Ionis Pharmaceuticals, Inc. (IONS) vs Praxis Precision Medicines, Inc. (PRAX)
A side-by-side comparison of Ionis Pharmaceuticals, Inc. and Praxis Precision Medicines, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
IONS
Ionis Pharmaceuticals, Inc.
$44.20HealthcareDelayed quote: Oct 6, 2026, 1:00 PM EDT
PRAX
Praxis Precision Medicines, Inc.
$275.70HealthcareDelayed quote: Oct 6, 2026, 1:00 PM EDT
Total return — IONS vs PRAX
growth of $100 · dividends reinvested · last 6yIONS -7.7% (-1.3%/yr)PRAX -32.0% (-6.2%/yr)IONS compounded faster over this window
IONS PRAX
IONS vs PRAX: by the numbers
- •PRAX is the larger company ($7.69B vs $7.35B market cap).
- •Both run net losses; PRAX's is the smaller (0.00% vs -64.64% net margin).
Metrics side by side
Valuation
| Metric | IONS | PRAX |
|---|---|---|
| P/S ratio | 8.41 | N/A |
| P/B ratio | 16.70 | 5.73 |
| EV / EBITDA | 2.22 | N/A |
Profitability
| Metric | IONS | PRAX |
|---|---|---|
| Gross margin | 98.16% | 0.00% |
| Operating margin | -40.47% | 0.00% |
| Net margin | -64.64% | 0.00% |
| ROE | -128.44% | -25.29% |
| ROIC | -20.37% | -28.18% |
Growth (annualized)
| Metric | IONS | PRAX |
|---|---|---|
| Revenue CAGR (5Y) | 4.91% | N/A |
| Total return CAGR (5Y) | 5.82% | -0.21% |
Frequently asked
- How have IONS and PRAX total returns compared?
- Over the past 5 years, IONS delivered 5.82% and PRAX delivered -0.21% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.