Which has grown faster, AMPH or OPK?

Over the past five years, AMPH grew revenue faster — AMPH at a 13.71% CAGR versus OPK at -21.00%.

Is AMPH or OPK more profitable?

AMPH runs the higher net margin — AMPH at 10.76% versus OPK at -12.40%.

How have AMPH and OPK total returns compared?

Over the past 10 years, AMPH delivered 2.47% and OPK delivered -17.50% annualized total return. Past performance doesn't predict future results.

Amphastar Pharmaceuticals, Inc. (AMPH) vs OPKO Health, Inc. (OPK)

A side-by-side comparison of Amphastar Pharmaceuticals, Inc. and OPKO Health, Inc. across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of October 6, 2026. Differences are shown without an overall score or investment verdict.

AMPH

Amphastar Pharmaceuticals, Inc.

$1.13B

$25.62HealthcareDelayed quote: Oct 6, 2026, 12:55 PM EDT

OPK

OPKO Health, Inc.

$1.12B

$1.50HealthcareDelayed quote: Oct 6, 2026, 12:55 PM EDT

Total return — AMPH vs OPK

growth of $100 · dividends reinvested · last 10y

AMPH +32.8% (+2.9%/yr)OPK -85.2% (-17.4%/yr)AMPH compounded faster over this window

Log scale — wide-divergence pair

AMPH OPK

AMPH vs OPK: by the numbers

•AMPH is the larger company ($1.13B vs $1.12B market cap).
•AMPH is profitable (10.76% net margin) while OPK runs a net loss (-12.40%).
•AMPH grew revenue faster over the past five years (13.71% vs -21.00% CAGR).

Metrics side by side

Valuation

Metric	AMPH	OPK
P/E ratio	15.16	N/A
Forward P/E	8.62	N/A
PEG ratio	0.11	N/A
P/S ratio	1.55	1.90
P/B ratio	1.47	0.95
EV / EBITDA	8.88	N/A
FCF yield	13.54%	N/A

Profitability

Metric	AMPH	OPK
Gross margin	47.68%	21.10%
Operating margin	15.66%	-36.08%
Net margin	10.76%	-12.40%
ROE	10.23%	-6.16%
ROIC	5.93%	-8.86%

Growth (annualized)

Metric	AMPH	OPK
Revenue CAGR (5Y)	13.71%	-21.00%
EPS CAGR (5Y)	134.23%	N/A
FCF CAGR (5Y)	23.90%	N/A
Total return CAGR (5Y)	6.13%	-15.39%

Frequently asked

Which has grown faster, AMPH or OPK?: Over the past five years, AMPH grew revenue faster — AMPH at a 13.71% CAGR versus OPK at -21.00%.
Is AMPH or OPK more profitable?: AMPH runs the higher net margin — AMPH at 10.76% versus OPK at -12.40%.
How have AMPH and OPK total returns compared?: Over the past 10 years, AMPH delivered 2.47% and OPK delivered -17.50% annualized total return. Past performance doesn't predict future results.

Go deeper

Full AMPH analysis Full OPK analysis Interactive comparison tool

Dig into the metrics

Amphastar Pharmaceuticals P/E ratio Amphastar Pharmaceuticals ROE OPKO Health ROE Amphastar Pharmaceuticals operating margin OPKO Health operating margin Amphastar Pharmaceuticals revenue growth OPKO Health revenue growth Amphastar Pharmaceuticals free cash flow OPKO Health free cash flow

Amphastar Pharmaceuticals & OPKO Health appear in these rankings

Highest FCF Yield Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified October 6, 2026.