Which has grown faster, ASTH or ZYME?

Over the past five years, ASTH grew revenue faster — ASTH at a 53.77% CAGR versus ZYME at 12.35%.

Is ASTH or ZYME more profitable?

ASTH runs the higher net margin — ASTH at 1.05% versus ZYME at -404.00%.

How have ASTH and ZYME total returns compared?

Over the past 5 years, ASTH delivered -16.52% and ZYME delivered -1.37% annualized total return. Past performance doesn't predict future results.

Astrana Health, Inc. (ASTH) vs Zymeworks Inc. (ZYME)

A side-by-side comparison of Astrana Health, Inc. and Zymeworks Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

ASTH

Astrana Health, Inc.

$1.83B

$37.00HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

ZYME

Zymeworks Inc.

$1.89B

$25.65HealthcareDelayed quote: Oct 6, 2026, 4:00 PM EDT

Total return — ASTH vs ZYME

growth of $100 · dividends reinvested · last 9y

ASTH +308.5% (+16.9%/yr)ZYME +101.6% (+8.1%/yr)ASTH compounded faster over this window

ASTH ZYME

ASTH vs ZYME: by the numbers

•ZYME is the larger company ($1.89B vs $1.83B market cap).
•ASTH is profitable (1.05% net margin) while ZYME runs a net loss (-404.00%).
•ASTH grew revenue faster over the past five years (53.77% vs 12.35% CAGR).

Metrics side by side

Valuation

Metric	ASTH	ZYME
P/E ratio	45.26	N/A
Forward P/E	26.47	24.73
P/S ratio	0.48	50.83
P/B ratio	2.21	23.48
EV / EBITDA	13.48	N/A
FCF yield	8.64%	N/A

Profitability

Metric	ASTH	ZYME
Gross margin	9.22%	100.00%
Operating margin	2.61%	-87.33%
Net margin	1.05%	-404.00%
ROE	4.88%	-186.63%
ROIC	4.13%	-44.06%

Growth (annualized)

Metric	ASTH	ZYME
Revenue CAGR (5Y)	53.77%	12.35%
EPS CAGR (5Y)	-15.06%	N/A
FCF CAGR (5Y)	18.35%	N/A
Total return CAGR (5Y)	-16.52%	-1.37%

Frequently asked

Which has grown faster, ASTH or ZYME?: Over the past five years, ASTH grew revenue faster — ASTH at a 53.77% CAGR versus ZYME at 12.35%.
Is ASTH or ZYME more profitable?: ASTH runs the higher net margin — ASTH at 1.05% versus ZYME at -404.00%.
How have ASTH and ZYME total returns compared?: Over the past 5 years, ASTH delivered -16.52% and ZYME delivered -1.37% annualized total return. Past performance doesn't predict future results.

Go deeper

Full ASTH analysis Full ZYME analysis Interactive comparison tool

Dig into the metrics

Astrana Health P/E ratio Astrana Health ROE Zymeworks ROE Astrana Health operating margin Zymeworks operating margin Astrana Health revenue growth Zymeworks revenue growth Astrana Health free cash flow Zymeworks free cash flow

Astrana Health & Zymeworks appear in these rankings

Fastest Revenue Growth Stocks Highest FCF Yield Stocks Highest 10-Year Total Return Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.