Which has the lower trailing P/E, PFE or VRTX?

VRTX has the lower trailing P/E: PFE trades at 36.63 and VRTX at 30.00. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, PFE or VRTX?

Over the past five years, VRTX grew revenue faster — PFE at a 6.29% CAGR versus VRTX at 13.57%.

Does PFE or VRTX pay a bigger dividend?

PFE pays a dividend (6.20% yield), while VRTX has no payments in the available dividend history.

Is PFE or VRTX more profitable?

VRTX runs the higher net margin — PFE at 6.81% versus VRTX at 34.89%.

How have PFE and VRTX total returns compared?

Over the past 10 years, PFE delivered 3.15% and VRTX delivered 18.72% annualized total return. Past performance doesn't predict future results.

Pfizer Inc. (PFE) vs Vertex Pharmaceuticals Incorporated (VRTX)

A side-by-side comparison of Pfizer Inc. and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of September 13, 2026. Differences are shown without an overall score or investment verdict.

PFE

Pfizer Inc.

$157.99B

$27.72HealthcareDelayed quote: Sep 11, 2026, 4:01 PM EDT

VRTX

Vertex Pharmaceuticals Incorporated

$130.82B

$515.44HealthcareDelayed quote: Sep 11, 2026, 4:00 PM EDT

Total return — PFE vs VRTX

growth of $100 · dividends reinvested · last 10y

PFE +42.4% (+3.6%/yr)VRTX +462.1% (+18.8%/yr)VRTX compounded faster over this window

PFE VRTX

PFE vs VRTX: by the numbers

•PFE is the larger company ($157.99B vs $130.82B market cap).
•VRTX trades at the lower trailing earnings multiple (30.00 vs 36.63 P/E), one valuation lens rather than an overall verdict.
•VRTX converts more revenue to profit (34.89% vs 6.81% net margin).
•VRTX grew revenue faster over the past five years (13.57% vs 6.29% CAGR).
•PFE pays a dividend (6.20% yield), while VRTX has no payments in the available dividend history.

Metrics side by side

Valuation

Metric	PFE	VRTX
P/E ratio	36.63	30.00
Forward P/E	9.32	27.49
P/S ratio	2.48	10.36
P/B ratio	1.85	6.46
EV / EBITDA	10.15	24.88
FCF yield	6.95%	2.90%

Profitability

Metric	PFE	VRTX
Gross margin	71.32%	86.04%
Operating margin	25.08%	38.59%
Net margin	6.81%	34.89%
ROE	5.09%	21.76%
ROIC	9.33%	17.33%

Dividends

Metric	PFE	VRTX
Dividend yield	6.20%	N/A
Payout ratio	227.27%	N/A

Growth (annualized)

Metric	PFE	VRTX
Revenue CAGR (5Y)	6.29%	13.57%
EPS CAGR (5Y)	-3.78%	8.17%
FCF CAGR (5Y)	-3.11%	16.39%
Total return CAGR (5Y)	-4.53%	22.61%

Frequently asked

Which has the lower trailing P/E, PFE or VRTX?: VRTX has the lower trailing P/E: PFE trades at 36.63 and VRTX at 30.00. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, PFE or VRTX?: Over the past five years, VRTX grew revenue faster — PFE at a 6.29% CAGR versus VRTX at 13.57%.
Does PFE or VRTX pay a bigger dividend?: PFE pays a dividend (6.20% yield), while VRTX has no payments in the available dividend history.
Is PFE or VRTX more profitable?: VRTX runs the higher net margin — PFE at 6.81% versus VRTX at 34.89%.
How have PFE and VRTX total returns compared?: Over the past 10 years, PFE delivered 3.15% and VRTX delivered 18.72% annualized total return. Past performance doesn't predict future results.

Go deeper

Full PFE analysis Full VRTX analysis Interactive comparison tool

Dig into the metrics

Pfizer P/E ratio Vertex Pharmaceuticals P/E ratio Pfizer dividend yield Pfizer ROE Vertex Pharmaceuticals ROE Pfizer operating margin Vertex Pharmaceuticals operating margin Pfizer revenue growth Vertex Pharmaceuticals revenue growth Pfizer free cash flow Vertex Pharmaceuticals free cash flow

Pfizer & Vertex Pharmaceuticals appear in these rankings

Highest Dividend Yield Stocks Highest Operating Margin Stocks Highest FCF Yield Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified September 13, 2026.