Is AMGN or VRTX cheaper?

On trailing earnings, AMGN is cheaper: AMGN trades at a 25.61 P/E and VRTX at 29.56.

Which has grown faster, AMGN or VRTX?

Over the past five years, VRTX grew revenue faster — AMGN at a 8.15% CAGR versus VRTX at 13.82%.

Does AMGN or VRTX pay a bigger dividend?

AMGN pays a dividend (2.74% yield) while VRTX does not currently pay one.

Is AMGN or VRTX more profitable?

VRTX runs the higher net margin — AMGN at 20.95% versus VRTX at 35.40%.

Which has been the better investment, AMGN or VRTX?

Over the past 10-year, VRTX delivered the higher annualized total return — AMGN at 11.89% versus VRTX at 18.81%. Past performance doesn't predict future results.

Amgen Inc. (AMGN) vs Vertex Pharmaceuticals Incorporated (VRTX)

VRTX leads on 9 of 16 compared metrics, though AMGN is the cheaper stock.

A side-by-side comparison of Amgen Inc. and Vertex Pharmaceuticals Incorporated across valuation, profitability, dividends, and growth — built entirely from reported fundamentals, as of July 9, 2026. The ● marks the stronger figure on each row (cheaper multiple, higher margin/return).

Vertex Pharmaceuticals Incorporated

$126.01B

$496.50Healthcare

Total return — AMGN vs VRTX

growth of $100 · last 30y

AMGN +2677.3%VRTX +3168.4%VRTX compounded faster

AMGN VRTX

AMGN vs VRTX: by the numbers

•AMGN is the larger company ($196.25B vs $126.01B market cap).
•AMGN trades at the lower earnings multiple (25.61 vs 29.56 P/E).
•VRTX converts more revenue to profit (35.40% vs 20.95% net margin).
•VRTX grew revenue faster over the past five years (13.82% vs 8.15% CAGR).
•AMGN pays a dividend (2.74% yield) while VRTX does not currently pay one.

Which is better, AMGN or VRTX?

Metric tally: AMGN 7 · VRTX 9

It depends on what you're optimizing for:

ValueAMGN(lower P/E)

GrowthVRTX(faster 5Y revenue CAGR)

QualityVRTX(higher ROIC)

Metrics side by side

Valuation

Metric	AMGN	VRTX
P/E ratio	25.61●	29.56
Forward P/E	16.45●	25.80
P/S ratio	5.38●	10.42
P/B ratio	21.78	6.60●
PEG ratio	0.26●	3.62
EV / EBITDA	14.72●	24.90
FCF yield	4.29%●	2.90%

Profitability

Metric	AMGN	VRTX
Gross margin	71.46%	86.28%●
Operating margin	31.63%	38.97%●
Net margin	20.95%	35.40%●
ROE	84.87%●	22.41%
ROIC	13.16%	18.12%●

Dividends

Metric	AMGN	VRTX
Dividend yield	2.74%	—
Payout ratio	70.34%	—

Growth (annualized)

Metric	AMGN	VRTX
Revenue CAGR (5Y)	8.15%	13.82%●
EPS CAGR (5Y)	2.94%	8.17%●
FCF CAGR (5Y)	-2.66%	4.01%●
Total return CAGR (5Y)	12.02%	20.31%●

Frequently asked

Which is better, AMGN or VRTX?: It depends on your goal. value: AMGN (lower P/E); growth: VRTX (faster 5Y revenue CAGR); quality: VRTX (higher ROIC). Across all compared metrics, VRTX leads 9 to 7.
Is AMGN or VRTX cheaper?: On trailing earnings, AMGN is cheaper: AMGN trades at a 25.61 P/E and VRTX at 29.56.
Which has grown faster, AMGN or VRTX?: Over the past five years, VRTX grew revenue faster — AMGN at a 8.15% CAGR versus VRTX at 13.82%.
Does AMGN or VRTX pay a bigger dividend?: AMGN pays a dividend (2.74% yield) while VRTX does not currently pay one.
Is AMGN or VRTX more profitable?: VRTX runs the higher net margin — AMGN at 20.95% versus VRTX at 35.40%.
Which has been the better investment, AMGN or VRTX?: Over the past 10-year, VRTX delivered the higher annualized total return — AMGN at 11.89% versus VRTX at 18.81%. Past performance doesn't predict future results.

Go deeper

Full AMGN analysis Full VRTX analysis Interactive comparison tool

Dig into the metrics

Amgen P/E ratio Vertex Pharmaceuticals P/E ratio Amgen dividend yield Vertex Pharmaceuticals dividend yield Amgen ROE Vertex Pharmaceuticals ROE Amgen operating margin Vertex Pharmaceuticals operating margin Amgen revenue growth Vertex Pharmaceuticals revenue growth Amgen free cash flow Vertex Pharmaceuticals free cash flow

Amgen & Vertex Pharmaceuticals appear in these rankings

Highest Dividend Yield Stocks Highest ROE Stocks Highest ROIC Stocks Highest Operating Margin Stocks

Figures are sourced from reported fundamentals and the latest end-of-day price. This comparison is informational only and is not investment advice. Past performance does not predict future results. See our methodology. Compiled by TGMCharts Research · data verified July 9, 2026.