Is ISRG or VRTX cheaper?

On trailing earnings, VRTX is cheaper: ISRG trades at a 49.83 P/E and VRTX at 26.39.

Which has grown faster, ISRG or VRTX?

Over the past five years, ISRG grew revenue faster — ISRG at a 18.39% CAGR versus VRTX at 13.82%.

Is ISRG or VRTX more profitable?

VRTX runs the higher net margin — ISRG at 28.15% versus VRTX at 35.40%.

Which has been the better investment, ISRG or VRTX?

Over the past 10-year, ISRG delivered the higher annualized total return — ISRG at 19.14% versus VRTX at 17.13%. Past performance doesn't predict future results.

Intuitive Surgical, Inc. (ISRG) vs Vertex Pharmaceuticals Incorporated (VRTX)

VRTX leads on 12 of 15 compared metrics.

A side-by-side comparison of Intuitive Surgical, Inc. and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 15, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).

ISRG

Intuitive Surgical, Inc.

$145.58B

$411.06Healthcare

VRTX

Vertex Pharmaceuticals Incorporated

$112.92B

$444.93Healthcare

Total return — ISRG vs VRTX

growth of $100 · last 26y

ISRG +20149.3%VRTX +954.6%ISRG compounded faster

Log scale — wide-divergence pair

ISRG VRTX

ISRG vs VRTX: by the numbers

•ISRG is the larger company ($145.58B vs $112.92B market cap).
•VRTX trades at the lower earnings multiple (26.39 vs 49.83 P/E).
•VRTX converts more revenue to profit (35.40% vs 28.15% net margin).
•ISRG grew revenue faster over the past five years (18.39% vs 13.82% CAGR).

Which is better, ISRG or VRTX?

Metric tally: ISRG 3 · VRTX 12

It depends on what you're optimizing for:

ValueVRTX(lower P/E)

GrowthISRG(faster 5Y revenue CAGR)

QualityVRTX(higher ROIC)

Metrics side by side

Valuation

Metric	ISRG	VRTX
P/E ratio	49.83	26.39●
Forward P/E	34.92	20.58●
P/S ratio	13.98	9.31●
P/B ratio	8.46	5.89●
PEG ratio	3.17	3.23
EV / EBITDA	35.41	20.72●
FCF yield	1.92%	3.25%●

Profitability

Metric	ISRG	VRTX
Gross margin	66.29%	86.28%●
Operating margin	30.45%	38.97%●
Net margin	28.15%	35.40%●
ROE	17.05%	22.41%●
ROIC	13.71%	18.12%●

Growth (annualized)

Metric	ISRG	VRTX
Revenue CAGR (5Y)	18.39%●	13.82%
EPS CAGR (5Y)	21.51%●	8.17%
FCF CAGR (5Y)	16.61%●	4.01%
Total return CAGR (5Y)	7.37%	18.17%●

Frequently asked

Which is better, ISRG or VRTX?: It depends on your goal. value: VRTX (lower P/E); growth: ISRG (faster 5Y revenue CAGR); quality: VRTX (higher ROIC). Across all compared metrics, VRTX leads 12 to 3.
Is ISRG or VRTX cheaper?: On trailing earnings, VRTX is cheaper: ISRG trades at a 49.83 P/E and VRTX at 26.39.
Which has grown faster, ISRG or VRTX?: Over the past five years, ISRG grew revenue faster — ISRG at a 18.39% CAGR versus VRTX at 13.82%.
Is ISRG or VRTX more profitable?: VRTX runs the higher net margin — ISRG at 28.15% versus VRTX at 35.40%.
Which has been the better investment, ISRG or VRTX?: Over the past 10-year, ISRG delivered the higher annualized total return — ISRG at 19.14% versus VRTX at 17.13%. Past performance doesn't predict future results.

Go deeper

Full ISRG analysis Full VRTX analysis Interactive comparison tool

Dig into the metrics

Intuitive Surgical P/E ratio Vertex Pharmaceuticals P/E ratio Intuitive Surgical dividend yield Vertex Pharmaceuticals dividend yield Intuitive Surgical ROE Vertex Pharmaceuticals ROE Intuitive Surgical operating margin Vertex Pharmaceuticals operating margin Intuitive Surgical revenue growth Vertex Pharmaceuticals revenue growth Intuitive Surgical free cash flow Vertex Pharmaceuticals free cash flow

Intuitive Surgical & Vertex Pharmaceuticals appear in these rankings

Fastest Revenue Growth Stocks Highest ROIC Stocks Highest Operating Margin Stocks Best 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 15, 2026.