Basis: Trailing twelve months (TTM net income over TTM revenue). Source: stored company filings and market data; unavailable inputs remain N/A.
Is the net profit margin high or low?
The net profit margin of -139.18% is 46% below its 5-year average of -95.36%, near the low end of its 5-year range (-942.16%–1833.84%).
29.20% below its 12-month average of -107.72%.
Reported quarterly profit margin; no daily interpolation. Q2 FY2026 (2026-06-30): -38.14%.
NET PROFIT MARGIN
-139.18%
NET PROFIT MARGIN AVG TTM
-107.72%
NET PROFIT MARGIN AVG 3Y
-24.19%
NET PROFIT MARGIN AVG 5Y
-95.36%
NET PROFIT MARGIN AVG 10Y
N/A
NET PROFIT MARGIN AVG 15Y
N/A
NET PROFIT MARGIN AVG 20Y
N/A
CURRENT VS TTM AVG
-29.20%
CURRENT VS 3Y AVG
-475.39%
CURRENT VS 5Y AVG
-45.95%
CURRENT VS 10Y AVG
N/A
CURRENT VS 15Y AVG
N/A
CURRENT VS 20Y AVG
N/A
SECTOR MEDIAN · HEALTHCARE
-0.35%
median of 862 covered companies
CURRENT VS SECTOR MEDIAN
-39665.71%
vs the sector median at left
Mirum Pharmaceuticals, Inc.
Market Cap
$4.83B
Net Profit Margin
-139.18%
TTM Avg
-107.72%
3Y Avg
-24.19%
5Y Avg
-95.36%
Market Cap
$4.84B
Net Profit Margin
0.00%
TTM Avg
0.00%
3Y Avg
0.00%
5Y Avg
0.00%
Market Cap
$4.78B
Net Profit Margin
-1570.85%
TTM Avg
-4668.05%
3Y Avg
-2830.27%
5Y Avg
-2034.87%
Market Cap
$4.73B
Net Profit Margin
0.00%
TTM Avg
0.00%
3Y Avg
0.00%
5Y Avg
0.00%
Market Cap
$4.70B
Net Profit Margin
3.19%
TTM Avg
-1.95%
3Y Avg
-11.66%
5Y Avg
-17.12%
Market Cap
$4.64B
Net Profit Margin
3.68%
TTM Avg
3.96%
3Y Avg
4.48%
5Y Avg
3.62%
Market Cap
$5.06B
Net Profit Margin
11.18%
TTM Avg
4.08%
3Y Avg
-1.40%
5Y Avg
-2.75%
Market Cap
$4.60B
Net Profit Margin
8.43%
TTM Avg
-12.40%
3Y Avg
-46.69%
5Y Avg
-46.69%
| NAME | MARKET CAP | NET PROFIT MARGIN | TTM | 3Y | 5Y |
|---|---|---|---|---|---|
| Mirum Pharmaceuticals, Inc. (MIRM) | $4.83B | -139.18% | -107.72% | -24.19% | -95.36% |
| Oruka Therapeutics, Inc. (ORKA)vs › | $4.84B | 0.00% | 0.00% | 0.00% | 0.00% |
| Dianthus Therapeutics, Inc. (DNTH)vs › | $4.78B | -1570.85% | -4668.05% | -2830.27% | -2034.87% |
| Definium Therapeutics, Inc. (DFTX)vs › | $4.73B | 0.00% | 0.00% | 0.00% | 0.00% |
| Erasca, Inc. (ERAS)vs › | $4.96B | 0.00% | 0.00% | 0.00% | 0.00% |
| LifeStance Health Group, Inc. (LFST)vs › | $4.70B | 3.19% | -1.95% | -11.66% | -17.12% |
| Option Care Health, Inc. (OPCH)vs › | $4.64B | 3.68% | 3.96% | 4.48% | 3.62% |
| Waystar Holding Corp. (WAY)vs › | $5.06B | 11.18% | 4.08% | -1.40% | -2.75% |
| BillionToOne, Inc. (BLLN)vs › | $4.60B | 8.43% | -12.40% | -46.69% | -46.69% |
| Merit Medical Systems, Inc. (MMSI)vs › | $5.07B | 9.22% | 8.68% | 7.83% | 5.80% |
Operating Margin
-4.3%
Net Profit Margin
-139.2%
Net Profit Margin = Net Income / Revenue
Net profit margin is the percentage of revenue that becomes net income after all expenses, taxes, and interest.
Expanded definitions: Investopedia, Wikipedia, Corporate Finance Institute
| DATE | NET PROFIT MARGIN |
|---|---|
| 2026-06-30 | -38.14% |
| 2026-03-31 | -494.21% |
| 2025-12-31 | -3.85% |
| 2025-09-30 | 2.18% |
| 2025-06-30 | -4.59% |
| 2025-03-31 | -13.15% |
| 2024-12-31 | -23.93% |
| 2024-09-30 | -15.75% |
| 2024-06-30 | -31.64% |
| 2024-03-31 | -36.52% |
| 2023-12-31 | -51.27% |
| 2023-09-30 | -49.42% |
| 2023-06-30 | -197.45% |
| 2023-03-31 | -95.35% |
| 2022-12-31 | -130.55% |
| 2022-09-30 | -190.13% |
| 2022-06-30 | -153.98% |
| 2022-03-31 | -283.94% |
| 2021-12-31 | 1833.84% |
| 2021-09-30 | -942.16% |
| 2021-06-30 | -399.04% |
| 2021-03-31 | 0.00% |
| 2020-12-31 | 0.00% |
| 2020-09-30 | 0.00% |
| 2020-06-30 | 0.00% |
| 2020-03-31 | 0.00% |
| 2019-12-31 | 0.00% |
| 2019-09-30 | 0.00% |
| 2019-06-30 | 0.00% |
| 2019-03-31 | 0.00% |
| 2018-12-31 | 0.00% |
| 2018-09-30 | 0.00% |
