Which has grown faster, CRL or NBIX?

Over the past five years, NBIX grew revenue faster — CRL at a 4.08% CAGR versus NBIX at 26.74%.

Is CRL or NBIX more profitable?

NBIX runs the higher net margin — CRL at -5.96% versus NBIX at 20.91%.

How have CRL and NBIX total returns compared?

Over the past 10 years, CRL delivered 14.12% and NBIX delivered 10.90% annualized total return. Past performance doesn't predict future results.

Charles River Laboratories International, Inc. (CRL) vs Neurocrine Biosciences, Inc. (NBIX)

A side-by-side comparison of Charles River Laboratories International, Inc. and Neurocrine Biosciences, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

CRL

Charles River Laboratories International, Inc.

$14.69B

$304.96HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

NBIX

Neurocrine Biosciences, Inc.

$14.63B

$145.51HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — CRL vs NBIX

growth of $100 · dividends reinvested · last 10y

CRL +284.1% (+14.4%/yr)NBIX +186.9% (+11.1%/yr)CRL compounded faster over this window

CRL NBIX

CRL vs NBIX: by the numbers

•CRL is the larger company ($14.69B vs $14.63B market cap).
•NBIX is profitable (20.91% net margin) while CRL runs a net loss (-5.96%).
•NBIX grew revenue faster over the past five years (26.74% vs 4.08% CAGR).

Metrics side by side

Valuation

Metric	CRL	NBIX
P/E ratio	N/A	21.34
Forward P/E	26.87	20.60
PEG ratio	N/A	9.12
P/S ratio	3.67	4.34
P/B ratio	5.17	3.96
EV / EBITDA	22.14	17.58
FCF yield	2.52%	5.92%

Profitability

Metric	CRL	NBIX
Gross margin	32.24%	97.97%
Operating margin	12.35%	23.38%
Net margin	-5.96%	20.91%
ROE	-8.40%	19.10%
ROIC	7.72%	13.20%

Growth (annualized)

Metric	CRL	NBIX
Revenue CAGR (5Y)	4.08%	26.74%
EPS CAGR (5Y)	N/A	1.94%
FCF CAGR (5Y)	6.43%	28.69%
Total return CAGR (5Y)	-4.99%	7.56%

Frequently asked

Which has grown faster, CRL or NBIX?: Over the past five years, NBIX grew revenue faster — CRL at a 4.08% CAGR versus NBIX at 26.74%.
Is CRL or NBIX more profitable?: NBIX runs the higher net margin — CRL at -5.96% versus NBIX at 20.91%.
How have CRL and NBIX total returns compared?: Over the past 10 years, CRL delivered 14.12% and NBIX delivered 10.90% annualized total return. Past performance doesn't predict future results.

Go deeper

Full CRL analysis Full NBIX analysis Interactive comparison tool

Dig into the metrics

Neurocrine Biosciences P/E ratio Charles River Laboratories International ROE Neurocrine Biosciences ROE Charles River Laboratories International operating margin Neurocrine Biosciences operating margin Charles River Laboratories International revenue growth Neurocrine Biosciences revenue growth Charles River Laboratories International free cash flow Neurocrine Biosciences free cash flow

Charles River Laboratories International & Neurocrine Biosciences appear in these rankings

Fastest Revenue Growth Stocks Highest FCF Yield Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.