Which has the lower trailing P/E, KRYS or PODD?

PODD has the lower trailing P/E: KRYS trades at 41.43 and PODD at 25.36. P/E is one valuation measure and does not by itself establish which business is cheaper.

Is KRYS or PODD more profitable?

KRYS runs the higher net margin — KRYS at 54.82% versus PODD at 12.29%.

How have KRYS and PODD total returns compared?

Over the past 5 years, KRYS delivered 44.28% and PODD delivered -13.93% annualized total return. Past performance doesn't predict future results.

Krystal Biotech, Inc. (KRYS) vs Insulet Corp. (PODD)

A side-by-side comparison of Krystal Biotech, Inc. and Insulet Corp. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

KRYS

Krystal Biotech, Inc.

$9.75B

$330.63HealthcareDelayed quote: Oct 6, 2026, 12:15 PM EDT

PODD

Insulet Corp.

$9.40B

$135.69HealthcareDelayed quote: Oct 6, 2026, 12:15 PM EDT

Total return — KRYS vs PODD

growth of $100 · dividends reinvested · last 9y

KRYS +3047.1% (+46.7%/yr)PODD +131.0% (+9.7%/yr)KRYS compounded faster over this window

Log scale — wide-divergence pair

KRYS PODD

KRYS vs PODD: by the numbers

•KRYS is the larger company ($9.75B vs $9.40B market cap).
•PODD trades at the lower trailing earnings multiple (25.36 vs 41.43 P/E), one valuation lens rather than an overall verdict.
•KRYS converts more revenue to profit (54.82% vs 12.29% net margin).

Metrics side by side

Valuation

Metric	KRYS	PODD
P/E ratio	41.43	25.36
Forward P/E	43.46	20.87
PEG ratio	N/A	0.25
P/S ratio	22.13	3.08
P/B ratio	7.17	6.61
EV / EBITDA	45.64	15.79
FCF yield	2.64%	3.17%

Profitability

Metric	KRYS	PODD
Gross margin	93.34%	71.08%
Operating margin	44.93%	16.89%
Net margin	54.82%	12.29%
ROE	17.77%	26.39%
ROIC	14.41%	16.04%

Growth (annualized)

Metric	KRYS	PODD
Revenue CAGR (5Y)	N/A	25.13%
EPS CAGR (5Y)	N/A	99.91%
Total return CAGR (5Y)	44.28%	-13.93%

Frequently asked

Which has the lower trailing P/E, KRYS or PODD?: PODD has the lower trailing P/E: KRYS trades at 41.43 and PODD at 25.36. P/E is one valuation measure and does not by itself establish which business is cheaper.
Is KRYS or PODD more profitable?: KRYS runs the higher net margin — KRYS at 54.82% versus PODD at 12.29%.
How have KRYS and PODD total returns compared?: Over the past 5 years, KRYS delivered 44.28% and PODD delivered -13.93% annualized total return. Past performance doesn't predict future results.

Go deeper

Full KRYS analysis Full PODD analysis Interactive comparison tool

Dig into the metrics

Krystal Biotech P/E ratio Insulet P/E ratio Krystal Biotech ROE Insulet ROE Krystal Biotech operating margin Insulet operating margin Krystal Biotech revenue growth Insulet revenue growth Krystal Biotech free cash flow Insulet free cash flow

Krystal Biotech & Insulet appear in these rankings

Fastest Revenue Growth Stocks Highest ROE Stocks Highest Operating Margin Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.