Avalyn Pharma Inc. Common Stock (AVLN) vs OPKO Health, Inc. (OPK)

A side-by-side comparison of Avalyn Pharma Inc. Common Stock and OPKO Health, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

AVLN

Avalyn Pharma Inc. Common Stock

$1.13B

$25.43HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

OPK

OPKO Health, Inc.

$1.09B

$1.46HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — AVLN vs OPK

growth of $100 · dividends reinvested · last 1y

AVLN -8.3% (-8.3%/yr)OPK +28.7% (+28.7%/yr)OPK compounded faster over this window

AVLN OPK

AVLN vs OPK: by the numbers

•AVLN is the larger company ($1.13B vs $1.09B market cap).
•Both run net losses; AVLN's is the smaller (0.00% vs -12.40% net margin).

Metrics side by side

Valuation

Metric	AVLN	OPK
P/S ratio	N/A	1.85
P/B ratio	2.83	0.92

Profitability

Metric	AVLN	OPK
Gross margin	0.00%	21.10%
Operating margin	0.00%	-36.08%
Net margin	0.00%	-12.40%
ROE	N/A	-6.16%
ROIC	-67.73%	-8.86%

Growth (annualized)

Metric	AVLN	OPK
Revenue CAGR (5Y)	N/A	-21.00%
Total return CAGR (5Y)	N/A	-15.39%

Go deeper

Full AVLN analysis Full OPK analysis Interactive comparison tool

Dig into the metrics

Avalyn Pharma Inc. Common Stock ROE OPKO Health ROE Avalyn Pharma Inc. Common Stock operating margin OPKO Health operating margin Avalyn Pharma Inc. Common Stock revenue growth OPKO Health revenue growth Avalyn Pharma Inc. Common Stock free cash flow OPKO Health free cash flow

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.