Which has the lower trailing P/E, MDT or VRTX?

MDT has the lower trailing P/E: MDT trades at 22.40 and VRTX at 30.00. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, MDT or VRTX?

Over the past five years, VRTX grew revenue faster — MDT at a 3.51% CAGR versus VRTX at 13.57%.

Does MDT or VRTX pay a bigger dividend?

MDT pays a dividend (3.11% yield), while VRTX has no payments in the available dividend history.

Is MDT or VRTX more profitable?

VRTX runs the higher net margin — MDT at 13.93% versus VRTX at 34.89%.

How have MDT and VRTX total returns compared?

Over the past 10 years, MDT delivered 3.48% and VRTX delivered 18.72% annualized total return. Past performance doesn't predict future results.

Medtronic plc (MDT) vs Vertex Pharmaceuticals Incorporated (VRTX)

A side-by-side comparison of Medtronic plc and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of September 11, 2026. Differences are shown without an overall score or investment verdict.

MDT

Medtronic plc

$116.43B

$90.96HealthcareDelayed quote: Sep 11, 2026, 4:00 PM EDT

VRTX

Vertex Pharmaceuticals Incorporated

$130.82B

$515.44HealthcareDelayed quote: Sep 11, 2026, 4:00 PM EDT

Total return — MDT vs VRTX

growth of $100 · dividends reinvested · last 10y

MDT +41.2% (+3.5%/yr)VRTX +462.1% (+18.8%/yr)VRTX compounded faster over this window

MDT VRTX

MDT vs VRTX: by the numbers

•VRTX is the larger company ($130.82B vs $116.43B market cap).
•MDT trades at the lower trailing earnings multiple (22.40 vs 30.00 P/E), one valuation lens rather than an overall verdict.
•VRTX converts more revenue to profit (34.89% vs 13.93% net margin).
•VRTX grew revenue faster over the past five years (13.57% vs 3.51% CAGR).
•MDT pays a dividend (3.11% yield), while VRTX has no payments in the available dividend history.

Metrics side by side

Valuation

Metric	MDT	VRTX
P/E ratio	22.40	30.00
Forward P/E	15.23	27.49
P/S ratio	3.10	10.36
P/B ratio	2.32	6.46
EV / EBITDA	14.83	24.88
FCF yield	5.27%	2.90%

Profitability

Metric	MDT	VRTX
Gross margin	66.69%	86.04%
Operating margin	18.08%	38.59%
Net margin	13.93%	34.89%
ROE	10.41%	21.76%
ROIC	6.44%	17.33%

Dividends

Metric	MDT	VRTX
Dividend yield	3.11%	N/A
Payout ratio	70.20%	N/A

Growth (annualized)

Metric	MDT	VRTX
Revenue CAGR (5Y)	3.51%	13.57%
EPS CAGR (5Y)	6.97%	8.17%
FCF CAGR (5Y)	0.93%	16.39%
Total return CAGR (5Y)	-3.96%	22.61%

Frequently asked

Which has the lower trailing P/E, MDT or VRTX?: MDT has the lower trailing P/E: MDT trades at 22.40 and VRTX at 30.00. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, MDT or VRTX?: Over the past five years, VRTX grew revenue faster — MDT at a 3.51% CAGR versus VRTX at 13.57%.
Does MDT or VRTX pay a bigger dividend?: MDT pays a dividend (3.11% yield), while VRTX has no payments in the available dividend history.
Is MDT or VRTX more profitable?: VRTX runs the higher net margin — MDT at 13.93% versus VRTX at 34.89%.
How have MDT and VRTX total returns compared?: Over the past 10 years, MDT delivered 3.48% and VRTX delivered 18.72% annualized total return. Past performance doesn't predict future results.

Go deeper

Full MDT analysis Full VRTX analysis Interactive comparison tool

Dig into the metrics

Medtronic P/E ratio Vertex Pharmaceuticals P/E ratio Medtronic dividend yield Medtronic ROE Vertex Pharmaceuticals ROE Medtronic operating margin Vertex Pharmaceuticals operating margin Medtronic revenue growth Vertex Pharmaceuticals revenue growth Medtronic free cash flow Vertex Pharmaceuticals free cash flow

Medtronic & Vertex Pharmaceuticals appear in these rankings

Highest Dividend Yield Stocks 25+ Year Dividend Growers Highest Operating Margin Stocks Highest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified September 11, 2026.