Spero Therapeutics (SPRO) Metrics: History & Chart

Spero Therapeutics, Inc.(SPRO)

Biotechnology · Cambridge, MA

$1.20+0.04 (+3.02%)

Delayed quote: Oct 6, 2026, 2:56 PM EDT

About Spero Therapeutics, Inc.

Spero Therapeutics, Inc. is a biopharmaceutical firm in the clinical development stage, primarily focused on discovering, advancing, and commercializing innovative treatments for multi-drug resistant (MDR) bacterial infections and rare diseases within the United States. The company's pipeline includes several key therapeutic candidates: tebipenem pivoxil hydrobromide (HBr), an oral carbapenem-class antibiotic designed to address complicated urinary tract infections (cUTIs), including pyelonephritis, in adult patients. SPR206, an intravenously administered agent specifically developed to combat MDR Gram-negative bacterial infections in hospital environments. SPR720, an oral antibiotic targeting non-tuberculous mycobacterial (NTM) pulmonary disease. Spero Therapeutics has also forged several strategic alliances: A licensing agreement with Meiji Seika Pharma Co., Ltd. supports the ongoing development of tebipenem HBr. A separate licensing deal with Everest Medicines grants rights for the development, manufacturing, and commercialization of SPR206 across Greater China, South Korea, and various Southeast Asian nations. The company collaborates with the Bill & Melinda Gates Medical Research Institute to advance SPR720 for treating lung infections caused by Mycobacterium tuberculosis. Furthermore, a licensing agreement with Vertex Pharmaceuticals Incorporated covers patents associated with SPR720 and its active metabolite, SPR719. Founded in 2013, Spero Therapeutics maintains its corporate headquarters in Cambridge, Massachusetts.

Cambridge, MA

25 employees

sperotherapeutics.com

Healthcare / Biotechnology

Sector: Healthcare
Industry: Biotechnology
CEO: Esther Rajavelu

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Third-Party DCF Estimate (FMP)	N/A
Price Gap vs Third-Party Estimate	N/A

7D Total Return	-2.52%
30D Total Return	-4.13%
YTD Total Return	-50.21%
1Y Total Return	-43.41%
3Y Total Return	0.00%
5Y Total Return	-93.82%
10Y Total Return	N/A
15Y Total Return	N/A
20Y Total Return	N/A

2026	-50.21%
2025	+126.21%
2024	-29.93%
2023	-15.03%
2022	-89.19%
2021	-17.43%
2020

CAGR TTM	-43.26%
CAGR 3Y	0.00%
CAGR 5Y	-42.70%
CAGR 10Y	N/A
CAGR 15Y	N/A
CAGR 20Y	N/A

PE Ratio	10.55
PE Ratio Avg TTM	10.78
PE Ratio Avg 3Y	8.86
Current VS TTM Avg	-2.17%
Current VS 3Y Avg	+19.06%
Current VS 5Y Avg	+19.06%

All Metrics

SPRO Valuation Metrics

SPRO Stock Price Metrics

SPRO Dividend Metrics

SPRO Growth Rate Metrics

SPRO Discounted Cash Flow Metrics

SPRO Returns By Period

SPRO Yearly Returns

SPRO Average Annual Returns By Period (CAGR)

SPRO Revenue Metrics

SPRO PE Ratio Metrics

SPRO PS Ratio Metrics

SPRO PB Ratio Metrics

SPRO Price to Free Cash Flow Ratio Metrics

SPRO Debt to Equity Ratio Metrics

SPRO PEG Ratio Metrics

SPRO FCF Yield

SPRO Earnings Yield

SPRO EBITDA Yield

SPRO OCF Yield

SPRO EV/EBIT Ratio Metrics

SPRO EV/EBITDA Ratio Metrics

SPRO EV/Assets Ratio Metrics

SPRO EV/Sales Ratio Metrics

SPRO Current Ratio Metrics

SPRO Quick Ratio Metrics

SPRO ROIC Metrics

SPRO Return on Assets Metrics

SPRO Return on Equity Metrics

SPRO Net Profit Margin Metrics

SPRO Gross Profit Margin Metrics

SPRO Tax Rate Metrics

PS Ratio	1.57
PS Ratio Avg TTM	2.77
PS Ratio Avg 3Y	1.68
Current VS TTM Avg	-43.40%
Current VS 3Y Avg	-6.72%
Current VS 5Y Avg	-46.47%

PB Ratio	1.52
PB Ratio Avg TTM	3.39
PB Ratio Avg 3Y	2.11
Current VS TTM Avg	-55.20%
Current VS 3Y Avg	-28.10%
Current VS 5Y Avg	-26.10%

PFCF Ratio	3.43
PFCF Ratio Avg TTM	11.66
PFCF Ratio Avg 3Y	5.46
Current VS TTM Avg	-70.59%
Current VS 3Y Avg	-37.19%
Current VS 5Y Avg	-52.46%

Debt/Equity Ratio	0.05
Debt/Equity Ratio Avg TTM	0.08
Debt/Equity Ratio Avg 3Y	0.08
Current VS TTM Avg	-38.96%
Current VS 3Y Avg	-42.63%
Current VS 5Y Avg	-43.15%

PEG Ratio	N/A
PEG Ratio Avg TTM	N/A
PEG Ratio Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

FCF Yield	29.12%
FCF Yield Avg TTM	14.79%
FCF Yield Avg 3Y	25.02%
Current VS TTM Avg	+96.87%
Current VS 3Y Avg	+16.39%
Current VS 5Y Avg	+39.32%

Earnings Yield	9.48%
Earnings Yield Avg TTM	8.23%
Earnings Yield Avg 3Y	14.46%
Current VS TTM Avg	+15.16%
Current VS 3Y Avg	-34.43%
Current VS 5Y Avg	-34.43%

EBITDA Yield	N/A
EBITDA Yield Avg TTM	N/A
EBITDA Yield Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

OCF Yield	N/A
OCF Yield Avg TTM	N/A
OCF Yield Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

Ev/Ebit Ratio	3.07
Ev/Ebit Ratio Avg TTM	7.69
Ev/Ebit Ratio Avg 3Y	2.24
Current VS TTM Avg	-60.08%
Current VS 3Y Avg	+37.20%
Current VS 5Y Avg	+37.20%

Ev/Ebitda Ratio	3.07
Ev/Ebitda Ratio Avg TTM	7.69
Ev/Ebitda Ratio Avg 3Y	2.23
Current VS TTM Avg	-60.07%
Current VS 3Y Avg	+37.47%
Current VS 5Y Avg	+37.47%

Ev/Assets Ratio	0.35
Ev/Assets Ratio Avg TTM	1.41
Ev/Assets Ratio Avg 3Y	0.96
Current VS TTM Avg	-75.12%
Current VS 3Y Avg	-63.53%
Current VS 5Y Avg	-61.76%

Ev/Sales Ratio	0.43
Ev/Sales Ratio Avg TTM	1.76
Ev/Sales Ratio Avg 3Y	1.34
Current VS TTM Avg	-75.57%
Current VS 3Y Avg	-67.80%
Current VS 5Y Avg	-79.56%

Current Ratio	6.12
Current Ratio Avg TTM	6.40
Current Ratio Avg 3Y	3.97
Current VS TTM Avg	-4.40%
Current VS 3Y Avg	+54.23%
Current VS 5Y Avg	+35.57%

Quick Ratio	6.12
Quick Ratio Avg TTM	6.40
Quick Ratio Avg 3Y	3.97
Current VS TTM Avg	-4.40%
Current VS 3Y Avg	+54.23%
Current VS 5Y Avg	+35.26%

ROIC	13.12%
ROIC Avg 3Y	(32.44%)
ROIC Avg 5Y	(55.11%)
Current VS 3Y Avg	+140.46%
Current VS 5Y Avg	+123.82%
Current VS 10Y Avg	+125.09%

ROA	13.99%
ROA Avg TTM	(0.19%)
ROA Avg 3Y	(11.87%)
Current VS TTM Avg	+7573.29%
Current VS 3Y Avg	+217.82%
Current VS 5Y Avg	+202.87%

ROE	16.70%
ROE Avg TTM	(53.75%)
ROE Avg 3Y	(44.03%)
Current VS TTM Avg	+131.07%
Current VS 3Y Avg	+137.93%
Current VS 5Y Avg	+120.31%

Net Profit Margin	17.18%
Net Profit Margin Avg TTM	(593.80%)
Net Profit Margin Avg 3Y	(128.12%)
Current VS TTM Avg	+102.89%
Current VS 3Y Avg	+113.41%
Current VS 5Y Avg	+105.67%

Gross Profit Margin	100.00%
Gross Pft Margin Avg TTM	80.00%
Gross Pft Margin Avg 3Y	17.99%
Current VS TTM Avg	+25.00%
Current VS 3Y Avg	+455.84%
Current VS 5Y Avg	+294.26%

Tax Rate	0.82%
Tax Rate Avg 3Y	0.52%
Tax Rate Avg 5Y	0.52%
Current VS 3Y Avg	+56.77%
Current VS 5Y Avg	+56.77%
Current VS 10Y Avg	+56.77%