Gilead Sciences, Inc. (GILD) vs Vertex Pharmaceuticals Incorporated (VRTX)
A side-by-side comparison of Gilead Sciences, Inc. and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of July 29, 2026. Differences are shown without an overall score or investment verdict.
GILD
Gilead Sciences, Inc.
$133.27HealthcareDelayed quote: Jul 29, 2026, 3:35 PM EDT
VRTX
Vertex Pharmaceuticals Incorporated
$484.11HealthcareDelayed quote: Jul 29, 2026, 3:35 PM EDT
Total return — GILD vs VRTX
growth of $100 · dividends reinvested · last 30yGILD +33309.9%VRTX +3636.3%GILD compounded faster
Log scale — wide-divergence pair
GILD VRTX
GILD vs VRTX: by the numbers
- •GILD is the larger company ($165.46B vs $122.87B market cap).
- •GILD trades at the lower trailing earnings multiple (18.30 vs 29.09 P/E), one valuation lens rather than an overall verdict.
- •VRTX converts more revenue to profit (35.40% vs 30.99% net margin).
- •VRTX grew revenue faster over the past five years (13.82% vs 3.07% CAGR).
- •GILD pays a dividend (2.40% yield), while VRTX has no payments in the available dividend history.
Metrics side by side
Valuation
| Metric | GILD | VRTX |
|---|---|---|
| P/E ratio | 18.30 | 29.09 |
| Forward P/E | N/A | 25.51 |
| P/S ratio | 5.66 | 10.26 |
| P/B ratio | 7.16 | 6.49 |
| PEG ratio | 0.01 | 3.56 |
| EV / EBITDA | 12.95 | 24.48 |
| FCF yield | 6.07% | 2.95% |
Profitability
| Metric | GILD | VRTX |
|---|---|---|
| Gross margin | 79.35% | 86.28% |
| Operating margin | 38.26% | 38.97% |
| Net margin | 30.99% | 35.40% |
| ROE | 39.19% | 22.41% |
| ROIC | 21.53% | 18.12% |
Dividends
| Metric | GILD | VRTX |
|---|---|---|
| Dividend yield | 2.40% | N/A |
| Payout ratio | 47.08% | N/A |
Growth (annualized)
| Metric | GILD | VRTX |
|---|---|---|
| Revenue CAGR (5Y) | 3.07% | 13.82% |
| EPS CAGR (5Y) | 133.83% | 8.17% |
| FCF CAGR (5Y) | 3.30% | 4.01% |
| Total return CAGR (5Y) | 18.12% | 19.38% |
Frequently asked
- Which has the lower trailing P/E, GILD or VRTX?
- GILD has the lower trailing P/E: GILD trades at 18.30 and VRTX at 29.09. P/E is one valuation measure and does not by itself establish which business is cheaper.
- Which has grown faster, GILD or VRTX?
- Over the past five years, VRTX grew revenue faster — GILD at a 3.07% CAGR versus VRTX at 13.82%.
- Does GILD or VRTX pay a bigger dividend?
- GILD pays a dividend (2.40% yield), while VRTX has no payments in the available dividend history.
- Is GILD or VRTX more profitable?
- VRTX runs the higher net margin — GILD at 30.99% versus VRTX at 35.40%.
- How have GILD and VRTX total returns compared?
- Over the past 10 years, GILD delivered 8.95% and VRTX delivered 17.69% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Gilead Sciences P/E ratioVertex Pharmaceuticals P/E ratioGilead Sciences dividend yieldVertex Pharmaceuticals dividend yieldGilead Sciences ROEVertex Pharmaceuticals ROEGilead Sciences operating marginVertex Pharmaceuticals operating marginGilead Sciences revenue growthVertex Pharmaceuticals revenue growthGilead Sciences free cash flowVertex Pharmaceuticals free cash flow
Gilead Sciences & Vertex Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified July 29, 2026.