Pfizer Inc. (PFE) vs Vertex Pharmaceuticals Incorporated (VRTX)
A side-by-side comparison of Pfizer Inc. and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of July 30, 2026. Differences are shown without an overall score or investment verdict.
PFE
Pfizer Inc.
$24.58HealthcareDelayed quote: Jul 30, 2026, 10:15 AM EDT
VRTX
Vertex Pharmaceuticals Incorporated
$473.07HealthcareDelayed quote: Jul 30, 2026, 10:15 AM EDT
Total return — PFE vs VRTX
growth of $100 · dividends reinvested · last 30yPFE +559.3%VRTX +3582.5%VRTX compounded faster
Log scale — wide-divergence pair
PFE VRTX
PFE vs VRTX: by the numbers
- •PFE is the larger company ($140.06B vs $120.07B market cap).
- •PFE trades at the lower trailing earnings multiple (19.20 vs 28.67 P/E), one valuation lens rather than an overall verdict.
- •VRTX converts more revenue to profit (35.40% vs 11.83% net margin).
- •VRTX grew revenue faster over the past five years (13.82% vs 8.22% CAGR).
- •PFE pays a dividend (6.84% yield), while VRTX has no payments in the available dividend history.
Metrics side by side
Valuation
| Metric | PFE | VRTX |
|---|---|---|
| P/E ratio | 19.20 | 28.67 |
| Forward P/E | 8.54 | 25.14 |
| P/S ratio | 2.28 | 10.11 |
| P/B ratio | 1.60 | 6.40 |
| PEG ratio | N/A | 3.51 |
| EV / EBITDA | 9.85 | 24.12 |
| FCF yield | 6.58% | 2.99% |
Profitability
| Metric | PFE | VRTX |
|---|---|---|
| Gross margin | 69.35% | 86.28% |
| Operating margin | 23.45% | 38.97% |
| Net margin | 11.83% | 35.40% |
| ROE | 8.31% | 22.41% |
| ROIC | 8.84% | 18.12% |
Dividends
| Metric | PFE | VRTX |
|---|---|---|
| Dividend yield | 6.84% | N/A |
| Payout ratio | 126.47% | N/A |
Growth (annualized)
| Metric | PFE | VRTX |
|---|---|---|
| Revenue CAGR (5Y) | 8.22% | 13.82% |
| EPS CAGR (5Y) | -3.78% | 8.17% |
| FCF CAGR (5Y) | -3.79% | 4.01% |
| Total return CAGR (5Y) | -5.18% | 19.26% |
Frequently asked
- Which has the lower trailing P/E, PFE or VRTX?
- PFE has the lower trailing P/E: PFE trades at 19.20 and VRTX at 28.67. P/E is one valuation measure and does not by itself establish which business is cheaper.
- Which has grown faster, PFE or VRTX?
- Over the past five years, VRTX grew revenue faster — PFE at a 8.22% CAGR versus VRTX at 13.82%.
- Does PFE or VRTX pay a bigger dividend?
- PFE pays a dividend (6.84% yield), while VRTX has no payments in the available dividend history.
- Is PFE or VRTX more profitable?
- VRTX runs the higher net margin — PFE at 11.83% versus VRTX at 35.40%.
- How have PFE and VRTX total returns compared?
- Over the past 10 years, PFE delivered 1.44% and VRTX delivered 17.42% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Pfizer P/E ratioVertex Pharmaceuticals P/E ratioPfizer dividend yieldVertex Pharmaceuticals dividend yieldPfizer ROEVertex Pharmaceuticals ROEPfizer operating marginVertex Pharmaceuticals operating marginPfizer revenue growthVertex Pharmaceuticals revenue growthPfizer free cash flowVertex Pharmaceuticals free cash flow
Pfizer & Vertex Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified July 30, 2026.