Which has grown faster, AMRX or IONS?

Over the past five years, AMRX grew revenue faster — AMRX at a 8.67% CAGR versus IONS at 4.91%.

Is AMRX or IONS more profitable?

AMRX runs the higher net margin — AMRX at 5.05% versus IONS at -64.64%.

How have AMRX and IONS total returns compared?

Over the past 10 years, AMRX delivered -1.73% and IONS delivered 1.80% annualized total return. Past performance doesn't predict future results.

Amneal Pharmaceuticals, Inc. (AMRX) vs Ionis Pharmaceuticals, Inc. (IONS)

A side-by-side comparison of Amneal Pharmaceuticals, Inc. and Ionis Pharmaceuticals, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

AMRX

Amneal Pharmaceuticals, Inc.

$6.45B

$20.21HealthcareDelayed quote: Oct 6, 2026, 10:55 AM EDT

IONS

Ionis Pharmaceuticals, Inc.

$7.30B

$43.91HealthcareDelayed quote: Oct 6, 2026, 10:55 AM EDT

Total return — AMRX vs IONS

growth of $100 · dividends reinvested · last 10y

AMRX -13.6% (-1.5%/yr)IONS +22.0% (+2.0%/yr)IONS compounded faster over this window

AMRX IONS

AMRX vs IONS: by the numbers

•IONS is the larger company ($7.30B vs $6.45B market cap).
•AMRX is profitable (5.05% net margin) while IONS runs a net loss (-64.64%).
•AMRX grew revenue faster over the past five years (8.67% vs 4.91% CAGR).

Metrics side by side

Valuation

Metric	AMRX	IONS
P/E ratio	41.46	N/A
Forward P/E	19.74	N/A
P/S ratio	2.07	8.35
P/B ratio	195.42	16.59
EV / EBITDA	15.26	2.21
FCF yield	1.29%	N/A

Profitability

Metric	AMRX	IONS
Gross margin	39.32%	98.16%
Operating margin	12.93%	-40.47%
Net margin	5.05%	-64.64%
ROE	476.51%	-128.44%
ROIC	13.45%	-20.37%

Growth (annualized)

Metric	AMRX	IONS
Revenue CAGR (5Y)	8.67%	4.91%
EPS CAGR (5Y)	-17.72%	N/A
FCF CAGR (5Y)	-14.46%	N/A
Total return CAGR (5Y)	30.25%	5.82%

Frequently asked

Which has grown faster, AMRX or IONS?: Over the past five years, AMRX grew revenue faster — AMRX at a 8.67% CAGR versus IONS at 4.91%.
Is AMRX or IONS more profitable?: AMRX runs the higher net margin — AMRX at 5.05% versus IONS at -64.64%.
How have AMRX and IONS total returns compared?: Over the past 10 years, AMRX delivered -1.73% and IONS delivered 1.80% annualized total return. Past performance doesn't predict future results.

Go deeper

Full AMRX analysis Full IONS analysis Interactive comparison tool

Dig into the metrics

Amneal Pharmaceuticals P/E ratio Amneal Pharmaceuticals ROE Ionis Pharmaceuticals ROE Amneal Pharmaceuticals operating margin Ionis Pharmaceuticals operating margin Amneal Pharmaceuticals revenue growth Ionis Pharmaceuticals revenue growth Amneal Pharmaceuticals free cash flow Ionis Pharmaceuticals free cash flow

Amneal Pharmaceuticals & Ionis Pharmaceuticals appear in these rankings

Highest ROE Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.