Ensysce Biosciences (ENSC) Metrics: History & Chart

Ensysce Biosciences, Inc.(ENSC)

Biotechnology · La Jolla, CA

$0.42-0.00 (-0.69%)

Delayed quote: Oct 6, 2026, 11:24 AM EDT

About Ensysce Biosciences, Inc.

Ensysce Biosciences, Inc. is a clinical-stage pharmaceutical firm dedicated to developing novel prescription drugs for the treatment of severe pain in the United States, with a specific focus on preventing opioid addiction, misuse, abuse, and overdose. The company leverages two primary technological frameworks: the Trypsin Activated Abuse Protection (TAAP) platform, which creates opioid prodrugs designed to resist abuse, and the Multi-Pill Abuse Resistance (MPAR) platform, engineered to offer protection against overdose through its advanced opioid prodrug technology. Ensysce's pipeline features several key candidates, including PF614, an oxycodone prodrug developed using the TAAP platform, currently undergoing Phase II clinical trials for both acute and chronic pain management. Another product, PF614-MPAR, is a combination of PF614 and nafamostat, in Phase I clinical development to provide overdose protection against excessive oral consumption. Furthermore, the company is exploring an oral and inhaled formulation of nafamostat for potential use against coronaviral infections and other pulmonary diseases, such as cystic fibrosis. The company's development efforts also include PF329, an extended-release hydromorphone prodrug similar to PF614. In the area of ADHD treatment, Ensysce is advancing PF8001 and PF8026, which are extended-release and immediate-release amphetamine prodrugs, respectively, aimed at deterring medication abuse. Additionally, PF26810, an extended-release methadone prodrug, is in development for opioid use disorder. Ensysce Biosciences, Inc. operates from its headquarters in La Jolla, California.

La Jolla, CA

9 employees

www.ensysce.com

Healthcare / Biotechnology

Sector: Healthcare
Industry: Biotechnology
CEO: D. Lynn Kirkpatrick

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Third-Party DCF Estimate (FMP)	$0.05
Price Gap vs Third-Party Estimate	-86.88%

7D Total Return	+4.46%
30D Total Return	-8.00%
YTD Total Return	-54.45%
1Y Total Return	-83.50%
3Y Total Return	-97.46%
5Y Total Return	-100.00%
10Y Total Return	N/A
15Y Total Return	N/A
20Y Total Return	N/A

2026	-54.45%
2025	-88.70%
2024	-48.80%
2023	-88.22%
2022	-99.20%
2021	-62.20%
2020

CAGR TTM	-83.36%
CAGR 3Y	-70.60%
CAGR 5Y	-86.22%
CAGR 10Y	N/A
CAGR 15Y	N/A
CAGR 20Y	N/A

PE Ratio	2883.98
PE Ratio Avg TTM	3183.08
PE Ratio Avg 3Y	90863.20
Current VS TTM Avg	-9.40%
Current VS 3Y Avg	-96.83%
Current VS 5Y Avg	-96.92%

All Metrics

ENSC Valuation Metrics

ENSC Stock Price Metrics

ENSC Dividend Metrics

ENSC Growth Rate Metrics

ENSC Discounted Cash Flow Metrics

ENSC Returns By Period

ENSC Yearly Returns

ENSC Average Annual Returns By Period (CAGR)

ENSC Revenue Metrics

ENSC PE Ratio Metrics

ENSC PS Ratio Metrics

ENSC PB Ratio Metrics

ENSC Price to Free Cash Flow Ratio Metrics

ENSC Debt to Equity Ratio Metrics

ENSC PEG Ratio Metrics

ENSC FCF Yield

ENSC Earnings Yield

ENSC EBITDA Yield

ENSC OCF Yield

ENSC EV/EBIT Ratio Metrics

ENSC EV/EBITDA Ratio Metrics

ENSC EV/Assets Ratio Metrics

ENSC EV/Sales Ratio Metrics

ENSC Current Ratio Metrics

ENSC Quick Ratio Metrics

ENSC ROIC Metrics

ENSC Return on Assets Metrics

ENSC Return on Equity Metrics

ENSC Net Profit Margin Metrics

ENSC Gross Profit Margin Metrics

ENSC Tax Rate Metrics

PS Ratio	4.69
PS Ratio Avg TTM	4.72
PS Ratio Avg 3Y	4.72
Current VS TTM Avg	-0.55%
Current VS 3Y Avg	-0.55%
Current VS 5Y Avg	-0.55%

PB Ratio	2.23
PB Ratio Avg TTM	1.82
PB Ratio Avg 3Y	5.08
Current VS TTM Avg	+22.58%
Current VS 3Y Avg	-56.13%
Current VS 5Y Avg	-70.49%

PFCF Ratio	2290.14
PFCF Ratio Avg TTM	1251.36
PFCF Ratio Avg 3Y	1280.61
Current VS TTM Avg	+83.01%
Current VS 3Y Avg	+78.83%
Current VS 5Y Avg	+78.83%

Debt/Equity Ratio	(0.25)
Debt/Equity Ratio Avg TTM	(0.09)
Debt/Equity Ratio Avg 3Y	0.09
Current VS TTM Avg	-191.50%
Current VS 3Y Avg	-384.77%
Current VS 5Y Avg	+33.73%

PEG Ratio	N/A
PEG Ratio Avg TTM	N/A
PEG Ratio Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

FCF Yield	0.04%
FCF Yield Avg TTM	1.12%
FCF Yield Avg 3Y	0.90%
Current VS TTM Avg	-96.41%
Current VS 3Y Avg	-95.57%
Current VS 5Y Avg	-95.57%

Earnings Yield	0.03%
Earnings Yield Avg TTM	0.03%
Earnings Yield Avg 3Y	0.00%
Current VS TTM Avg	+2.31%
Current VS 3Y Avg	+2164.38%
Current VS 5Y Avg	+2205.48%

EBITDA Yield	N/A
EBITDA Yield Avg TTM	N/A
EBITDA Yield Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

OCF Yield	N/A
OCF Yield Avg TTM	N/A
OCF Yield Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

Ev/Ebit Ratio	N/A
Ev/Ebit Ratio Avg TTM	N/A
Ev/Ebit Ratio Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

Ev/Ebitda Ratio	N/A
Ev/Ebitda Ratio Avg TTM	N/A
Ev/Ebitda Ratio Avg 3Y	N/A
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

Ev/Assets Ratio	1.68
Ev/Assets Ratio Avg TTM	0.81
Ev/Assets Ratio Avg 3Y	1.62
Current VS TTM Avg	+108.27%
Current VS 3Y Avg	+3.96%
Current VS 5Y Avg	-72.91%

Ev/Sales Ratio	4.28
Ev/Sales Ratio Avg TTM	4.30
Ev/Sales Ratio Avg 3Y	4.30
Current VS TTM Avg	-0.53%
Current VS 3Y Avg	-0.53%
Current VS 5Y Avg	-0.53%

Current Ratio	0.70
Current Ratio Avg TTM	1.27
Current Ratio Avg 3Y	1.82
Current VS TTM Avg	-45.04%
Current VS 3Y Avg	-61.55%
Current VS 5Y Avg	-54.37%

Quick Ratio	0.70
Quick Ratio Avg TTM	1.27
Quick Ratio Avg 3Y	1.82
Current VS TTM Avg	-44.69%
Current VS 3Y Avg	-61.28%
Current VS 5Y Avg	-54.04%

ROIC	N/A
ROIC Avg 3Y	(394.37%)
ROIC Avg 5Y	(414.26%)
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A
Current VS 10Y Avg	N/A

ROA	(426.88%)
ROA Avg TTM	(87.30%)
ROA Avg 3Y	(62.59%)
Current VS TTM Avg	-388.98%
Current VS 3Y Avg	-582.00%
Current VS 5Y Avg	-480.22%

ROE	N/A
ROE Avg TTM	(372.31%)
ROE Avg 3Y	(423.57%)
Current VS TTM Avg	N/A
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

Net Profit Margin	(1084.23%)
Net Profit Margin Avg TTM	(44.16%)
Net Profit Margin Avg 3Y	0.00%
Current VS TTM Avg	-2355.33%
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

Gross Profit Margin	0.00%
Gross Pft Margin Avg TTM	20.00%
Gross Pft Margin Avg 3Y	0.00%
Current VS TTM Avg	-100.00%
Current VS 3Y Avg	N/A
Current VS 5Y Avg	N/A

Tax Rate	0.00%
Tax Rate Avg 3Y	N/A
Tax Rate Avg 5Y	0.71%
Current VS 3Y Avg	N/A
Current VS 5Y Avg	-100.00%
Current VS 10Y Avg	-100.00%