Which has grown faster, COSM or KPTI?

Over the past five years, KPTI grew revenue faster — COSM at a 5.24% CAGR versus KPTI at 7.47%.

How have COSM and KPTI total returns compared?

Over the past 10 years, COSM delivered -45.52% and KPTI delivered -41.85% annualized total return. Past performance doesn't predict future results.

Cosmos Health Inc. (COSM) vs Karyopharm Therapeutics Inc. (KPTI)

A side-by-side comparison of Cosmos Health Inc. and Karyopharm Therapeutics Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

COSM

Cosmos Health Inc.

$18M

$0.32HealthcareDelayed quote: Oct 6, 2026, 11:59 AM EDT

KPTI

Karyopharm Therapeutics Inc.

$15M

$0.67HealthcareDelayed quote: Oct 6, 2026, 11:55 AM EDT

Total return — COSM vs KPTI

growth of $100 · dividends reinvested · last 10y

COSM -99.8% (-45.5%/yr)KPTI -99.5% (-41.6%/yr)KPTI compounded faster over this window

COSM KPTI

COSM vs KPTI: by the numbers

•COSM is the larger company ($18M vs $15M market cap).
•Both run net losses; COSM's is the smaller (-33.08% vs -153.28% net margin).
•KPTI grew revenue faster over the past five years (7.47% vs 5.24% CAGR).

Metrics side by side

Valuation

Metric	COSM	KPTI
P/S ratio	0.24	0.10
P/B ratio	0.85	N/A

Profitability

Metric	COSM	KPTI
Gross margin	10.27%	95.88%
Operating margin	-24.65%	-56.17%
Net margin	-33.08%	-153.28%
ROE	-117.98%	N/A
ROIC	-46.69%	N/A

Growth (annualized)

Metric	COSM	KPTI
Revenue CAGR (5Y)	5.24%	7.47%
Total return CAGR (5Y)	-68.41%	-62.18%

Frequently asked

Which has grown faster, COSM or KPTI?: Over the past five years, KPTI grew revenue faster — COSM at a 5.24% CAGR versus KPTI at 7.47%.
How have COSM and KPTI total returns compared?: Over the past 10 years, COSM delivered -45.52% and KPTI delivered -41.85% annualized total return. Past performance doesn't predict future results.

Go deeper

Full COSM analysis Full KPTI analysis Interactive comparison tool

Dig into the metrics

Cosmos Health ROE Karyopharm Therapeutics ROE Cosmos Health operating margin Karyopharm Therapeutics operating margin Cosmos Health revenue growth Karyopharm Therapeutics revenue growth Cosmos Health free cash flow Karyopharm Therapeutics free cash flow

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.