Stryker Corporation (SYK) vs Vertex Pharmaceuticals Incorporated (VRTX)
VRTX leads on 10 of 16 compared metrics.
A side-by-side comparison of Stryker Corporation and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 17, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).
SYK
Stryker Corporation
$310.58Healthcare
VRTX
Vertex Pharmaceuticals Incorporated
$450.46Healthcare
Total return — SYK vs VRTX
growth of $100 · last 30ySYK +4798.7%VRTX +2529.4%SYK compounded faster
SYK VRTX
SYK vs VRTX: by the numbers
- •SYK is the larger company ($119.06B vs $113.82B market cap).
- •VRTX trades at the lower earnings multiple (26.72 vs 35.95 P/E).
- •VRTX converts more revenue to profit (35.40% vs 13.21% net margin).
- •VRTX grew revenue faster over the past five years (13.82% vs 11.42% CAGR).
- •SYK pays a dividend (1.11% yield) while VRTX does not currently pay one.
Which is better, SYK or VRTX?
Metric tally: SYK 6 · VRTX 10It depends on what you're optimizing for:
ValueVRTX(lower P/E)
GrowthVRTX(faster 5Y revenue CAGR)
QualityVRTX(higher ROIC)
Metrics side by side
Valuation
| Metric | SYK | VRTX |
|---|---|---|
| P/E ratio | 35.95 | 26.72● |
| Forward P/E | 18.56● | 20.84 |
| P/S ratio | 4.75● | 9.42 |
| P/B ratio | 5.22● | 5.96 |
| PEG ratio | 5.16 | 3.27● |
| EV / EBITDA | 21.49 | 20.77● |
| FCF yield | 3.81%● | 3.21% |
Profitability
| Metric | SYK | VRTX |
|---|---|---|
| Gross margin | 63.67% | 86.28%● |
| Operating margin | 21.34% | 38.97%● |
| Net margin | 13.21% | 35.40%● |
| ROE | 14.52% | 22.41%● |
| ROIC | 8.53% | 18.12%● |
Dividends
| Metric | SYK | VRTX |
|---|---|---|
| Dividend yield | 1.11% | — |
| Payout ratio | 40.52% | — |
Growth (annualized)
| Metric | SYK | VRTX |
|---|---|---|
| Revenue CAGR (5Y) | 11.42% | 13.82%● |
| EPS CAGR (5Y) | 14.79%● | 8.17% |
| FCF CAGR (5Y) | 11.01%● | 4.01% |
| Total return CAGR (5Y) | 4.98% | 18.98%● |
Frequently asked
- Which is better, SYK or VRTX?
- It depends on your goal. value: VRTX (lower P/E); growth: VRTX (faster 5Y revenue CAGR); quality: VRTX (higher ROIC). Across all compared metrics, VRTX leads 10 to 6.
- Is SYK or VRTX cheaper?
- On trailing earnings, VRTX is cheaper: SYK trades at a 35.95 P/E and VRTX at 26.72.
- Which has grown faster, SYK or VRTX?
- Over the past five years, VRTX grew revenue faster — SYK at a 11.42% CAGR versus VRTX at 13.82%.
- Does SYK or VRTX pay a bigger dividend?
- SYK pays a dividend (1.11% yield) while VRTX does not currently pay one.
- Is SYK or VRTX more profitable?
- VRTX runs the higher net margin — SYK at 13.21% versus VRTX at 35.40%.
- Which has been the better investment, SYK or VRTX?
- Over the past 10-year, VRTX delivered the higher annualized total return — SYK at 11.71% versus VRTX at 17.33%. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Stryker P/E ratioVertex Pharmaceuticals P/E ratioStryker dividend yieldVertex Pharmaceuticals dividend yieldStryker ROEVertex Pharmaceuticals ROEStryker operating marginVertex Pharmaceuticals operating marginStryker revenue growthVertex Pharmaceuticals revenue growthStryker free cash flowVertex Pharmaceuticals free cash flow
Stryker & Vertex Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 17, 2026.