Booking Holdings Inc. (BKNG) vs Vertex Pharmaceuticals Incorporated (VRTX)
BKNG leads on 11 of 15 compared metrics.
A side-by-side comparison of Booking Holdings Inc. and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 13, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).
BKNG
Booking Holdings Inc.
$164.94Consumer Cyclical
VRTX
Vertex Pharmaceuticals Incorporated
$444.93Healthcare
Total return — BKNG vs VRTX
growth of $100 · last 27yBKNG +896.0%VRTX +3477.3%VRTX compounded faster
BKNG VRTX
BKNG vs VRTX: by the numbers
- •BKNG is the larger company ($127.81B vs $112.92B market cap).
- •BKNG trades at the lower earnings multiple (21.75 vs 26.39 P/E).
- •VRTX converts more revenue to profit (35.40% vs 22.23% net margin).
- •BKNG grew revenue faster over the past five years (37.43% vs 13.82% CAGR).
- •BKNG pays a dividend (0.97% yield) while VRTX does not currently pay one.
Which is better, BKNG or VRTX?
Metric tally: BKNG 11 · VRTX 4It depends on what you're optimizing for:
ValueBKNG(lower P/E)
GrowthBKNG(faster 5Y revenue CAGR)
QualityBKNG(higher ROIC)
Valuation
| Metric | BKNG | VRTX |
|---|---|---|
| P/E ratio | 21.75● | 26.39 |
| Forward P/E | 13.38● | 20.58 |
| P/S ratio | 4.73● | 9.31 |
| P/B ratio | — | 5.89 |
| PEG ratio | 0.14● | 3.23 |
| EV / EBITDA | 14.07● | 20.72 |
| FCF yield | 6.90%● | 3.25% |
Profitability
| Metric | BKNG | VRTX |
|---|---|---|
| Gross margin | 100.00%● | 86.28% |
| Operating margin | 34.28% | 38.97%● |
| Net margin | 22.23% | 35.40%● |
| ROE | -96.88% | 22.41%● |
| ROIC | 50.82%● | 18.12% |
Dividends
| Metric | BKNG | VRTX |
|---|---|---|
| Dividend yield | 0.97% | — |
| Payout ratio | 24.14% | — |
Growth (annualized)
| Metric | BKNG | VRTX |
|---|---|---|
| Revenue CAGR (5Y) | 37.43%● | 13.82% |
| EPS CAGR (5Y) | 158.62%● | 8.17% |
| FCF CAGR (5Y) | 39.83%● | 4.01% |
| Total return CAGR (5Y) | 12.81% | 18.17%● |
Frequently asked
- Which is better, BKNG or VRTX?
- It depends on your goal. value: BKNG (lower P/E); growth: BKNG (faster 5Y revenue CAGR); quality: BKNG (higher ROIC). Across all compared metrics, BKNG leads 11 to 4.
- Is BKNG or VRTX cheaper?
- On trailing earnings, BKNG is cheaper: BKNG trades at a 21.75 P/E and VRTX at 26.39.
- Which has grown faster, BKNG or VRTX?
- Over the past five years, BKNG grew revenue faster — BKNG at a 37.43% CAGR versus VRTX at 13.82%.
- Does BKNG or VRTX pay a bigger dividend?
- BKNG pays a dividend (0.97% yield) while VRTX does not currently pay one.
- Is BKNG or VRTX more profitable?
- VRTX runs the higher net margin — BKNG at 22.23% versus VRTX at 35.40%.
- Which has been the better investment, BKNG or VRTX?
- Over the past 10-year, VRTX delivered the higher annualized total return — BKNG at 12.30% versus VRTX at 17.13%. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Booking P/E ratioVertex Pharmaceuticals P/E ratioBooking dividend yieldVertex Pharmaceuticals dividend yieldBooking ROEVertex Pharmaceuticals ROEBooking operating marginVertex Pharmaceuticals operating marginBooking revenue growthVertex Pharmaceuticals revenue growthBooking free cash flowVertex Pharmaceuticals free cash flow
Booking & Vertex Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 13, 2026.