Gilead Sciences, Inc. (GILD) vs Vertex Pharmaceuticals Incorporated (VRTX)
A side-by-side comparison of Gilead Sciences, Inc. and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of September 11, 2026. Differences are shown without an overall score or investment verdict.
GILD
Gilead Sciences, Inc.
$143.72HealthcareDelayed quote: Sep 11, 2026, 4:00 PM EDT
VRTX
Vertex Pharmaceuticals Incorporated
$515.44HealthcareDelayed quote: Sep 11, 2026, 4:00 PM EDT
Total return — GILD vs VRTX
growth of $100 · dividends reinvested · last 10yGILD +164.6% (+10.2%/yr)VRTX +462.1% (+18.8%/yr)VRTX compounded faster over this window
GILD VRTX
GILD vs VRTX: by the numbers
- •GILD is the larger company ($178.44B vs $130.82B market cap).
- •VRTX is profitable (34.89% net margin) while GILD runs a net loss (-10.64%).
- •VRTX grew revenue faster over the past five years (13.57% vs 2.72% CAGR).
- •GILD pays a dividend (2.22% yield), while VRTX has no payments in the available dividend history.
Metrics side by side
Valuation
| Metric | GILD | VRTX |
|---|---|---|
| P/E ratio | N/A | 30.00 |
| Forward P/E | N/A | 27.49 |
| P/S ratio | 5.86 | 10.36 |
| P/B ratio | 15.09 | 6.46 |
| EV / EBITDA | N/A | 24.88 |
| FCF yield | 7.27% | 2.90% |
Profitability
| Metric | GILD | VRTX |
|---|---|---|
| Gross margin | 79.59% | 86.04% |
| Operating margin | 39.74% | 38.59% |
| Net margin | -10.64% | 34.89% |
| ROE | -27.39% | 21.76% |
| ROIC | -3.66% | 17.33% |
Dividends
| Metric | GILD | VRTX |
|---|---|---|
| Dividend yield | 2.22% | N/A |
Growth (annualized)
| Metric | GILD | VRTX |
|---|---|---|
| Revenue CAGR (5Y) | 2.72% | 13.57% |
| EPS CAGR (5Y) | 133.83% | 8.17% |
| FCF CAGR (5Y) | 9.27% | 16.39% |
| Total return CAGR (5Y) | 19.60% | 22.61% |
Frequently asked
- Which has grown faster, GILD or VRTX?
- Over the past five years, VRTX grew revenue faster — GILD at a 2.72% CAGR versus VRTX at 13.57%.
- Does GILD or VRTX pay a bigger dividend?
- GILD pays a dividend (2.22% yield), while VRTX has no payments in the available dividend history.
- Is GILD or VRTX more profitable?
- VRTX runs the higher net margin — GILD at -10.64% versus VRTX at 34.89%.
- How have GILD and VRTX total returns compared?
- Over the past 10 years, GILD delivered 10.21% and VRTX delivered 18.72% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Vertex Pharmaceuticals P/E ratioGilead Sciences dividend yieldGilead Sciences ROEVertex Pharmaceuticals ROEGilead Sciences operating marginVertex Pharmaceuticals operating marginGilead Sciences revenue growthVertex Pharmaceuticals revenue growthGilead Sciences free cash flowVertex Pharmaceuticals free cash flow
Gilead Sciences & Vertex Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified September 11, 2026.