Gilead Sciences, Inc. (GILD) vs Vertex Pharmaceuticals Incorporated (VRTX)
GILD leads on 9 of 15 compared metrics.
A side-by-side comparison of Gilead Sciences, Inc. and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of June 14, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).
GILD
Gilead Sciences, Inc.
$125.59Healthcare
VRTX
Vertex Pharmaceuticals Incorporated
$444.93Healthcare
Total return — GILD vs VRTX
growth of $100 · last 30yGILD +14253.1%VRTX +2424.4%GILD compounded faster
Log scale — wide-divergence pair
GILD VRTX
GILD vs VRTX: by the numbers
- •GILD is the larger company ($155.93B vs $112.92B market cap).
- •GILD trades at the lower earnings multiple (17.11 vs 26.39 P/E).
- •VRTX converts more revenue to profit (35.40% vs 30.99% net margin).
- •VRTX grew revenue faster over the past five years (13.82% vs 3.07% CAGR).
- •GILD pays a dividend (1.91% yield) while VRTX does not currently pay one.
Which is better, GILD or VRTX?
Metric tally: GILD 9 · VRTX 6It depends on what you're optimizing for:
ValueGILD(lower P/E)
GrowthVRTX(faster 5Y revenue CAGR)
QualityGILD(higher ROIC)
Valuation
| Metric | GILD | VRTX |
|---|---|---|
| P/E ratio | 17.11● | 26.39 |
| Forward P/E | 13.00● | 20.58 |
| P/S ratio | 5.30● | 9.31 |
| P/B ratio | 6.70 | 5.89● |
| PEG ratio | 0.01● | 3.23 |
| EV / EBITDA | 12.91● | 20.72 |
| FCF yield | 6.49%● | 3.25% |
Profitability
| Metric | GILD | VRTX |
|---|---|---|
| Gross margin | 79.35% | 86.28%● |
| Operating margin | 38.26% | 38.97% |
| Net margin | 30.99% | 35.40%● |
| ROE | 39.19%● | 22.41% |
| ROIC | 21.53%● | 18.12% |
Dividends
| Metric | GILD | VRTX |
|---|---|---|
| Dividend yield | 1.91% | — |
| Payout ratio | 35.09% | — |
Growth (annualized)
| Metric | GILD | VRTX |
|---|---|---|
| Revenue CAGR (5Y) | 3.07% | 13.82%● |
| EPS CAGR (5Y) | 133.83%● | 8.17% |
| FCF CAGR (5Y) | 3.30% | 4.01%● |
| Total return CAGR (5Y) | 17.06% | 18.17%● |
Frequently asked
- Which is better, GILD or VRTX?
- It depends on your goal. value: GILD (lower P/E); growth: VRTX (faster 5Y revenue CAGR); quality: GILD (higher ROIC). Across all compared metrics, GILD leads 9 to 6.
- Is GILD or VRTX cheaper?
- On trailing earnings, GILD is cheaper: GILD trades at a 17.11 P/E and VRTX at 26.39.
- Which has grown faster, GILD or VRTX?
- Over the past five years, VRTX grew revenue faster — GILD at a 3.07% CAGR versus VRTX at 13.82%.
- Does GILD or VRTX pay a bigger dividend?
- GILD pays a dividend (1.91% yield) while VRTX does not currently pay one.
- Is GILD or VRTX more profitable?
- VRTX runs the higher net margin — GILD at 30.99% versus VRTX at 35.40%.
- Which has been the better investment, GILD or VRTX?
- Over the past 10-year, VRTX delivered the higher annualized total return — GILD at 7.79% versus VRTX at 17.13%. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Gilead Sciences P/E ratioVertex Pharmaceuticals P/E ratioGilead Sciences dividend yieldVertex Pharmaceuticals dividend yieldGilead Sciences ROEVertex Pharmaceuticals ROEGilead Sciences operating marginVertex Pharmaceuticals operating marginGilead Sciences revenue growthVertex Pharmaceuticals revenue growthGilead Sciences free cash flowVertex Pharmaceuticals free cash flow
Gilead Sciences & Vertex Pharmaceuticals appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified June 14, 2026.