OPKO Health (OPK) Operating Margin: History & Chart

OPKO Health, Inc.(OPK)

Medical - Diagnostics & Research · Miami, FL

$1.46-0.11 (-7.01%)

Delayed quote: Oct 6, 2026, 4:00 PM EDT

About OPKO Health, Inc.

OPKO Health, Inc. operates as a healthcare enterprise with a dual focus on diagnostics and pharmaceuticals. Its operations span the United States, Ireland, Chile, Spain, Israel, Mexico, and other international markets. The company's Diagnostics division encompasses BioReference Laboratories, which delivers a comprehensive suite of laboratory testing services. These services are crucial for disease detection, diagnosis, evaluation, monitoring, and treatment, covering areas such as esoteric testing, molecular diagnostics, anatomical pathology, genetics, women's health, and correctional healthcare. BioReference serves a diverse client base, including medical practices, clinics, hospitals, employers, and government entities. Additionally, this segment provides a cutting-edge diagnostic instrument system designed for immediate, point-of-care blood test results, alongside its specialized 4Kscore testing for prostate cancer. Within the Pharmaceutical segment, OPKO offers a range of therapeutic products and a robust development pipeline. Key offerings include Rayaldee, indicated for the management of secondary hyperparathyroidism in adults suffering from stage 3 or 4 chronic kidney disease and vitamin D insufficiency. The pipeline features OPK88004, an investigational orally administered selective androgen receptor modulator; OPK88003, a peptide administered once weekly currently in Phase IIb trials for the treatment of type 2 diabetes and obesity; and hGH-CTP, a once-weekly human growth hormone injection that has successfully completed Phase III clinical trials in collaboration with Pfizer, Inc. A core strategy for this segment involves the development and commercialization of proprietary, extended-release versions of existing therapeutic proteins. Furthermore, OPKO Health supplies specialty active pharmaceutical ingredients (APIs) and is involved in the development, manufacturing, marketing, and sale of pharmaceutical, nutraceutical, veterinary, and ophthalmic products. The company also commercializes food supplements and over-the-counter products, produces and sells items primarily within the generics market, and handles the import, marketing, distribution, and sales of pharmaceutical products across various therapeutic areas, including cardiovascular conditions, vaccines, antibiotics, gastro-intestinal ailments, and hormone-related treatments, among others. Its pharmaceutical operations are further bolstered by platforms situated in Ireland, Chile, Spain, and Mexico. Founded in 1991, OPKO Health, Inc. maintains its corporate headquarters in Miami, Florida.

Miami, FL

2,275 employees

www.opko.com

Healthcare / Medical - Diagnostics & Research

Sector: Healthcare
Industry: Medical - Diagnostics & Research
CEO: Phillip Frost

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OPK Operating Margin Metrics

OPERATING MARGIN

-36.08%

OPERATING MARGIN AVG TTM

-28.94%

OPERATING MARGIN AVG 3Y

-26.59%

OPERATING MARGIN AVG 5Y

-22.26%

OPERATING MARGIN AVG 10Y

-19.32%

OPERATING MARGIN AVG 15Y

-32.07%

OPERATING MARGIN AVG 20Y

-37.42%

CURRENT VS TTM AVG

-24.68%

CURRENT VS 3Y AVG

-35.67%

CURRENT VS 5Y AVG

-62.11%

CURRENT VS 10Y AVG

-86.76%

CURRENT VS 15Y AVG

-12.52%

CURRENT VS 20Y AVG

+3.58%

SECTOR MEDIAN · HEALTHCARE

0.00%

median of 863 covered companies

CURRENT VS SECTOR MEDIAN

N/A

vs the sector median at left

NAME	MARKET CAP	OPERATING MARGIN	TTM	3Y	5Y
OPKO Health, Inc. (OPK)	$1.09B	-36.08%	-28.94%	-26.59%	-22.26%
Bicara Therapeutics Inc. Common Stock (BCAX)vs ›	$1.09B	0.00%	0.00%	0.00%	0.00%
IRadimed Corporation (IRMD)vs ›	$1.08B	31.92%	30.59%	30.27%	23.69%
First Tracks Biotherapeutics Inc (TRAX)vs ›	$1.10B	0.00%	0.00%	0.00%	0.00%
STAAR Surgical Company (STAA)vs ›	$1.10B	-19.19%	-19.19%	-4.83%	3.07%
Tandem Diabetes Care, Inc. (TNDM)vs ›	$1.11B	-4.13%	-9.12%	-15.26%	-9.90%
Replimune Group, Inc. (REPL)vs ›	$1.11B	0.00%	0.00%	0.00%	0.00%
Avalyn Pharma Inc. Common Stock (AVLN)vs ›	$1.13B	0.00%	0.00%	0.00%	0.00%
Teladoc Health, Inc. (TDOC)vs ›	$1.05B	-6.98%	-25.06%	-156.73%	-114.38%
Harrow Health, Inc. (HROW)vs ›	$1.13B	14.18%	9.30%	5.28%	4.02%

NAME

MARKET CAP

OPERATING MARGIN

TTM

OPKO Health, Inc. (OPK)

$1.09B

-36.08%

-28.94%

-26.59%

-22.26%

Bicara Therapeutics Inc. Common Stock (BCAX)vs ›

$1.09B

0.00%

IRadimed Corporation (IRMD)vs ›

$1.08B

31.92%

30.59%

30.27%

23.69%

First Tracks Biotherapeutics Inc (TRAX)vs ›

$1.10B

0.00%

STAAR Surgical Company (STAA)vs ›

$1.10B

-19.19%

-4.83%

3.07%

Tandem Diabetes Care, Inc. (TNDM)vs ›

$1.11B

-4.13%

-9.12%

-15.26%

-9.90%

Replimune Group, Inc. (REPL)vs ›

$1.11B

0.00%

Avalyn Pharma Inc. Common Stock (AVLN)vs ›

$1.13B

0.00%

Teladoc Health, Inc. (TDOC)vs ›

$1.05B

-6.98%

-25.06%

-156.73%

-114.38%

Harrow Health, Inc. (HROW)vs ›

$1.13B

14.18%

9.30%

5.28%

4.02%

Operating Margin FAQ

What is the operating margin for OPKO Health, Inc. (OPK)?

The operating margin for OPK stock is -36.08%.

Is OPKO Health, Inc.'s operating margin high or low?

The operating margin of -36.08% is 62% below its 5-year average of -22.26%, near the low end of its 5-year range (-48.86%–9.80%).

What is the TTM average operating margin for OPKO Health, Inc. (OPK)?

The TTM average operating margin for OPK stock is -28.94%.

What is the 3Y average operating margin for OPKO Health, Inc. (OPK)?

The 3Y average operating margin for OPK stock is -26.59%.

What is the 5Y average operating margin for OPKO Health, Inc. (OPK)?

The 5Y average operating margin for OPK stock is -22.26%.

What is the 10Y average operating margin for OPKO Health, Inc. (OPK)?

The 10Y average operating margin for OPK stock is -19.32%.

What is the 15Y average operating margin for OPKO Health, Inc. (OPK)?

The 15Y average operating margin for OPK stock is -32.07%.

What is the 20Y average operating margin for OPKO Health, Inc. (OPK)?

The 20Y average operating margin for OPK stock is -37.42%.

DATE	OPERATING MARGIN
2026-06-30	-4.26%
2026-03-31	-41.08%
2025-12-31	-25.81%
2025-09-30	-35.29%
2025-06-30	-38.25%
2025-03-31	-44.79%
2024-12-31	-18.05%
2024-09-30	8.19%
2024-06-30	-33.85%
2024-03-31	-41.15%
2023-12-31	-37.96%
2023-09-30	-36.06%
2023-06-30	2.65%
2023-03-31	-12.88%
2022-12-31	-29.82%
2022-09-30	-48.86%
2022-06-30	-3.47%
2022-03-31	-22.00%
2021-12-31	-15.72%
2021-09-30	9.80%
2021-06-30	1.26%
2021-03-31	7.05%
2020-12-31	9.97%
2020-09-30	5.13%
2020-06-30	9.02%
2020-03-31	-19.28%
2019-12-31	-50.13%
2019-09-30	-17.05%
2019-06-30	-20.88%
2019-03-31	-33.85%
2018-12-31	-40.56%
2018-09-30	-13.40%
2018-06-30	-1.94%
2018-03-31	-16.72%
2017-12-31	-79.30%
2017-09-30	-22.12%
2017-06-30	-8.22%
2017-03-31	-14.09%
2016-12-31	-18.29%
2016-09-30	-7.93%
2016-06-30	7.92%
2016-03-31	-9.46%
2015-12-31	-2.86%
2015-09-30	-5.75%
2015-06-30	-59.89%
2015-03-31	-189.18%
2014-12-31	-127.26%
2014-09-30	-243.77%
2014-06-30	-148.16%
2014-03-31	-135.93%
2013-12-31	-173.33%
2013-09-30	-92.10%
2013-06-30	-75.49%
2013-03-31	-21.59%
2012-12-31	-59.73%
2012-09-30	-79.43%
2012-06-30	-91.48%
2012-03-31	-100.80%
2011-12-31	-146.27%
2011-09-30	-85.27%
2011-06-30	-56.66%
2011-03-31	-60.52%
2010-12-31	-6.42%
2010-09-30	-75.94%
2010-06-30	-74.14%
2010-03-31	-51.33%
2009-12-31	-119.13%
2009-09-30	-390.01%
2009-06-30	-223.56%
2009-03-31	-372.97%
2008-12-31	-550.15%
2008-09-30	-197.06%
2008-06-30	-1213.77%
2008-03-31	-376.49%
2007-12-31	-1055.14%
2007-09-30	0.00%
2007-06-30	0.00%
2007-03-31	-5.71%
2006-12-31	0.00%
2006-09-30	0.00%
2006-06-30	0.00%
2006-03-31	0.00%
2005-12-31	0.00%
2005-09-30	0.00%
2005-06-30	0.00%
2005-03-31	-2206.67%
2004-12-31	0.00%
2004-09-30	0.00%
2004-06-30	0.00%
2004-03-31	0.00%
2003-12-31	0.00%
2003-09-30	0.00%
2003-06-30	0.00%
2003-03-31	-8169.23%
2002-12-31	-35800.00%
2002-09-30	0.00%

DATE

OPERATING MARGIN

2026-06-30

-4.26%

2026-03-31

-41.08%

2025-12-31

-25.81%

2025-09-30

-35.29%

2025-06-30

-38.25%

2025-03-31

-44.79%

2024-12-31

-18.05%

2024-09-30

8.19%

2024-06-30

-33.85%

2024-03-31

-41.15%

2023-12-31

-37.96%

2023-09-30

-36.06%

2023-06-30

2.65%

2023-03-31

-12.88%

2022-12-31

-29.82%

2022-09-30

-48.86%

2022-06-30

-3.47%

2022-03-31

-22.00%

2021-12-31

-15.72%

2021-09-30

9.80%

2021-06-30

1.26%

2021-03-31

7.05%

2020-12-31

9.97%

2020-09-30

5.13%

2020-06-30

9.02%

2020-03-31

-19.28%

2019-12-31

-50.13%

2019-09-30

-17.05%

2019-06-30

-20.88%

2019-03-31

-33.85%

2018-12-31

-40.56%

2018-09-30

-13.40%

2018-06-30

-1.94%

2018-03-31

-16.72%

2017-12-31

-79.30%

2017-09-30

-22.12%

2017-06-30

-8.22%

2017-03-31

-14.09%

2016-12-31

-18.29%

2016-09-30

-7.93%

2016-06-30

7.92%

2016-03-31

-9.46%

2015-12-31

-2.86%

2015-09-30

-5.75%

2015-06-30

-59.89%

2015-03-31

-189.18%

2014-12-31

-127.26%

2014-09-30

-243.77%

2014-06-30

-148.16%

2014-03-31

-135.93%

2013-12-31

-173.33%

2013-09-30

-92.10%

2013-06-30

-75.49%

2013-03-31

-21.59%

2012-12-31

-59.73%

2012-09-30

-79.43%

2012-06-30

-91.48%

2012-03-31

-100.80%

2011-12-31

-146.27%

2011-09-30

-85.27%

2011-06-30

-56.66%

2011-03-31

-60.52%

2010-12-31

-6.42%

2010-09-30

-75.94%

2010-06-30

-74.14%

2010-03-31

-51.33%

2009-12-31

-119.13%

2009-09-30

-390.01%

2009-06-30

-223.56%

2009-03-31

-372.97%

2008-12-31

-550.15%

2008-09-30

-197.06%

2008-06-30

-1213.77%

2008-03-31

-376.49%

2007-12-31

-1055.14%

2007-09-30

0.00%

2007-06-30

0.00%

2007-03-31

-5.71%

2006-12-31

0.00%

2006-09-30

0.00%

2006-06-30

0.00%

2006-03-31

0.00%

2005-12-31

0.00%

2005-09-30

0.00%

2005-06-30

0.00%

2005-03-31

-2206.67%

2004-12-31

0.00%

2004-09-30

0.00%

2004-06-30

0.00%

2004-03-31

0.00%

2003-12-31

0.00%

2003-09-30

0.00%

2003-06-30

0.00%

2003-03-31

-8169.23%

2002-12-31

-35800.00%

2002-09-30

0.00%

Operating Margin: -36.08%

OPK Operating Margin

OPK Average Operating Margin Chart

OPK Current vs Average Operating Margin Chart

OPK Operating Margin Metrics

OPK Competitors' Operating Margin

Operating Efficiency

Operating Margin Formula & Definition

Operating Margin FAQ

OPK Operating Margin History

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