Which has grown faster, IONS or TGTX?

Over the past five years, TGTX grew revenue faster — IONS at a 4.91% CAGR versus TGTX at 219.22%.

Is IONS or TGTX more profitable?

TGTX runs the higher net margin — IONS at -64.64% versus TGTX at 55.22%.

How have IONS and TGTX total returns compared?

Over the past 10 years, IONS delivered 1.80% and TGTX delivered 20.46% annualized total return. Past performance doesn't predict future results.

Ionis Pharmaceuticals, Inc. (IONS) vs TG Therapeutics, Inc. (TGTX)

A side-by-side comparison of Ionis Pharmaceuticals, Inc. and TG Therapeutics, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

IONS

Ionis Pharmaceuticals, Inc.

$7.31B

$44.00HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

TGTX

TG Therapeutics, Inc.

$7.99B

$52.19HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — IONS vs TGTX

growth of $100 · dividends reinvested · last 10y

IONS +22.0% (+2.0%/yr)TGTX +540.3% (+20.4%/yr)TGTX compounded faster over this window

Log scale — wide-divergence pair

IONS TGTX

IONS vs TGTX: by the numbers

•TGTX is the larger company ($7.99B vs $7.31B market cap).
•TGTX is profitable (55.22% net margin) while IONS runs a net loss (-64.64%).
•TGTX grew revenue faster over the past five years (219.22% vs 4.91% CAGR).

Metrics side by side

Valuation

Metric	IONS	TGTX
P/E ratio	N/A	19.05
Forward P/E	N/A	53.62
P/S ratio	8.37	9.99
P/B ratio	16.63	13.23
EV / EBITDA	2.21	60.46
FCF yield	N/A	0.22%

Profitability

Metric	IONS	TGTX
Gross margin	98.16%	82.36%
Operating margin	-40.47%	17.05%
Net margin	-64.64%	55.22%
ROE	-128.44%	73.08%
ROIC	-20.37%	9.94%

Growth (annualized)

Metric	IONS	TGTX
Revenue CAGR (5Y)	4.91%	219.22%
Total return CAGR (5Y)	5.82%	10.75%

Frequently asked

Which has grown faster, IONS or TGTX?: Over the past five years, TGTX grew revenue faster — IONS at a 4.91% CAGR versus TGTX at 219.22%.
Is IONS or TGTX more profitable?: TGTX runs the higher net margin — IONS at -64.64% versus TGTX at 55.22%.
How have IONS and TGTX total returns compared?: Over the past 10 years, IONS delivered 1.80% and TGTX delivered 20.46% annualized total return. Past performance doesn't predict future results.

Go deeper

Full IONS analysis Full TGTX analysis Interactive comparison tool

Dig into the metrics

TG Therapeutics P/E ratio Ionis Pharmaceuticals ROE TG Therapeutics ROE Ionis Pharmaceuticals operating margin TG Therapeutics operating margin Ionis Pharmaceuticals revenue growth TG Therapeutics revenue growth Ionis Pharmaceuticals free cash flow TG Therapeutics free cash flow

Ionis Pharmaceuticals & TG Therapeutics appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.