Which has the lower trailing P/E, ISRG or VRTX?

VRTX has the lower trailing P/E: ISRG trades at 42.00 and VRTX at 30.00. P/E is one valuation measure and does not by itself establish which business is cheaper.

Which has grown faster, ISRG or VRTX?

Over the past five years, ISRG grew revenue faster — ISRG at a 16.41% CAGR versus VRTX at 13.57%.

Is ISRG or VRTX more profitable?

VRTX runs the higher net margin — ISRG at 28.45% versus VRTX at 34.89%.

How have ISRG and VRTX total returns compared?

Over the past 10 years, ISRG delivered 16.97% and VRTX delivered 18.72% annualized total return. Past performance doesn't predict future results.

Intuitive Surgical, Inc. (ISRG) vs Vertex Pharmaceuticals Incorporated (VRTX)

A side-by-side comparison of Intuitive Surgical, Inc. and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of September 10, 2026. Differences are shown without an overall score or investment verdict.

ISRG

Intuitive Surgical, Inc.

$130.41B

$369.15HealthcareDelayed quote: Sep 11, 2026, 4:00 PM EDT

VRTX

Vertex Pharmaceuticals Incorporated

$130.82B

$515.44HealthcareDelayed quote: Sep 11, 2026, 4:00 PM EDT

Total return — ISRG vs VRTX

growth of $100 · dividends reinvested · last 10y

ISRG +359.2% (+16.5%/yr)VRTX +462.1% (+18.8%/yr)VRTX compounded faster over this window

ISRG VRTX

ISRG vs VRTX: by the numbers

•VRTX is the larger company ($130.82B vs $130.41B market cap).
•VRTX trades at the lower trailing earnings multiple (30.00 vs 42.00 P/E), one valuation lens rather than an overall verdict.
•VRTX converts more revenue to profit (34.89% vs 28.45% net margin).
•ISRG grew revenue faster over the past five years (16.41% vs 13.57% CAGR).

Metrics side by side

Valuation

Metric	ISRG	VRTX
P/E ratio	42.00	30.00
Forward P/E	34.18	27.49
P/S ratio	11.82	10.36
P/B ratio	7.18	6.46
EV / EBITDA	30.16	24.88
FCF yield	2.47%	2.90%

Profitability

Metric	ISRG	VRTX
Gross margin	66.68%	86.04%
Operating margin	31.28%	38.59%
Net margin	28.45%	34.89%
ROE	17.28%	21.76%
ROIC	15.11%	17.33%

Growth (annualized)

Metric	ISRG	VRTX
Revenue CAGR (5Y)	16.41%	13.57%
EPS CAGR (5Y)	21.51%	8.17%
FCF CAGR (5Y)	14.17%	16.39%
Total return CAGR (5Y)	1.11%	22.61%

Frequently asked

Which has the lower trailing P/E, ISRG or VRTX?: VRTX has the lower trailing P/E: ISRG trades at 42.00 and VRTX at 30.00. P/E is one valuation measure and does not by itself establish which business is cheaper.
Which has grown faster, ISRG or VRTX?: Over the past five years, ISRG grew revenue faster — ISRG at a 16.41% CAGR versus VRTX at 13.57%.
Is ISRG or VRTX more profitable?: VRTX runs the higher net margin — ISRG at 28.45% versus VRTX at 34.89%.
How have ISRG and VRTX total returns compared?: Over the past 10 years, ISRG delivered 16.97% and VRTX delivered 18.72% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ISRG analysis Full VRTX analysis Interactive comparison tool

Dig into the metrics

Intuitive Surgical P/E ratio Vertex Pharmaceuticals P/E ratio Intuitive Surgical ROE Vertex Pharmaceuticals ROE Intuitive Surgical operating margin Vertex Pharmaceuticals operating margin Intuitive Surgical revenue growth Vertex Pharmaceuticals revenue growth Intuitive Surgical free cash flow Vertex Pharmaceuticals free cash flow

Intuitive Surgical & Vertex Pharmaceuticals appear in these rankings

Fastest Revenue Growth Stocks Highest Operating Margin Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified September 10, 2026.