Is PCVX or PODD more profitable?

PODD runs the higher net margin — PCVX at 0.00% versus PODD at 12.29%.

How have PCVX and PODD total returns compared?

Over the past 5 years, PCVX delivered 25.08% and PODD delivered -13.93% annualized total return. Past performance doesn't predict future results.

Vaxcyte, Inc. (PCVX) vs Insulet Corp. (PODD)

A side-by-side comparison of Vaxcyte, Inc. and Insulet Corp. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

PCVX

Vaxcyte, Inc.

$9.34B

$64.67HealthcareDelayed quote: Oct 6, 2026, 1:55 PM EDT

PODD

Insulet Corp.

$9.38B

$135.48HealthcareDelayed quote: Oct 6, 2026, 1:55 PM EDT

Total return — PCVX vs PODD

growth of $100 · dividends reinvested · last 6y

PCVX +182.3% (+18.9%/yr)PODD -25.4% (-4.8%/yr)PCVX compounded faster over this window

PCVX PODD

PCVX vs PODD: by the numbers

•PODD is the larger company ($9.38B vs $9.34B market cap).
•PODD is profitable (12.29% net margin) while PCVX runs a net loss (0.00%).

Metrics side by side

Valuation

Metric	PCVX	PODD
P/E ratio	N/A	25.32
Forward P/E	N/A	20.83
PEG ratio	N/A	0.24
P/S ratio	N/A	3.07
P/B ratio	3.39	6.60
EV / EBITDA	N/A	15.77
FCF yield	N/A	3.18%

Profitability

Metric	PCVX	PODD
Gross margin	0.00%	71.08%
Operating margin	0.00%	16.89%
Net margin	0.00%	12.29%
ROE	-38.59%	26.39%
ROIC	-40.65%	16.04%

Growth (annualized)

Metric	PCVX	PODD
Revenue CAGR (5Y)	N/A	25.13%
EPS CAGR (5Y)	N/A	99.91%
Total return CAGR (5Y)	25.08%	-13.93%

Frequently asked

Is PCVX or PODD more profitable?: PODD runs the higher net margin — PCVX at 0.00% versus PODD at 12.29%.
How have PCVX and PODD total returns compared?: Over the past 5 years, PCVX delivered 25.08% and PODD delivered -13.93% annualized total return. Past performance doesn't predict future results.

Go deeper

Full PCVX analysis Full PODD analysis Interactive comparison tool

Dig into the metrics

Insulet P/E ratio Vaxcyte ROE Insulet ROE Vaxcyte operating margin Insulet operating margin Vaxcyte revenue growth Insulet revenue growth Vaxcyte free cash flow Insulet free cash flow

Vaxcyte & Insulet appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.