Medtronic plc (MDT) vs Vertex Pharmaceuticals Incorporated (VRTX)
A side-by-side comparison of Medtronic plc and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of July 28, 2026. Differences are shown without an overall score or investment verdict.
MDT
Medtronic plc
$86.88HealthcareDelayed quote: Jul 28, 2026, 4:00 PM EDT
VRTX
Vertex Pharmaceuticals Incorporated
$490.39HealthcareDelayed quote: Jul 28, 2026, 4:00 PM EDT
Total return — MDT vs VRTX
growth of $100 · dividends reinvested · last 30yMDT +1080.2%VRTX +3537.0%VRTX compounded faster
MDT VRTX
MDT vs VRTX: by the numbers
- •VRTX is the larger company ($124.46B vs $111.21B market cap).
- •MDT trades at the lower trailing earnings multiple (22.58 vs 28.41 P/E), one valuation lens rather than an overall verdict.
- •VRTX converts more revenue to profit (35.40% vs 13.20% net margin).
- •VRTX grew revenue faster over the past five years (13.82% vs 5.18% CAGR).
- •MDT pays a dividend (3.38% yield), while VRTX has no payments in the available dividend history.
Metrics side by side
Valuation
| Metric | MDT | VRTX |
|---|---|---|
| P/E ratio | 22.58 | 28.41 |
| Forward P/E | 15.26 | 24.91 |
| P/S ratio | 2.98 | 10.02 |
| P/B ratio | 2.19 | 6.34 |
| PEG ratio | 6.72 | 3.48 |
| EV / EBITDA | 14.41 | 23.90 |
| FCF yield | 5.00% | 3.02% |
Profitability
| Metric | MDT | VRTX |
|---|---|---|
| Gross margin | 65.02% | 86.28% |
| Operating margin | 17.78% | 38.97% |
| Net margin | 13.20% | 35.40% |
| ROE | 9.70% | 22.41% |
| ROIC | 6.13% | 18.12% |
Dividends
| Metric | MDT | VRTX |
|---|---|---|
| Dividend yield | 3.38% | N/A |
| Payout ratio | 76.00% | N/A |
Growth (annualized)
| Metric | MDT | VRTX |
|---|---|---|
| Revenue CAGR (5Y) | 5.18% | 13.82% |
| EPS CAGR (5Y) | 0.83% | 8.17% |
| FCF CAGR (5Y) | 3.07% | 4.01% |
| Total return CAGR (5Y) | -5.43% | 19.51% |
Frequently asked
- Which has the lower trailing P/E, MDT or VRTX?
- MDT has the lower trailing P/E: MDT trades at 22.58 and VRTX at 28.41. P/E is one valuation measure and does not by itself establish which business is cheaper.
- Which has grown faster, MDT or VRTX?
- Over the past five years, VRTX grew revenue faster — MDT at a 5.18% CAGR versus VRTX at 13.82%.
- Does MDT or VRTX pay a bigger dividend?
- MDT pays a dividend (3.38% yield), while VRTX has no payments in the available dividend history.
- Is MDT or VRTX more profitable?
- VRTX runs the higher net margin — MDT at 13.20% versus VRTX at 35.40%.
- How have MDT and VRTX total returns compared?
- Over the past 10 years, MDT delivered 2.30% and VRTX delivered 17.75% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Medtronic P/E ratioVertex Pharmaceuticals P/E ratioMedtronic dividend yieldVertex Pharmaceuticals dividend yieldMedtronic ROEVertex Pharmaceuticals ROEMedtronic operating marginVertex Pharmaceuticals operating marginMedtronic revenue growthVertex Pharmaceuticals revenue growthMedtronic free cash flowVertex Pharmaceuticals free cash flow
Medtronic & Vertex Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified July 28, 2026.