Gilead Sciences, Inc. (GILD) vs Vertex Pharmaceuticals Incorporated (VRTX)

A side-by-side comparison of Gilead Sciences, Inc. and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of September 11, 2026. Differences are shown without an overall score or investment verdict.

Compare

Total returnGILD vs VRTX

growth of $100 · dividends reinvested · last 10y
GILD +164.6% (+10.2%/yr)VRTX +462.1% (+18.8%/yr)VRTX compounded faster over this window
200400600Start $10020182020202220242026$265$562
GILD VRTX

GILD vs VRTX: by the numbers

  • GILD is the larger company ($178.44B vs $130.82B market cap).
  • VRTX is profitable (34.89% net margin) while GILD runs a net loss (-10.64%).
  • VRTX grew revenue faster over the past five years (13.57% vs 2.72% CAGR).
  • GILD pays a dividend (2.22% yield), while VRTX has no payments in the available dividend history.

Metrics side by side

Valuation

MetricGILDVRTX
P/E ratioN/A30.00
Forward P/EN/A27.49
P/S ratio5.8610.36
P/B ratio15.096.46
EV / EBITDAN/A24.88
FCF yield7.27%2.90%

Profitability

MetricGILDVRTX
Gross margin79.59%86.04%
Operating margin39.74%38.59%
Net margin-10.64%34.89%
ROE-27.39%21.76%
ROIC-3.66%17.33%

Dividends

MetricGILDVRTX
Dividend yield2.22%N/A

Growth (annualized)

MetricGILDVRTX
Revenue CAGR (5Y)2.72%13.57%
EPS CAGR (5Y)133.83%8.17%
FCF CAGR (5Y)9.27%16.39%
Total return CAGR (5Y)19.60%22.61%

Frequently asked

Which has grown faster, GILD or VRTX?
Over the past five years, VRTX grew revenue faster — GILD at a 2.72% CAGR versus VRTX at 13.57%.
Does GILD or VRTX pay a bigger dividend?
GILD pays a dividend (2.22% yield), while VRTX has no payments in the available dividend history.
Is GILD or VRTX more profitable?
VRTX runs the higher net margin — GILD at -10.64% versus VRTX at 34.89%.
How have GILD and VRTX total returns compared?
Over the past 10 years, GILD delivered 10.21% and VRTX delivered 18.72% annualized total return. Past performance doesn't predict future results.

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified September 11, 2026.