How have MIRM and ORKA total returns compared?

Over the past 5 years, MIRM delivered 37.24% and ORKA delivered 32.76% annualized total return. Past performance doesn't predict future results.

Mirum Pharmaceuticals, Inc. (MIRM) vs Oruka Therapeutics, Inc. (ORKA)

A side-by-side comparison of Mirum Pharmaceuticals, Inc. and Oruka Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

MIRM

Mirum Pharmaceuticals, Inc.

$4.83B

$79.25HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

ORKA

Oruka Therapeutics, Inc.

$4.84B

$80.18HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — MIRM vs ORKA

growth of $100 · dividends reinvested · last 7y

MIRM +516.4% (+29.7%/yr)ORKA +67.2% (+7.6%/yr)MIRM compounded faster over this window

MIRM ORKA

MIRM vs ORKA: by the numbers

•ORKA is the larger company ($4.84B vs $4.83B market cap).
•Both run net losses; ORKA's is the smaller (0.00% vs -139.18% net margin).

Metrics side by side

Valuation

Metric	MIRM	ORKA
P/S ratio	7.82	N/A
P/B ratio	N/A	4.35

Profitability

Metric	MIRM	ORKA
Gross margin	81.70%	0.00%
Operating margin	-4.25%	0.00%
Net margin	-139.18%	0.00%
ROE	N/A	-11.92%
ROIC	-13.09%	-13.88%

Growth (annualized)

Metric	MIRM	ORKA
Revenue CAGR (5Y)	123.86%	N/A
Total return CAGR (5Y)	37.24%	32.76%

Frequently asked

How have MIRM and ORKA total returns compared?: Over the past 5 years, MIRM delivered 37.24% and ORKA delivered 32.76% annualized total return. Past performance doesn't predict future results.

Go deeper

Full MIRM analysis Full ORKA analysis Interactive comparison tool

Dig into the metrics

Mirum Pharmaceuticals ROE Oruka Therapeutics ROE Mirum Pharmaceuticals operating margin Oruka Therapeutics operating margin Mirum Pharmaceuticals revenue growth Oruka Therapeutics revenue growth Mirum Pharmaceuticals free cash flow Oruka Therapeutics free cash flow

Mirum Pharmaceuticals & Oruka Therapeutics appear in these rankings

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Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.