Caris Life Sciences, Inc. (CAI) vs Ionis Pharmaceuticals, Inc. (IONS)
A side-by-side comparison of Caris Life Sciences, Inc. and Ionis Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
CAI
Caris Life Sciences, Inc.
$28.26HealthcareDelayed quote: Oct 6, 2026, 11:31 AM EDT
IONS
Ionis Pharmaceuticals, Inc.
$44.52HealthcareDelayed quote: Oct 6, 2026, 11:25 AM EDT
Total return — CAI vs IONS
growth of $100 · dividends reinvested · last 1yCAI +8.5% (+8.5%/yr)IONS +22.1% (+22.1%/yr)IONS compounded faster over this window
CAI IONS
CAI vs IONS: by the numbers
- •CAI is the larger company ($7.99B vs $7.40B market cap).
- •CAI is profitable (10.62% net margin) while IONS runs a net loss (-64.64%).
- •CAI grew revenue faster over the past five years (26.15% vs 4.91% CAGR).
Metrics side by side
Valuation
| Metric | CAI | IONS |
|---|---|---|
| P/E ratio | 78.96 | N/A |
| Forward P/E | 243.56 | N/A |
| P/S ratio | 8.07 | 8.47 |
| P/B ratio | 13.50 | 16.83 |
| EV / EBITDA | 44.53 | 2.23 |
| FCF yield | 1.83% | N/A |
Profitability
| Metric | CAI | IONS |
|---|---|---|
| Gross margin | 69.66% | 98.16% |
| Operating margin | 5.56% | -40.47% |
| Net margin | 10.62% | -64.64% |
| ROE | 17.77% | -128.44% |
| ROIC | 14.76% | -20.37% |
Growth (annualized)
| Metric | CAI | IONS |
|---|---|---|
| Revenue CAGR (5Y) | 26.15% | 4.91% |
| Total return CAGR (5Y) | N/A | 5.82% |
Frequently asked
- Which has grown faster, CAI or IONS?
- Over the past five years, CAI grew revenue faster — CAI at a 26.15% CAGR versus IONS at 4.91%.
- Is CAI or IONS more profitable?
- CAI runs the higher net margin — CAI at 10.62% versus IONS at -64.64%.
Go deeper
Dig into the metrics
Caris Life Sciences P/E ratioCaris Life Sciences ROEIonis Pharmaceuticals ROECaris Life Sciences operating marginIonis Pharmaceuticals operating marginCaris Life Sciences revenue growthIonis Pharmaceuticals revenue growthCaris Life Sciences free cash flowIonis Pharmaceuticals free cash flow
Caris Life Sciences & Ionis Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.