Charles River Laboratories International, Inc. (CRL) vs Penumbra, Inc. (PEN)
A side-by-side comparison of Charles River Laboratories International, Inc. and Penumbra, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of August 29, 2026. Differences are shown without an overall score or investment verdict.
CRL
Charles River Laboratories International, Inc.
$291.50HealthcareAt close: Aug 28, 2026, 4:00 PM ET
PEN
Penumbra, Inc.
$321.68HealthcareDelayed quote: Aug 28, 2026, 4:00 PM EDT
Total return — CRL vs PEN
growth of $100 · dividends reinvested · last 10yCRL +255.8% (+13.5%/yr)PEN +356.1% (+16.4%/yr)PEN compounded faster over this window
CRL PEN
CRL vs PEN: by the numbers
- •CRL is the larger company ($14.04B vs $12.67B market cap).
- •PEN is profitable (10.67% net margin) while CRL runs a net loss (-5.96%).
- •PEN grew revenue faster over the past five years (17.52% vs 4.08% CAGR).
Metrics side by side
Valuation
| Metric | CRL | PEN |
|---|---|---|
| P/E ratio | N/A | 79.08 |
| Forward P/E | 25.75 | 68.36 |
| P/S ratio | 3.53 | 8.46 |
| P/B ratio | 4.98 | 8.32 |
| EV / EBITDA | 21.43 | 62.32 |
| FCF yield | 2.62% | 1.70% |
Profitability
| Metric | CRL | PEN |
|---|---|---|
| Gross margin | 32.24% | 67.84% |
| Operating margin | 12.35% | 12.45% |
| Net margin | -5.96% | 10.67% |
| ROE | -8.40% | 10.49% |
| ROIC | 7.72% | 8.48% |
Growth (annualized)
| Metric | CRL | PEN |
|---|---|---|
| Revenue CAGR (5Y) | 4.08% | 17.52% |
| EPS CAGR (5Y) | -47.86% | 21.94% |
| FCF CAGR (5Y) | 6.43% | 83.74% |
| Total return CAGR (5Y) | -7.77% | 3.44% |
Frequently asked
- Which has grown faster, CRL or PEN?
- Over the past five years, PEN grew revenue faster — CRL at a 4.08% CAGR versus PEN at 17.52%.
- Is CRL or PEN more profitable?
- PEN runs the higher net margin — CRL at -5.96% versus PEN at 10.67%.
- How have CRL and PEN total returns compared?
- Over the past 10 years, CRL delivered 13.36% and PEN delivered 16.18% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Penumbra P/E ratioCharles River Laboratories International ROEPenumbra ROECharles River Laboratories International operating marginPenumbra operating marginCharles River Laboratories International revenue growthPenumbra revenue growthCharles River Laboratories International free cash flowPenumbra free cash flow
Charles River Laboratories International & Penumbra appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified August 29, 2026.