Nektar Therapeutics (NKTR) vs OPKO Health, Inc. (OPK)
A side-by-side comparison of Nektar Therapeutics and OPKO Health, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
NKTR
Nektar Therapeutics
$39.88HealthcareDelayed quote: Oct 6, 2026, 3:00 PM EDT
OPK
OPKO Health, Inc.
$1.46HealthcareDelayed quote: Oct 6, 2026, 3:00 PM EDT
Total return — NKTR vs OPK
growth of $100 · dividends reinvested · last 10yNKTR -82.3% (-15.9%/yr)OPK -83.4% (-16.4%/yr)NKTR compounded faster over this window
NKTR OPK
NKTR vs OPK: by the numbers
- •NKTR is the larger company ($1.14B vs $1.09B market cap).
- •Both run net losses; OPK's is the smaller (-12.40% vs -287.84% net margin).
- •Both shrank revenue over the past five years; NKTR's decline was smaller (-12.34% vs -21.00% CAGR).
Metrics side by side
Valuation
| Metric | NKTR | OPK |
|---|---|---|
| P/S ratio | 20.96 | 1.86 |
| P/B ratio | 1.27 | 0.92 |
Profitability
| Metric | NKTR | OPK |
|---|---|---|
| Gross margin | 99.36% | 21.10% |
| Operating margin | -240.38% | -36.08% |
| Net margin | -287.84% | -12.40% |
| ROE | -17.40% | -6.16% |
| ROIC | -12.53% | -8.86% |
Growth (annualized)
| Metric | NKTR | OPK |
|---|---|---|
| Revenue CAGR (5Y) | -12.34% | -21.00% |
| Total return CAGR (5Y) | -30.33% | -15.39% |
Frequently asked
- Which has grown faster, NKTR or OPK?
- Neither grew: over the past five years both shrank revenue, with NKTR's decline the smaller — NKTR at a -12.34% CAGR versus OPK at -21.00%.
- How have NKTR and OPK total returns compared?
- Over the past 10 years, NKTR delivered -16.49% and OPK delivered -17.50% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.