30	-55.45%
2003-06-30	-58.62%

DATE

RETURN ON INVESTED CAPITAL (ROIC)

2026-06-30

-8.86%

2026-03-31

-11.81%

2025-12-31

-12.11%

2025-09-30

-11.63%

2025-06-30

-8.04%

2025-03-31

-7.59%

2024-12-31

-7.52%

2024-09-30

-9.13%

2024-06-30

-14.96%

2024-03-31

-11.04%

2023-12-31

-8.54%

2023-09-30

-7.54%

2023-06-30

-8.50%

2023-03-31

-9.29%

2022-12-31

-11.29%

2022-09-30

-11.41%

2022-06-30

-4.99%

2022-03-31

-4.57%

2021-12-31

0.89%

2021-09-30

4.75%

2021-06-30

4.42%

2021-03-31

5.62%

2020-12-31

1.71%

2020-09-30

-5.05%

2020-06-30

-8.02%

2020-03-31

-11.97%

2019-12-31

-13.15%

2019-09-30

-11.94%

2019-06-30

-11.27%

2019-03-31

-8.90%

2018-12-31

-7.67%

2018-09-30

-10.67%

2018-06-30

-11.48%

2018-03-31

-12.05%

2017-12-31

-12.20%

2017-09-30

-7.11%

2017-06-30

-5.66%

2017-03-31

-3.49%

2016-12-31

-2.91%

2016-09-30

-1.20%

2016-06-30

-0.61%

2016-03-31

-2.72%

2015-12-31

-3.85%

2015-09-30

-4.49%

2015-06-30

-11.99%

2015-03-31

-12.84%

2014-12-31

-12.17%

2014-09-30

-12.12%

2014-06-30

-9.51%

2014-03-31

-8.04%

2013-12-31

-6.07%

2013-09-30

-4.03%

2013-06-30

-7.33%

2013-03-31

-5.71%

2012-12-31

-14.62%

2012-09-30

-16.30%

2012-06-30

-15.22%

2012-03-31

-12.91%

2011-12-31

-10.60%

2011-09-30

-10.94%

2011-06-30

-10.19%

2011-03-31

-9.87%

2010-12-31

-25.03%

2010-09-30

-42.28%

2010-06-30

-41.55%

2010-03-31

-31.87%

2009-12-31

-35.59%

2009-09-30

-36.53%

2009-06-30

-58.12%

2009-03-31

-382.14%

2008-12-31

-272.55%

2008-09-30

-182.37%

2008-06-30

-207.61%

2008-03-31

-126.95%

2007-12-31

-55.41%

2007-09-30

-122.13%

2007-06-30

-126.64%

2007-03-31

-6.63%

2006-12-31

-11.54%

2006-09-30

-10.48%

2006-06-30

-9.28%

2006-03-31

-12.82%

2005-12-31

-9.07%

2005-09-30

-14.62%

2005-06-30

-16.73%

2005-03-31

-17.07%

2004-12-31

-20.86%

2004-09-30

-11.11%

2004-06-30

-23.01%

2004-03-31

-35.64%

2003-12-31

-36.22%

2003-09-30

-55.45%

2003-06-30

-58.62%

Return on Invested Capital (ROIC): -8.86%

OPK Return on Invested Capital (ROIC)

OPK Average Return on Invested Capital (ROIC) Chart

OPK Current vs Average Return on Invested Capital (ROIC) Chart

OPK Return on Invested Capital (ROIC) Metrics

OPK Competitors' Return on Invested Capital (ROIC)

Capital Efficiency

Return on Invested Capital (ROIC) Formula & Definition

Return on Invested Capital (ROIC) FAQ

OPK Return on Invested Capital (ROIC) History

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