Karyopharm Therapeutics Inc. (KPTI) vs Optimi Health Corp. (OPTH)
A side-by-side comparison of Karyopharm Therapeutics Inc. and Optimi Health Corp. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
KPTI
Karyopharm Therapeutics Inc.
$0.67HealthcareDelayed quote: Oct 6, 2026, 11:31 AM EDT
OPTH
Optimi Health Corp.
$4.18HealthcareDelayed quote: Oct 6, 2026, 11:30 AM EDT
Total return — KPTI vs OPTH
growth of $100 · dividends reinvested · last 6yKPTI -99.6% (-59.4%/yr)OPTH -74.5% (-20.4%/yr)OPTH compounded faster over this window
Log scale — wide-divergence pair
KPTI OPTH
KPTI vs OPTH: by the numbers
- •KPTI is the larger company ($15M vs $13M market cap).
- •Both run net losses; KPTI's is the smaller (-153.28% vs -3972.87% net margin).
Metrics side by side
Valuation
| Metric | KPTI | OPTH |
|---|---|---|
| P/S ratio | 0.10 | 108.20 |
| P/B ratio | N/A | 1.08 |
Profitability
| Metric | KPTI | OPTH |
|---|---|---|
| Gross margin | 95.88% | -486.44% |
| Operating margin | -56.17% | -1062.29% |
| Net margin | -153.28% | -3972.87% |
| ROE | N/A | -39.76% |
| ROIC | N/A | -28.72% |
Growth (annualized)
| Metric | KPTI | OPTH |
|---|---|---|
| Revenue CAGR (5Y) | 7.47% | N/A |
| Total return CAGR (5Y) | -62.18% | -21.80% |
Frequently asked
- How have KPTI and OPTH total returns compared?
- Over the past 5 years, KPTI delivered -62.18% and OPTH delivered -21.80% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.