OPKO Health, Inc. (OPK) vs Replimune Group, Inc. (REPL)
A side-by-side comparison of OPKO Health, Inc. and Replimune Group, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
OPK
OPKO Health, Inc.
$1.48HealthcareDelayed quote: Oct 6, 2026, 1:49 PM EDT
REPL
Replimune Group, Inc.
$13.23HealthcareDelayed quote: Oct 6, 2026, 1:50 PM EDT
Total return — OPK vs REPL
growth of $100 · dividends reinvested · last 8yOPK -75.0% (-15.9%/yr)REPL -13.3% (-1.8%/yr)REPL compounded faster over this window
OPK REPL
OPK vs REPL: by the numbers
- •REPL is the larger company ($1.11B vs $1.10B market cap).
- •Both run net losses; REPL's is the smaller (0.00% vs -12.40% net margin).
Metrics side by side
Valuation
| Metric | OPK | REPL |
|---|---|---|
| P/S ratio | 1.88 | N/A |
| P/B ratio | 0.93 | 10.52 |
Profitability
| Metric | OPK | REPL |
|---|---|---|
| Gross margin | 21.10% | 0.00% |
| Operating margin | -36.08% | 0.00% |
| Net margin | -12.40% | 0.00% |
| ROE | -6.16% | -281.14% |
| ROIC | -8.86% | -139.11% |
Growth (annualized)
| Metric | OPK | REPL |
|---|---|---|
| Revenue CAGR (5Y) | -21.00% | N/A |
| Total return CAGR (5Y) | -15.39% | -15.17% |
Frequently asked
- How have OPK and REPL total returns compared?
- Over the past 5 years, OPK delivered -15.39% and REPL delivered -15.17% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.