Charles River Laboratories International, Inc. (CRL) vs Exelixis, Inc. (EXEL)
A side-by-side comparison of Charles River Laboratories International, Inc. and Exelixis, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.
CRL
Charles River Laboratories International, Inc.
$310.77HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT
EXEL
Exelixis, Inc.
$58.85HealthcareDelayed quote: Oct 5, 2026, 4:00 PM EDT
Total return — CRL vs EXEL
growth of $100 · dividends reinvested · last 10yCRL +274.1% (+14.1%/yr)EXEL +346.5% (+16.1%/yr)EXEL compounded faster over this window
CRL EXEL
CRL vs EXEL: by the numbers
- •CRL is the larger company ($14.97B vs $14.79B market cap).
- •EXEL is profitable (35.33% net margin) while CRL runs a net loss (-5.96%).
- •EXEL grew revenue faster over the past five years (16.06% vs 4.08% CAGR).
Metrics side by side
Valuation
| Metric | CRL | EXEL |
|---|---|---|
| P/E ratio | N/A | 18.45 |
| Forward P/E | 27.39 | 16.75 |
| PEG ratio | N/A | 0.36 |
| P/S ratio | 3.74 | 6.07 |
| P/B ratio | 5.27 | 8.02 |
| EV / EBITDA | 22.49 | 14.68 |
| FCF yield | 2.48% | 7.83% |
Profitability
| Metric | CRL | EXEL |
|---|---|---|
| Gross margin | 32.24% | 96.48% |
| Operating margin | 12.35% | 39.88% |
| Net margin | -5.96% | 35.33% |
| ROE | -8.40% | 46.68% |
| ROIC | 7.72% | 37.87% |
Growth (annualized)
| Metric | CRL | EXEL |
|---|---|---|
| Revenue CAGR (5Y) | 4.08% | 16.06% |
| EPS CAGR (5Y) | N/A | 51.51% |
| FCF CAGR (5Y) | 6.43% | 39.63% |
| Total return CAGR (5Y) | -4.99% | 23.00% |
Frequently asked
- Which has grown faster, CRL or EXEL?
- Over the past five years, EXEL grew revenue faster — CRL at a 4.08% CAGR versus EXEL at 16.06%.
- Is CRL or EXEL more profitable?
- EXEL runs the higher net margin — CRL at -5.96% versus EXEL at 35.33%.
- How have CRL and EXEL total returns compared?
- Over the past 10 years, CRL delivered 14.12% and EXEL delivered 16.20% annualized total return. Past performance doesn't predict future results.
Go deeper
Dig into the metrics
Exelixis P/E ratioCharles River Laboratories International ROEExelixis ROECharles River Laboratories International operating marginExelixis operating marginCharles River Laboratories International revenue growthExelixis revenue growthCharles River Laboratories International free cash flowExelixis free cash flow
Charles River Laboratories International & Exelixis appear in these rankings
Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.