Which has grown faster, AGIO or ZYME?

Over the past five years, ZYME grew revenue faster — AGIO at a 4.54% CAGR versus ZYME at 12.35%.

How have AGIO and ZYME total returns compared?

Over the past 5 years, AGIO delivered -6.59% and ZYME delivered -1.37% annualized total return. Past performance doesn't predict future results.

Agios Pharmaceuticals, Inc. (AGIO) vs Zymeworks Inc. (ZYME)

A side-by-side comparison of Agios Pharmaceuticals, Inc. and Zymeworks Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

AGIO

Agios Pharmaceuticals, Inc.

$1.89B

$31.72HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

ZYME

Zymeworks Inc.

$1.89B

$25.65HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — AGIO vs ZYME

growth of $100 · dividends reinvested · last 9y

AGIO -37.1% (-5.0%/yr)ZYME +101.6% (+8.1%/yr)ZYME compounded faster over this window

AGIO ZYME

AGIO vs ZYME: by the numbers

•AGIO is the larger company ($1.89B vs $1.89B market cap).
•Both run net losses; ZYME's is the smaller (-404.00% vs -418.24% net margin).
•ZYME grew revenue faster over the past five years (12.35% vs 4.54% CAGR).

Metrics side by side

Valuation

Metric	AGIO	ZYME
Forward P/E	N/A	24.73
P/S ratio	19.26	50.83
P/B ratio	1.85	23.48

Profitability

Metric	AGIO	ZYME
Gross margin	78.67%	100.00%
Operating margin	-873.87%	-87.33%
Net margin	-418.24%	-404.00%
ROE	-40.09%	-186.63%
ROIC	-44.21%	-44.06%

Growth (annualized)

Metric	AGIO	ZYME
Revenue CAGR (5Y)	4.54%	12.35%
Total return CAGR (5Y)	-6.59%	-1.37%

Frequently asked

Which has grown faster, AGIO or ZYME?: Over the past five years, ZYME grew revenue faster — AGIO at a 4.54% CAGR versus ZYME at 12.35%.
How have AGIO and ZYME total returns compared?: Over the past 5 years, AGIO delivered -6.59% and ZYME delivered -1.37% annualized total return. Past performance doesn't predict future results.

Go deeper

Full AGIO analysis Full ZYME analysis Interactive comparison tool

Dig into the metrics

Agios Pharmaceuticals ROE Zymeworks ROE Agios Pharmaceuticals operating margin Zymeworks operating margin Agios Pharmaceuticals revenue growth Zymeworks revenue growth Agios Pharmaceuticals free cash flow Zymeworks free cash flow

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.