Septerna (SEPN) Metrics: History & Chart

Septerna Inc(SEPN)

Biotechnology · South San Francisco, CA

$35.66-2.21 (-5.83%)

Delayed quote: Oct 6, 2026, 3:40 PM EDT

About Septerna Inc

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

South San Francisco, CA

123 employees

septerna.com

Healthcare / Biotechnology

Sector: Healthcare
Industry: Biotechnology
CEO: Jeffrey T. Finer

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Third-Party DCF Estimate (FMP)	N/A
Price Gap vs Third-Party Estimate	N/A

7D Total Return	-4.71%
30D Total Return	+3.05%
YTD Total Return	+35.83%
1Y Total Return	+83.12%
3Y Total Return	N/A
5Y Total Return	N/A
10Y Total Return	N/A
15Y Total Return	N/A
20Y Total Return	N/A

2026	+35.83%
2025	+21.75%
2024	N/A
2023	N/A
2022	N/A
2021	N/A

CAGR TTM	+82.60%
CAGR 3Y	N/A
CAGR 5Y	N/A
CAGR 10Y	N/A
CAGR 15Y	N/A
CAGR 20Y	N/A

PE Ratio	7.54
PE Ratio Avg TTM	20.76
PE Ratio Avg 3Y	20.76
Current VS TTM Avg	-63.69%
Current VS 3Y Avg	-63.69%
Current VS 5Y Avg	-63.69%

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SEPN FCF Yield

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SEPN EV/EBIT Ratio Metrics

SEPN EV/EBITDA Ratio Metrics

SEPN EV/Assets Ratio Metrics

SEPN EV/Sales Ratio Metrics

SEPN Current Ratio Metrics

SEPN Quick Ratio Metrics

SEPN ROIC Metrics

SEPN Return on Assets Metrics

SEPN Return on Equity Metrics

SEPN Net Profit Margin Metrics

SEPN Gross Profit Margin Metrics

SEPN Tax Rate Metrics

PS Ratio	17.25
PS Ratio Avg TTM	32.93
PS Ratio Avg 3Y	389.62
Current VS TTM Avg	-47.61%
Current VS 3Y Avg	-95.57%
Current VS 5Y Avg	-95.57%

PB Ratio	4.41
PB Ratio Avg TTM	3.44
PB Ratio Avg 3Y	2.87
Current VS TTM Avg	+28.14%
Current VS 3Y Avg	+53.50%
Current VS 5Y Avg	+53.50%

PFCF Ratio	16.23
PFCF Ratio Avg TTM	12.86
PFCF Ratio Avg 3Y	12.86
Current VS TTM Avg	+26.19%
Current VS 3Y Avg	+26.19%
Current VS 5Y Avg	+26.19%

Debt/Equity Ratio	0.06
Debt/Equity Ratio Avg TTM	0.06
Debt/Equity Ratio Avg 3Y	0.04
Current VS TTM Avg	-5.44%
Current VS 3Y Avg	+35.12%
Current VS 5Y Avg	+35.12%

PEG Ratio	N/A
PEG Ratio Avg TTM	N/A
PEG Ratio Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

FCF Yield	6.16%
FCF Yield Avg TTM	8.06%
FCF Yield Avg 3Y	8.06%
Current VS TTM Avg	-23.60%
Current VS 3Y Avg	-23.60%
Current VS 5Y Avg	-23.60%

Earnings Yield	13.26%
Earnings Yield Avg TTM	6.67%
Earnings Yield Avg 3Y	6.67%
Current VS TTM Avg	+98.90%
Current VS 3Y Avg	+98.90%
Current VS 5Y Avg	+98.90%

EBITDA Yield	N/A
EBITDA Yield Avg TTM	N/A
EBITDA Yield Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

OCF Yield	N/A
OCF Yield Avg TTM	N/A
OCF Yield Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

Ev/Ebit Ratio	N/A
Ev/Ebit Ratio Avg TTM	N/A
Ev/Ebit Ratio Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

Ev/Ebitda Ratio	N/A
Ev/Ebitda Ratio Avg TTM	N/A
Ev/Ebitda Ratio Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

Ev/Assets Ratio	2.90
Ev/Assets Ratio Avg TTM	2.06
Ev/Assets Ratio Avg 3Y	1.73
Current VS TTM Avg	+40.44%
Current VS 3Y Avg	+67.47%
Current VS 5Y Avg	+67.47%

Ev/Sales Ratio	16.62
Ev/Sales Ratio Avg TTM	27.45
Ev/Sales Ratio Avg 3Y	318.32
Current VS TTM Avg	-39.45%
Current VS 3Y Avg	-94.78%
Current VS 5Y Avg	-94.78%

Current Ratio	4.99
Current Ratio Avg TTM	8.61
Current Ratio Avg 3Y	11.05
Current VS TTM Avg	-41.99%
Current VS 3Y Avg	-54.79%
Current VS 5Y Avg	-54.79%

Quick Ratio	4.99
Quick Ratio Avg TTM	8.61
Quick Ratio Avg 3Y	11.05
Current VS TTM Avg	-41.99%
Current VS 3Y Avg	-54.79%
Current VS 5Y Avg	-54.79%

ROIC	(8.93%)
ROIC Avg 3Y	(14.85%)
ROIC Avg 5Y	(14.85%)
Current VS 3Y Avg	+39.85%
Current VS 5Y Avg	+39.85%
Current VS 10Y Avg	+39.85%

ROA	(4.28%)
ROA Avg TTM	(2.05%)
ROA Avg 3Y	(3.40%)
Current VS TTM Avg	-108.75%
Current VS 3Y Avg	-25.85%
Current VS 5Y Avg	-25.85%

ROE	(6.27%)
ROE Avg TTM	(13.38%)
ROE Avg 3Y	(14.82%)
Current VS TTM Avg	+53.13%
Current VS 3Y Avg	+57.70%
Current VS 5Y Avg	+57.70%

Net Profit Margin	(24.51%)
Net Profit Margin Avg TTM	(4192.01%)
Net Profit Margin Avg 3Y	(6108.86%)
Current VS TTM Avg	+99.42%
Current VS 3Y Avg	+99.60%
Current VS 5Y Avg	+99.60%

Gross Profit Margin	99.57%
Gross Pft Margin Avg TTM	99.68%
Gross Pft Margin Avg 3Y	100.00%
Current VS TTM Avg	-0.11%
Current VS 3Y Avg	-0.43%
Current VS 5Y Avg	-0.43%

Tax Rate	0.00%
Tax Rate Avg 3Y	0.97%
Tax Rate Avg 5Y	0.97%
Current VS 3Y Avg	-100.00%
Current VS 5Y Avg	-100.00%
Current VS 10Y Avg	-100.00%