Charles River Laboratories International, Inc. (CRL) vs Summit Therapeutics Inc. (SMMT)
A side-by-side comparison of Charles River Laboratories International, Inc. and Summit Therapeutics Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
CRL
Charles River Laboratories International, Inc.
$303.94HealthcareDelayed quote: Oct 6, 2026, 3:35 PM EDT
SMMT
Summit Therapeutics Inc.
$17.11HealthcareDelayed quote: Oct 6, 2026, 3:35 PM EDT
Total return — CRL vs SMMT
growth of $100 · dividends reinvested · last 10yCRL +274.1% (+14.1%/yr)SMMT +29.2% (+2.6%/yr)CRL compounded faster over this window
CRL SMMT
CRL vs SMMT: by the numbers
- •CRL is the larger company ($14.64B vs $13.65B market cap).
- •Both run net losses; SMMT's is the smaller (0.00% vs -5.96% net margin).
Metrics side by side
Valuation
| Metric | CRL | SMMT |
|---|---|---|
| Forward P/E | 26.78 | N/A |
| P/S ratio | 3.66 | N/A |
| P/B ratio | 5.16 | 21.66 |
| EV / EBITDA | 22.07 | N/A |
| FCF yield | 2.53% | N/A |
Profitability
| Metric | CRL | SMMT |
|---|---|---|
| Gross margin | 32.24% | 0.00% |
| Operating margin | 12.35% | 0.00% |
| Net margin | -5.96% | 0.00% |
| ROE | -8.40% | -135.89% |
| ROIC | 7.72% | -134.14% |
Growth (annualized)
| Metric | CRL | SMMT |
|---|---|---|
| Revenue CAGR (5Y) | 4.08% | N/A |
| FCF CAGR (5Y) | 6.43% | N/A |
| Total return CAGR (5Y) | -4.99% | 28.09% |
Frequently asked
- How have CRL and SMMT total returns compared?
- Over the past 10 years, CRL delivered 14.12% and SMMT delivered 1.87% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Charles River Laboratories International ROESummit Therapeutics ROECharles River Laboratories International operating marginSummit Therapeutics operating marginCharles River Laboratories International revenue growthSummit Therapeutics revenue growthCharles River Laboratories International free cash flowSummit Therapeutics free cash flow
Charles River Laboratories International & Summit Therapeutics appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.