Is AXSM or KRYS more profitable?

KRYS runs the higher net margin — AXSM at -24.68% versus KRYS at 54.82%.

How have AXSM and KRYS total returns compared?

Over the past 5 years, AXSM delivered 41.40% and KRYS delivered 44.28% annualized total return. Past performance doesn't predict future results.

Axsome Therapeutics, Inc. (AXSM) vs Krystal Biotech, Inc. (KRYS)

A side-by-side comparison of Axsome Therapeutics, Inc. and Krystal Biotech, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

AXSM

Axsome Therapeutics, Inc.

$9.01B

$175.18HealthcareDelayed quote: Oct 6, 2026, 2:50 PM EDT

KRYS

Krystal Biotech, Inc.

$9.62B

$326.38HealthcareDelayed quote: Oct 6, 2026, 2:50 PM EDT

Total return — AXSM vs KRYS

growth of $100 · dividends reinvested · last 9y

AXSM +3372.2% (+48.3%/yr)KRYS +3047.1% (+46.7%/yr)AXSM compounded faster over this window

AXSM KRYS

AXSM vs KRYS: by the numbers

•KRYS is the larger company ($9.62B vs $9.01B market cap).
•KRYS is profitable (54.82% net margin) while AXSM runs a net loss (-24.68%).

Metrics side by side

Valuation

Metric	AXSM	KRYS
P/E ratio	N/A	40.90
Forward P/E	N/A	42.90
P/S ratio	11.61	21.84
P/B ratio	108.21	7.08
EV / EBITDA	N/A	45.03
FCF yield	N/A	2.68%

Profitability

Metric	AXSM	KRYS
Gross margin	93.24%	93.34%
Operating margin	-24.28%	44.93%
Net margin	-24.68%	54.82%
ROE	-230.05%	17.77%
ROIC	-50.82%	14.41%

Growth (annualized)

Metric	AXSM	KRYS
Total return CAGR (5Y)	41.40%	44.28%

Frequently asked

Is AXSM or KRYS more profitable?: KRYS runs the higher net margin — AXSM at -24.68% versus KRYS at 54.82%.
How have AXSM and KRYS total returns compared?: Over the past 5 years, AXSM delivered 41.40% and KRYS delivered 44.28% annualized total return. Past performance doesn't predict future results.

Go deeper

Full AXSM analysis Full KRYS analysis Interactive comparison tool

Dig into the metrics

Krystal Biotech P/E ratio Axsome Therapeutics ROE Krystal Biotech ROE Axsome Therapeutics operating margin Krystal Biotech operating margin Axsome Therapeutics revenue growth Krystal Biotech revenue growth Axsome Therapeutics free cash flow Krystal Biotech free cash flow

Axsome Therapeutics & Krystal Biotech appear in these rankings

Highest Operating Margin Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.